Voreloxin HCl

产品说明书

Print
Chemical Structure| 175519-16-1 同义名 : AG 7352 Hydrochloride; Vosaroxin Hydrochloride; Vosaroxin; SNS-595 Hydrochloride; Voreloxin Hydrochloride
CAS号 : 175519-16-1
货号 : A405214
分子式 : C18H20ClN5O4S
纯度 : 98%
分子量 : 437.9
MDL号 : MFCD13185156
存储条件：

Pure form Inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 2 mg/mL(4.57 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 2 mg/mL(4.57 mM)，配合低频超声，并水浴加热至45℃助溶
生物活性
靶点

  • Topo II
描述 Voreloxin hydrochloride is a naphthyridine analogue with antineoplastic activity and an inhibitor of Topo II.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.28mL

0.46mL

0.23mL

11.42mL

2.28mL

1.14mL

22.84mL

4.57mL

2.28mL
参考文献

[1]Hoch U, Lynch J, et al. Voreloxin, formerly SNS-595, has potent activity against a broad panel of cancer cell lines and in vivo tumor models. Cancer Chemother Pharmacol. 2009 Jun;64(1):53-65.

[2]Tsuzuki Y, Tomita K, et al. Synthesis and structure-activity relationships of novel 7-substituted 1,4-dihydro-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acids as antitumor agents. Part 2. J Med Chem. 2004 Apr 8;47(8):2097-109.