(S)-Flurbiprofen | Esflurbiprofen | COX Inhibitor | AmBeed-信号通路专用抑制剂

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(S)-Flurbiprofen/(S)-氟比洛芬 {[allProObj[0].p_purity_real_show]}

货号：A732143 同义名： Esflurbiprofen

(S)-Flurbiprofen 是一种环氧合酶（COX）抑制剂，指示用于骨关节炎疼痛和炎症的研究。

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(S)-Flurbiprofen/(S)-氟比洛芬化学结构
CAS号：51543-39-6

(S)-Flurbiprofen/(S)-氟比洛芬 3D分子结构
CAS号：51543-39-6

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(S)-Flurbiprofen/(S)-氟比洛芬纯度/质量文件产品仅供科研

货号：A732143 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]; • Cell, 2025. Ambeed. [ A122167 ]; • Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]; • Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]; • Nat. Nanotechnol., 2025. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]; 更多 >

环氧化酶亚型比较

产品名称	COX ↓ ↑	COX-1 ↓ ↑	COX-2 ↓ ↑	纯度
Piroxicam	✔			98%
Salicylic acid	✔			98%
Phenacetin	✔			98%
Etodolac	✔			99%
Flunixin meglumine	✔			98%
Ibuprofen L-lysine	✔			98%
Nabumetone	✔			98%
Acemetacin	✔			98%
Diflunisal	✔			98%
Pranoprofen	✔			98%
Ampiroxicam	✔			98%
Meloxicam	✔			98%
Sulindac	✔			98%
Ketoprofen		✔		98%
Mefenamic Acid		✔		95%
Bromfenac sodium		✔		98%
Oxaprozin		✔		99%
Aspirin		✔		99%
Nepafenac		✔		98%
Zaltoprofen		✔		99%
Salicin		✔		98%
Suprofen		✔		99%+
Xanthohumol		✔		99%
Parecoxib			✔	98%
Tolfenamic Acid			+++ COX-2, IC50: 0.2 μM	98%
Etoricoxib			✔	99%
Niflumic Acid			✔	98%
Valdecoxib			++++ COX-2, IC50: 5 nM	99+%
Ibuprofen		+ COX-1, IC50: 13 μM	+ COX-2, IC50: 370 μM	98%
Indomethacin		++ COX1, IC50: 0.28 μM	+ COX-2, IC50: 14 μM	97%
Lornoxicam		++++ COX-1, IC50: 5 nM	++++ COX-2, IC50: 8 nM	98%
Meclofenamic acid sodium		++++ COX-1, IC50: 40 nM	+++ COX-2, IC50: 50 nM	99%
Asaraldehyde			✔	98%
Naproxen		+ COX-1, IC50: 8.7 μM	+ COX-2, IC50: 5.2 μM	98%
Diclofenac Sodium Salt		+++ COX-1, IC50: 60 nM	+++ COX-2, IC50: 200 nM	98%
NS-398			++ COX-2, IC50: 3.8 μM	95%
Amfenac Sodium Hydrate		++ COX-1, IC50: 250 nM	+++ COX-2, IC50: 150 nM	98%+
Nimesulide			+ COX-2, IC50: 26 μM	98%
Lumiracoxib		++ COX-1, Ki: 3 μM	+++ COX-2, Ki: 60 nM	98%
Rutaecarpine			✔	95%
Celecoxib			++++ COX-2, IC50: 40 nM	98%
Carprofen			++++ canine COX2, IC50: 30 nM	98%
Ketorolac		++ COX-1 (human), IC50: 1.23 μM	++ COX-2 (human), IC50: 3.50 μM	98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

(S)-Flurbiprofen/(S)-氟比洛芬生物活性

描述	(S)-Flurbiprofen, the active enantiomer of Flurbiprofen, possesses IC50 values of 0.48 μM and 0.47 μM for COX-1 and COX-2, respectively^[1].
体外研究	(S)-Flurbiprofen, at a concentration of 10–7 M, completely suppresses basal and stimulated PGE2 release in rat skin[2].

(S)-Flurbiprofen/(S)-氟比洛芬细胞实验

Cell Line CHO cells H4 neuroglioma cells	Concentration	Treated Time	Description	References
CHO cells	250 µM	24 hours	To evaluate the effect of meclofenamic acid on Aβ42 secretion, results showed that meclofenamic acid significantly reduced Aβ42 levels and increased levels of shorter Aβ derivatives	J Clin Invest. 2003 Aug;112(3):440-9.
H4 neuroglioma cells	100 µM	6 hours	To evaluate the effect of meclofenamic acid on Aβ42 secretion, results showed that meclofenamic acid significantly reduced Aβ42 levels	J Clin Invest. 2003 Aug;112(3):440-9.

(S)-Flurbiprofen/(S)-氟比洛芬参考文献

[1]A Carabaza, et al. Stereoselective Inhibition of Inducible Cyclooxygenase by Chiral Nonsteroidal Antiinflammatory Drugs. J Clin Pharmacol. 1996 Jun;36(6):505-12.

(S)-Flurbiprofen/(S)-氟比洛芬实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

4.09mL

0.82mL

0.41mL

20.47mL

4.09mL

2.05mL

40.94mL

8.19mL

4.09mL

(S)-Flurbiprofen/(S)-氟比洛芬技术信息

CAS号	51543-39-6
分子式	C₁₅H₁₃FO₂
分子量	244.26
SMILES Code	C[C@@H](C1=CC=C(C2=CC=CC=C2)C(F)=C1)C(O)=O
MDL No.	MFCD00866152

别名	Esflurbiprofen
运输	蓝冰
InChI Key	SYTBZMRGLBWNTM-JTQLQIEISA-N
Pubchem ID	72099

存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Keep in dark place, sealed in dry, 2-8°C

溶解方案

细胞实验：

DMSO: 105 mg/mL(429.87 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验：请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用；以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

方案二

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(S)-Flurbiprofen/(S)-氟比洛芬纯度/质量文件产品仅供科研

(S)-Flurbiprofen/(S)-氟比洛芬质控信息

(S)-Flurbiprofen/(S)-氟比洛芬生物活性

(S)-Flurbiprofen/(S)-氟比洛芬细胞实验

(S)-Flurbiprofen/(S)-氟比洛芬参考文献

(S)-Flurbiprofen/(S)-氟比洛芬实验方案

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