GDC-0276是一种选择性且具有口服活性的 NaV1.7 抑制剂，IC₅₀ 值为 0.4 nM。它耐受性良好，并展示了优异的药代动力学特征。GDC-0276 主要用于研究疼痛和成瘾性相关的神经性疾病。

NS383是一种有效且独特的 ASICs 抑制剂，能够抑制与酸敏感离子通道相关的疼痛信号传导，适用于病理性疼痛的治疗研究。

Evenamide是一种口服有效的电压门控钠通道阻滞剂，具有显著的抗精神分裂症和抗精神病活性，尤其在精神病的动物模型中表现出显著功效。

盐酸丙氧卡因是丙氧卡因的盐酸盐形式，是一种具有局部麻醉活性的对氨基苯甲酸酯。

Flecainide Acetate is a class 1C antiarrhythmic drug especially used for the management of supraventricular arrhythmia and works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential.

GNE-131 is a potent and selective inhibitor of human sodium channel NaV1.7, with an IC50 of 3 nM.

Dyclonine HCl is the HCl form of dyclonine which can reversibly bind to activated sodium channels on the neuronal membrane. It is an anaesthetic found in sucrets.

PF-01247324 is a selective Nav1.8 channel blocker with an IC50 of 196 nM.

Indoxacarb是一种广谱恶二嗪类杀虫剂，具有高杀虫活性和低哺乳动物毒性，能够阻断昆虫钠通道。

NHE3-IN-1 is a sodium/proton exchanger type 3 (NHE-3) inhibitor extracted from patent WO 2011019784 A1.

DS-1971a是一种选择性、口服有效的 NaV1.7 抑制剂，对 hNaV1.7 和 mNaV1.7 的 IC50 分别为 22.8 和 59.4 nM，用于疼痛研究。

PF-04885614是一种有效的 NaV1.8 钠离子通道抑制剂，具有潜力用于神经系统和神经发育疾病的研究，适用于疼痛管理以及神经功能障碍的研究。

BIX NHE1 Inhibitor is a potent and selective NHE1 inhibitor with IC50 of 31 nM.

Ropivacaine HCl, a local anaesthetic, can reversibly inhibit sodium ion influx and block impulse propagation along nerve fibres.

Flecainide acetate, a class Ic antiarrhythmic agent, can block the Nav1.5 sodium channel and inhibit ryanodine receptor 2 (RyR2). It is used to prevent and treat tachyarrhythmias.

Ralfinamide mesylate is an blocker of Na+ channel with function of suppressing pain.

Nicainoprol is a sodium channels blocker which is used as an antiarrhythmic agent.

Licarbazepine, also known as BIA-2-005; GP-47779; LIC-477; LIC-477D; TRI-477, is a voltage-gated sodium channel blocker with anticonvulsant and mood-stabilizing effects that is related to oxcarbazepine. It is an active metabolite of oxcarbazepine. In addition, an isomer of licarbazepine, eslicarbazepine ((S)-(+)-licarbazepine), is an active metabolite of eslicarbazepine acetate. Oxcarbazepine and eslicarbazepine acetate are inactive on their own, and behave instead as prodrugs to licarbazepine and eslicarbazepine, respectively, to produce their therapeutic effects.

Carbamazepine is a blocker of sodium channel with IC50 of 131 μM in rat brain synaptosomes. It is an anticonvulsant drug.

ICA-121431 是一种纳摩尔级别强效广谱电压门控钠通道 (Nav) 阻滞剂，对人 Nav1.1 和 Nav1.3 亚型具有等效选择性，IC50s 小于20 nM，ICA-121431 对人Nav1.2 的抑制作用较弱 (IC50=240 nM)，而对人Nav1.4、Nav1.5、Nav1.6、Nav1.7和Nav1.8通道表现出大于 1000 倍的选择性(IC50s >10 µM)。ICA-121431可以抑制大鼠的Nav1.7通道（IC50=19nM）。