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/ Primidone/普里米酮

Primidone/普里米酮 {[allProObj[0].p_purity_real_show]}

货号：A538446 同义名： 扑米酮;去氧苯比妥 / NSC 41701; NCI-C56360

Primidone是一种嘧啶二酮衍生物，具有抗惊厥活性。

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Primidone/普里米酮 化学结构 CAS号：125-33-7
Primidone/普里米酮 化学结构
CAS号：125-33-7
Primidone/普里米酮 3D分子结构
CAS号：125-33-7
Primidone/普里米酮 化学结构 CAS号：125-33-7
Primidone/普里米酮 3D分子结构 CAS号：125-33-7
规格 价格 会员价 库存 数量
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Primidone/普里米酮 纯度/质量文件 产品仅供科研

货号：A538446 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]
• Cell, 2025. Ambeed. [ A122167 ]
• Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]
• Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]
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更多 >
产品名称 GABA receptor ↓ GABAA receptor ↓ 其他靶点 纯度
Niflumic Acid ✔ 98%
Ginkgolide A ++

GABA receptor, Ki: 14.5 μM

 		98%
Valproic acid sodium ✔ HDAC,Autophagy 97%
Flumazenil ✔ 95%
Bemegride ✔ 98%
Bicuculline +++

GABAA receptor, IC50: 2 μM

 		99%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
产品名称 Sodium Channel ↓ 其他靶点 纯度
Tolperisone HCl ✔ 99%
Triamterene +++

ENaC, IC50: 4.5 μM

 		98%
Lamotrigine ✔ 98%
Vinpocetine ✔ 98%
Zonisamide ✔ 99%
Dronedarone HCl ✔ 95%
Procainamide HCl ✔ 99%
Bupivacaine HCl ✔ 99+%
Benzocaine ✔ 98%
Carbamazepine ++

Sodium channel, IC50: 131 μM

 		98%
Quinidine sulfate dihydrate ✔ 98%
Ibutilide fumarate ✔ 99%+
Dibucaine HCl ✔ 99+%
Mexiletine HCl ✔ 99%
Phenytoin ✔ 99+%
Camostat Mesylate +++

epithelial sodium channel (ENaC), IC50: 50 nM

 		99%+
Levobupivacaine ✔ 97+%
Oxcarbazepine +

sodium channel, IC50: 160 μM

 		98%
Amiloride HCl dihydrate ✔ 97%
Ambroxol 98+%
Primidone ✔ 99%
Propafenone ✔ 99%
A-803467 ++++

Na(V1.8) channel, IC50: 8 nM

 		99%+
Rufinamide ✔ 99%
Phenytoin sodium ✔ 98%
Proparacaine HCl +

Voltage-gated sodium channel, ED50: 3.4 mM

 		98+%
Amiloride HCl ✔ 98%
Riluzole ✔ 97%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Primidone/普里米酮 生物活性

靶点

  • Sodium Channel
描述 Primidone is a minor first-generation antiepileptic drug, and also remains a first-line treatment of essential tremor. Although it is metabolized in phenyl-ethyl-malondamide and phenobarbital, active metabolites that contribute also to its action, primidone is not a prodrug and is active by itself. Generally accepted therapeutic range for primidone is between 5 and 10 mg/L (23-46 mmol/L)[3]. Primidone, 50 to 1,000 mg/d, reduced the amplitude of essential tremor in both untreated and propranolol-treated patients. Low doses were as effective as high doses. Primidone decreased tremor more than propranolol. A single oral dose (250 mg) decreased tremor by 60% 1 to 7 hours after ingestion, with stable serum primidone levels. Tremor control was lost when phenobarbital was substituted for primidone shows primidone is an effective agent for the treatment of essential tremor[4].

Primidone/普里米酮 细胞实验

Cell Line
Concentration Treated Time Description References
Neural progenitor cells (NPCs) 5 μg/ml 5 days To assess the transcriptomic effect of primidone on neuronal and cerebellar cells, found primidone had a weak effect on transcription NPJ Genom Med. 2022 Aug 4;7(1):46
DAOY cells 5 μg/ml 5 days To assess the transcriptomic effect of primidone on neuronal and cerebellar cells, found primidone had a weak effect on transcription NPJ Genom Med. 2022 Aug 4;7(1):46
MEFs cells 1 mM 8 hours Primidone inhibits TNFα-induced cell death Cell Death Differ. 2021 May;28(5):1610-1626
L929 cells 1 mM 8 hours Primidone inhibits TNFα-induced necroptosis Cell Death Differ. 2021 May;28(5):1610-1626
NIH3T3 cells 1 mM 8 hours Primidone inhibits TNFα-induced necroptosis Cell Death Differ. 2021 May;28(5):1610-1626
HT-29 cells 1 mM 8 hours Primidone inhibits TNFα-induced activation of necrosome members RIPK1, RIPK3, and MLKL Cell Death Differ. 2021 May;28(5):1610-1626
U937 cells 1 mM 8 hours Primidone inhibits RIPK1-mediated necroptosis, reducing cell death Cell Death Differ. 2021 May;28(5):1610-1626

Primidone/普里米酮 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
C57BL/6J mice PregS- and heat-induced pain models, including inflammatory hyperalgesia Intraperitoneal injection 0.5, 2, 10 mg/kg Single administration, observation time up to 180 seconds To evaluate the inhibitory effect of primidone on chemically and thermally induced pain, results showed that primidone significantly reduced PregS- and heat-induced pain responses and attenuated inflammatory thermal hyperalgesia. Pain. 2017 May;158(5):856-867
ICR mice Tamoxifen-induced adenomyosis mouse model Intraperitoneal injection 2 mg/kg/d Once daily for 3 weeks To evaluate the therapeutic effects of primidone on tamoxifen-induced adenomyosis mice, results showed that primidone significantly reduced the depth of myometrial infiltration and had analgesic effects. Drug Des Devel Ther. 2025 Apr 2;19:2533-2549
Mice Kidney ischemia-reperfusion injury model Drinking water 2.875 mM Once daily for 5 days Primidone significantly reduced plasma urea and creatinine levels, protecting kidney tissue integrity Cell Death Differ. 2021 May;28(5):1610-1626
Mice ALS model Oral 25 mg/kg/day Once daily, from 10 weeks of age to the end-stage Primidone treatment delayed symptomatic onset, reduced body weight loss, and improved motor performance. Signal Transduct Target Ther. 2023 Dec 13;8(1):451

Primidone/普里米酮 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01771523 Goiter Not Applicable Completed - Turkey ... 展开 >> Maltepe University School of Medicine, General Surgery Department İstanbul, Turkey, 34843 收起 <<
NCT01816568 Acute Appendicitis Not Applicable Completed - -
NCT01772745 Gallbladder Disease Not Applicable Completed - -

Primidone/普里米酮 参考文献

[1]Macdonald RL, Kelly KM. Antiepileptic drug mechanisms of action. Epilepsia. 1995;36 Suppl 2:S2-12.

[2]Calzetti S, Findley LJ, et al. Phenylethylmalonamide in essential tremor. A double-blind controlled study. J Neurol Neurosurg Psychiatry. 1981 Oct;44(10):932-4.

[3]Bentué-Ferrer D, Verdier MC, Tribut O. Suivi thérapeutique pharmacologique de la primidone et du phénobarbital [Therapeutic drug monitoring of primidone and phenobarbital]. Therapie. 2012 Jul-Aug;67(4):381-90. French.

[4]Koller WC, Royse VL. Efficacy of primidone in essential tremor. Neurology. 1986 Jan;36(1):121-4.

Primidone/普里米酮 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.58mL

0.92mL

0.46mL

22.91mL

4.58mL

2.29mL

45.82mL

9.16mL

4.58mL

Primidone/普里米酮 技术信息

CAS号125-33-7
分子式C12H14N2O2
分子量 218.25
SMILES Code O=C(C1(CC)C2=CC=CC=C2)NCNC1=O
MDL No. MFCD00038662
别名 扑米酮;去氧苯比妥;扑痫酮;密苏林;美速林 ;NSC 41701; NCI-C56360; XcelBrand of Primidone; Sertan; Sanofi-Synthelabo Brand of Primidone; Resimatil; Mysoline; Mizodin; Mylepsinum; Primaclone
运输蓝冰
InChI Key DQMZLTXERSFNPB-UHFFFAOYSA-N
Pubchem ID 4909
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Sealed in dry, room temperature
溶解方案

DMSO: 50 mg/mL(229.09 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一
方案 二
方案 三

Tags: Primidone | 125-33-7 | Sodium Channel Inhibitor | Membrane Transporter/Ion Channel | Sodium Channel | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Primidone/普里米酮 纯度/质量文件 | Primidone/普里米酮 亚型比较 | Primidone/普里米酮 生物活性 | Primidone/普里米酮 临床数据 | Primidone/普里米酮 参考文献 | Primidone/普里米酮 实验方案 | Primidone/普里米酮 技术信息

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