Scopine/东莨菪醇
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货号：A578511
同义名：
6,7-Epoxytropine
Scopine 是一种天然来源的 α1-肾上腺素受体激动剂，是 Anisodine 的代谢产物，可用于急性循环衰竭的研究。
Scopine/东莨菪醇 化学结构
Scopine/东莨菪醇 3D分子结构
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Scopine/东莨菪醇 纯度/质量文件 产品仅供科研
货号：A578511
标准纯度：
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产品说明书
全球学术期刊中引用的产品
• Nature , 2025, 645, 793-800. Ambeed. A201204 ,
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• Cell , 2025. Ambeed. A122167
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• Science , 2025, 387(6729): eadp5637. Ambeed. • Sig. Transduct. Target. Ther. , 2025, 10, 257. Ambeed. A104916
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• Nat. Nanotechnol. , 2025. Ambeed. A1216705 ,
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Scopine/东莨菪醇 质控信息
Ivabradine HCl
✔
98%
Maprotiline HCl
✔
98%
Cisatracurium besylate
✔
96%
Yohimbine HCI
✔
99+%
BMY 7378
++
α1D-adrenoceptor, pKi: 5.1
α2C-adrenoceptor, pKi: 6.54
+
β1-adrenoceptor, pIC50: 5.1
97%
Asenapine maleate
++++
α2B-adrenergic receptor, pKi: 8.9
α2A-adrenergic receptor, pKi: 8.9
97%
Piribedil
++
adrenoceptor α2C, pKi: 7.2
adrenoceptor α2A, pKi: 7.1
98%
Prazosin HCl
✔
95%
Silodosin
✔
98%
Phenoxybenzamine HCl
✔
98%
Labetalol HCl
✔
98+%
Naftopidil
+++
α1D-adrenergic receptor, Ki: 20 nM
α1A-adrenergic receptor, Ki: 3.7 nM
98%
Naftopidil 2HCl
+
α1-adrenergic receptor, IC50: 0.2 μM
99%
Alfuzosin HCl
✔
98%
Terazosin HCl
✔
99%
Atipamezole
✔
95%
Phentolamine methanesulfonate salt
✔
99%
Carvedilol
✔
99%
Doxazosin mesylate
✔
99%
Tolazoline HCl
✔
98%
Esmolol HCl
✔
95%
Propranolol HCl
++
β-adrenergic receptor, IC50: 12 nM
99%
Zenidolol HCl
++++
β2-adrenergic receptor, Ki: 0.7nM
β1-adrenergic receptor, Ki: 611nM
98%
Acebutolol HCl
✔
97+%
Carteolol HCl
✔
98+%
Betaxolol
✔
99%
Betaxolol HCl
+
β1-adrenergic receptor, IC50: 6 μM
97%
Bisoprolol
✔
97%
Sotalol HCl
✔
95+%
Nebivolol HCl
+++
β1-adrenoceptor, IC50: 0.8 nM
99%
Metoprolol
✔
98+%
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
Scopine/东莨菪醇 生物活性
描述
Scopine is the metabolite of anisodine, which is a α1-adrenergic receptor agonist and is used in the treatment of acute circulatory shock. Chlorambucil (CHL), an alkylating agent, as the model therapeutic agent, and used scopine as a novel brain-targeting moiety. The tissue distribution study after i.v. injection revealed that the AUC0-t and Cmax of CHLS in the brain were 14.25- and 12.20-fold of CHL, respectively. Specifically, CHLS (Chlorambucil-Scopine) accumulated in bEnd.3 and C6 cells in an energy-dependent manner. In C6 cells, superior anti-glioma activity with a significantly decreased IC50 of 65.42 nM/mL was observed for CHLS compared to CHL (IC50 > 400 nM/mL). Scopine is a potential brain-targeting moiety for enhancing the brain uptake efficiency of CHL (chlorambucil)[3]
Scopine/东莨菪醇 参考文献
Scopine/东莨菪醇 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
6.44mL
1.29mL
0.64mL
32.22mL
6.44mL
3.22mL
64.44mL
12.89mL
6.44mL
Scopine/东莨菪醇 技术信息
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