Carvedilol
产品说明书
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同义名 : | BM 14190; SKF 105517; carvedilol hydrochloride; Coropres; Querto; Kredex; Eucardic; Carvedilolum; Dilatrend; Coreg; Carvedilol (free base) |
| CAS号 : | 72956-09-3 | |
| 货号 : | A361863 | |
| 分子式 : | C24H26N2O4 | |
| 纯度 : | 98% | |
| 分子量 : | 406.47 | |
| MDL号 : | MFCD00864692 | |
| 存储条件： |
Pure form Keep in dark place, inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(258.32 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 靶点 |
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| 描述 | Carvedilol is a non-selective beta blocker/alpha-1 blocker with an IC50 of 3.8 μM for inhibition of LDL oxidation. | ||
| 细胞研究 | |||||
|---|---|---|---|---|---|
| 细胞系 | 浓度 | 检测类型 | 检测时间 | 活性说明 | 数据源 |
| BESM cells | Cytotoxicity assay | 88 h | Cytotoxicity against BESM cells after 88 hrs by HTS assay, EC50=31 μM | 20547819 | |
| CHO cells | Function assay | Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique, IC50=10.4713 μM | 18448342 | ||
| HEK293 cells | Function assay | 3 mins | Inhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay, IC50=7.5 μM | 23241029 | |
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT00374465 | Dilated Cardiomyopathy | Phase 4 | Unknown | - | Poland ... 展开 >> Silesian Centre for Heart Disease, 3rd Department of Cardiology Recruiting Zabrze, Szpitalna 2 st., Poland, 41800 Principal Investigator: Romuald Wojnicz, MD, PhD Sub-Investigator: Ewa N Kozielska, MD, PhD Sub-Investigator: Jolanta Nowak, MD Sub-Investigator: Krzysztof Wilczek, MD Sub-Investigator: Celina Wojciechowska, MD Sub-Investigator: Bozena Szygula, MD 收起 << |
| NCT01009918 | Breast Cancer ... 展开 >> Cardiac Toxicity 收起 << | Phase 2 | Active, not recruiting | November 2018 | - |
| NCT00384566 | Heart Failure ... 展开 >> Chronic Obstructive Airway Disease 收起 << | Phase 4 | Withdrawn(In order to join for... 展开 >>ces with another study already running which aims to answer the same question.) 收起 << | - | Australia, Victoria ... 展开 >> Alfred Hospital Melbourne, Victoria, Australia, 3004 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.46mL 0.49mL 0.25mL |
12.30mL 2.46mL 1.23mL |
24.60mL 4.92mL 2.46mL |
| 参考文献 |
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