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货号 产品名 纯度
A752746 现货 Propoxycaine HCl/盐酸丙氧卡因

盐酸丙氧卡因是丙氧卡因的盐酸盐形式,是一种具有局部麻醉活性的对氨基苯甲酸酯。

99%+
A1181590 现货 Nav1.8-IN-4

Nav1.8-IN-4是 一种 Nav1.8 通道抑制剂,IC50 为 0.014 μM,可用于疼痛相关疾病的研究。

95%
A1942314 现货 Suzetrigine

Suzetrigine(VX-548)是一种口服活性的、高度选择性的NaV1.8抑制剂,具有镇痛性能。Suzetrigine 也是钠通道蛋白 10 型亚基 α 的阻断剂。

99%+
A268635 现货 Propafenone

Propafenone (SA-79) 是一种钠通道阻滞剂,具有抗心律失常作用。它还对β受体具有高亲和力(IC50=32 nM)。Propafenone通过诱导线粒体功能障碍和凋亡抑制食管癌增殖。

99%
A179082 现货 Ibutilide fumarate/富马酸伊布利特

Ibutilide (U70226E) fumarate是一种III类抗心律失常药物,可以延长动作电位。它作用于AT-1细胞,有效阻断快速激活的延迟整流钾电流(IKr)。

99%+
A785893 现货 GMQ/GMQ盐酸盐

95%
A1883229 现货 NaV1.2/1.6 channel blocker-1

99%+
A189693 现货 Disopyramide phosphate

98%
A102515 现货 Fosphenytoin disodium/磷苯妥英钠

Fosphenytoin (disodium) is the sodium salt form of fosphenytoin, a prodrug that is hydrolyzed to the anticonvulsant phenytoin upon parental administration.

99%+
A1371164 现货 Benzamil HCl

Benzamil hydrochloride is a specific blocker of sodium channel (ENaC).

98%
A1147312 现货 Rimeporide

Rimeporide is a potent and selective NHE1 inhibitor.

99%+
A393036 现货 PF-06869206

PF-06869206 is an orally bioavailable selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1) with an IC50 of 380 nM.

99%+
A555383 现货 Flecainide acetate/氟卡胺

Flecainide Acetate is a class 1C antiarrhythmic drug especially used for the management of supraventricular arrhythmia and works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential.

98%
A388262 现货 XEN907

XEN907 is a spirooxindole NaV1.7 blocker, inhibits hNaV1.7 with IC50 of 3 nM.

98+%
A196078 现货 Mepivacaine/N-(2,6-二甲基苯基)-1-甲基哌啶-2-甲酰胺

Mepivacaine is an amide-type local anesthetic agent. Mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization.

97%
A1176836 现货 GNE-131

GNE-131 is a potent and selective inhibitor of human sodium channel NaV1.7, with an IC50 of 3 nM.

98%
A162451 现货 Dyclonine HCl/盐酸达克罗宁

Dyclonine HCl is the HCl form of dyclonine which can reversibly bind to activated sodium channels on the neuronal membrane. It is an anaesthetic found in sucrets.

98%
A342947 现货 PF-01247324

PF-01247324 is a selective Nav1.8 channel blocker with an IC50 of 196 nM.

98%
A642597 现货 Eleclazine HCl

Eleclazine HCl is a late Na+ current inhibitor with IC50 value of 0.7 μM.

99%+
A195792 现货 PF 05089771

PF-05089771 is a Nav1.7 channel blocker with an IC50 of 8.6 nM.

99%+
产品名 Sodium Channel 其他靶点 纯度
Tolperisone HCl 99%
Lamotrigine 98%
Vinpocetine 98%
Zonisamide 98%
Dronedarone Hydrochloride 95%
Procainamide hydrochloride 99%
Bupivacaine HCl 99+%
Benzocaine 98%
Carbamazepine ++

Sodium channel, IC50: 131 μM

98%
Ibutilide fumarate 99%+
Dibucaine HCl 99+%
Mexiletine HCl 99%
Phenytoin 99+%
Camostat Mesylate +++

epithelial sodium channel (ENaC), IC50: 50 nM

99%+
Levobupivacaine 97+%
Oxcarbazepine +

sodium channel, IC50: 160 μM

98%
Ambroxol 98+%
Primidone 99%
Propafenone 99%
A-803467 ++++

Na(V1.8) channel, IC50: 8 nM

99%+
Rufinamide 99%
Phenytoin sodium 98%
Proparacaine Hydrochloride +

Voltage-gated sodium channel, ED50: 3.4 mM

98+%
Riluzole 97%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
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