Scopine
产品说明书
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同义名 : | 6,7-Epoxytropine |
| CAS号 : | 498-45-3 | |
| 货号 : | A578511 | |
| 分子式 : | C8H13NO2 | |
| 纯度 : | 98% | |
| 分子量 : | 155.19 | |
| MDL号 : | MFCD06658282 | |
| 存储条件： |
Pure form Inert atmosphere, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(676.57 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Scopine is the metabolite of anisodine, which is a α1-adrenergic receptor agonist and is used in the treatment of acute circulatory shock. Chlorambucil (CHL), an alkylating agent, as the model therapeutic agent, and used scopine as a novel brain-targeting moiety. The tissue distribution study after i.v. injection revealed that the AUC0-t and Cmax of CHLS in the brain were 14.25- and 12.20-fold of CHL, respectively. Specifically, CHLS (Chlorambucil-Scopine) accumulated in bEnd.3 and C6 cells in an energy-dependent manner. In C6 cells, superior anti-glioma activity with a significantly decreased IC50 of 65.42 nM/mL was observed for CHLS compared to CHL (IC50 > 400 nM/mL). Scopine is a potential brain-targeting moiety for enhancing the brain uptake efficiency of CHL (chlorambucil)[3]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
6.44mL 1.29mL 0.64mL |
32.22mL 6.44mL 3.22mL |
64.44mL 12.89mL 6.44mL |
| 参考文献 |
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