Ginkgolide A/银杏内酯A
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货号：A581449
同义名：
BN-52020
Ginkgolide A是一种 GABA 受体拮抗剂，Ki 值为 14.5 μM，还可以激活 PAF。它从银杏树的叶子中提取纯化。
Ginkgolide A/银杏内酯A 化学结构
Ginkgolide A/银杏内酯A 3D分子结构
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Ginkgolide A/银杏内酯A 纯度/质量文件 产品仅供科研
货号：A581449
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Ginkgolide A/银杏内酯A 质控信息
Ginkgolide A/银杏内酯A 生物活性
靶点
描述
Ginkgolide A is a highly active platelet activating factor antagonist cage molecule which was isolated from the leaves of the Ginkgo biloba L. Ginkgolide A may be one of the potential therapeutic lead compounds, especially for the treatment of cardiovascular, hepatological, and neurological diseases and disorders[3] [4] [5] [6]
Ginkgolide A/银杏内酯A 细胞实验
Cell Line
Concentration
Treated Time
Description
References
Rat pulmonary microvascular endothelial cells (PMVECs)
5-10 μg/mL
22 hours
Inhibition of PMVEC apoptosis, significantly increased c-Myc mRNA expression and suppressed Bcl-2 mRNA reduction at 5-10 μg/mL concentration.
Biosensors (Basel). 2021 Aug 6;11(8):264
human aortic smooth muscle cells (HASMC)
50 μM GA
24 hours
To investigate the effect of GA on GABRA3 expression in HASMCs, results showed significant reduction in GABRA3 protein expression after GA treatment
Redox Biol. 2024 Nov;77:103397
differentiated THP-1 cells
0-20 μg/mL
24 hours
Inhibited LPS-induced COX-2 expression, downregulated pro-inflammatory cytokines TNF-α, IL-6, and IL-1β
Int J Mol Sci. 2017 Apr 10;18(4):794
RAW264.7 cells
0-20 μg/mL
24 hours
Inhibited LPS-induced COX-2 expression and NO production, downregulated pro-inflammatory cytokines TNF-α, IL-6, and IL-1β
Int J Mol Sci. 2017 Apr 10;18(4):794
mouse peritoneal macrophages
0-20 μg/mL
24 hours
Inhibited LPS-induced COX-2 expression and NO production, downregulated pro-inflammatory cytokines TNF-α, IL-6, and IL-1β
Int J Mol Sci. 2017 Apr 10;18(4):794
Wharton's Jelly-derived mesenchymal stem cells (WJMSCs)
80 µM
5 days
To evaluate the effect of GA on WJMSCs proliferation, results showed that GA promoted WJMSCs proliferation.
Aging (Albany NY). 2023 Feb 20;15(5):1358-1370
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Ginkgolide A/银杏内酯A 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Mice
AngII-induced AAA model and Ca3(PO4)2-induced AAA model
Intragastric administration
100 mg/kg body weight
Once daily for 28 days
To investigate the protective effect of GA on AAA formation, results showed GA treatment significantly suppressed AAA formation and progression
Redox Biol. 2024 Nov;77:103397
BALB/c mice
LPS-induced inflammation model
Intraperitoneal injection
20 mg/kg
Single dose, samples collected after 2 hours
Inhibited LPS-induced TNF-α and IL-6 production, activated AMPK signaling pathway
Int J Mol Sci. 2017 Apr 10;18(4):794
C57BL6/J mice
Traumatic brain injury (TBI) model
Intraperitoneal injection
5 mg/kg
Once daily for 7 days
Ginkgolide A improved neurological deficits in TBI mice by reducing oxidative stress and inhibiting apoptosis
Heliyon. 2024 Jan 14;10(2):e24759
C57BL/6 mice
DCF1-knockout mice
Intraperitoneal injection
10 mg/kg body weight
For 5 consecutive days
Inhibition of GABA partially rescued the visual deficit in DCF1-KO mice
Neurosci Bull. 2018 Jun;34(3):465-475
C57BL/6 mice
CCl4-induced hepatitis and colitis model
Oral gavage
50-200 mg/kg/day
Once daily for 3 days
Ginkgolide A significantly alleviated CCl4-induced hepatitis and colitis, reduced serum ALT and AST levels in a dose-dependent manner.
Biomol Ther (Seoul). 2016 Jan;24(1):40-8
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Ginkgolide A/银杏内酯A 临床研究
NCT号
适应症或疾病
临床期
招募状态
预计完成时间
地点
NCT03772847
Intravenous Alteplase Thrombol... 展开 >> ysis
Neurological Improving 收起 <<
Phase 4
Recruiting
December 1, 2019
China, Zhejiang
... 展开 >>
Min Lou
Recruiting
Hangzhou, Zhejiang, China, 310000
Contact: Zexin Chen 13757118366 HREC2013@126.com 收起 <<
NCT02425436
Intrauterine Growth Restrictio... 展开 >> n (IUGR) 收起 <<
Phase 2
Completed
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Ginkgolide A/银杏内酯A 参考文献
[1] Zhou H, Gao J, et al. Ginkgolide B inhibits renal cyst development in in vitro and in vivo cyst models. Am J Physiol Renal Physiol. 2012 May 15;302(10):F1234-42.
[2] Wada K, Sasaki K, et al. Isolation of bilobalide and ginkgolide A from Ginkgo biloba L. shorten the sleeping time induced in mice by anesthetics. Biol Pharm Bull. 1993 Feb;16(2):210-2.
[3] Sarkar C, Quispe C, Jamaddar S, Hossain R, Ray P, Mondal M, Abdulwanis Mohamed Z, Sani Jaafaru M, Salehi B, Islam MT, Faizal Abdull Razis A, Martorell M, Pastene-Navarrete E, Sharifi-Rad J. Therapeutic promises of ginkgolide A: A literature-based review. Biomed Pharmacother. 2020 Dec;132:110908.
[4] Mohandas S, Vairappan B. Ginkgolide-A attenuates bacterial translocation through activating PXR and improving antimicrobial peptide Reg 3A in experimental cirrhosis. Life Sci. 2020 Sep 15;257:118111.
[5] Li Y, Wu Y, Yao X, Hao F, Yu C, Bao Y, Wu Y, Song Z, Sun Y, Zheng L, Wang G, Huang Y, Sun L, Li Y. Ginkgolide A Ameliorates LPS-Induced Inflammatory Responses In Vitro and In Vivo. Int J Mol Sci. 2017 Apr 10;18(4):794.
[6] Jeong HS, Kim KH, Lee IS, Park JY, Kim Y, Kim KS, Jang HJ. Ginkgolide A ameliorates non-alcoholic fatty liver diseases on high fat diet mice. Biomed Pharmacother. 2017 Apr;88:625-634.
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Ginkgolide A/银杏内酯A 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.45mL
0.49mL
0.24mL
12.24mL
2.45mL
1.22mL
24.49mL
4.90mL
2.45mL
Ginkgolide A/银杏内酯A 技术信息
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