There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Camostat mesylate (CM) is a trypsin-like protease inhibitor, inhibits airway epithelial sodium channel (ENaC) function with IC50 of 50 nM, less potent to trypsin, prostasin and matriptase. It also inhibits transmembrane serine protease TMPRSS2, suggesting that it could block entry of SARS-Cov-2 (COVID-19) into lung cells in vitro[3]. In vivo, the oral administration of CM inhibited inflammation, cytokines expression and fibrosis in the pancreas. CM inhibited both MCP-1 (monocyte chemoattractant protein-1) and TNF-alpha production from monocytes, and proliferation and MCP-1 production from PSCs (panceatic stellate cells) [4]. Camostat mesilate (30 mg/kg; p.o.; twice a day for 9 days) blocks the spread and pathogenesis of SARS-CoV in a pathogenic mouse model[5]. CM alleviated the detrimental effect of LPS on cell viability and inhibited LPS-induced TNF-α and IL-6 secretions in DF-1 chicken embryo fibroblasts[6].
Camostat Mesylate/甲磺酸卡莫司他 细胞实验
Cell Line
Concentration
Treated Time
Description
References
PK
10.4 nM (IC50)
Determination of Camostat's inhibitory effect on PK, IC50 of 10.4 nM
J Virol. 2021 Sep 9;95(19):e0086121.
HEK-293T
142 nM (IC50)
Confirm Camostat inhibits TMPRSS2 activity
Chem Sci. 2020 Nov 13;12(3):983-992.
Cathepsin G (CatG)
80 µg/mL
1 hour
Analyze the inhibitory capacity of camostat towards CatG proteolytic activity
Pharmaceuticals (Basel). 2022 Apr 20;15(5):500.
Proteinase 3 (PR3)
0 to 1000 µM
15 minutes
Analyze the inhibitory capacity of camostat towards PR3 proteolytic activity
Pharmaceuticals (Basel). 2022 Apr 20;15(5):500.
Proteinase 3 (PR3)
40 µg/mL
15 minutes
Analyze the inhibitory capacity of camostat towards PR3 proteolytic activity
Pharmaceuticals (Basel). 2022 Apr 20;15(5):500.
Neutrophil Elastase (NE)
40 µg/mL
15 minutes
Analyze the inhibitory capacity of camostat towards NE proteolytic activity
Pharmaceuticals (Basel). 2022 Apr 20;15(5):500.
Calu-3 cells
0.01, 0.1, 1, 10, 100 µM
2 hours
Evaluate the inhibitory effect of Camostat mesylate on SARS-2-S-driven cell entry
EBioMedicine. 2021 Mar;65:103255.
BHK-21 cells
100 µM
2 hours
Evaluate the inhibitory effect of Camostat mesylate on SARS-2-S-driven cell entry
EBioMedicine. 2021 Mar;65:103255.
Primary human lung cells
1-500 µM
2 hours pretreatment
To evaluate the importance of TMPRSS2 for SARS-2-S-driven cell entry, camostat mesylate significantly reduced SARS-2-S-driven entry
Cell. 2020 Apr 16;181(2):271-280.e8.
Calu-3 cells
1-500 µM
2 hours pretreatment
To evaluate the importance of TMPRSS2 for SARS-2-S-driven cell entry, camostat mesylate significantly reduced SARS-2-S-driven entry
Cell. 2020 Apr 16;181(2):271-280.e8.
Vero-TMPRSS2 cells
1-500 µM
2 hours pretreatment
To evaluate the importance of TMPRSS2 for SARS-2-S-driven cell entry, camostat mesylate partially blocked SARS-2-S-driven entry
Cell. 2020 Apr 16;181(2):271-280.e8.
Caco-2 cells
1-500 µM
2 hours pretreatment
To evaluate the importance of TMPRSS2 for SARS-2-S-driven cell entry, camostat mesylate partially blocked SARS-2-S-driven entry
Cell. 2020 Apr 16;181(2):271-280.e8.
Trypsin
9.3 nM (IC50)
Determination of Camostat's inhibitory effect on trypsin, IC50 of 9.3 nM
J Virol. 2021 Sep 9;95(19):e0086121.
Matriptase
21.1 nM (IC50)
Determination of Camostat's inhibitory effect on matriptase, IC50 of 21.1 nM
J Virol. 2021 Sep 9;95(19):e0086121.
FXIa
44.1 nM (IC50)
Determination of Camostat's inhibitory effect on FXIa, IC50 of 44.1 nM
J Virol. 2021 Sep 9;95(19):e0086121.
MuPA
100.4 nM (IC50)
Determination of Camostat's inhibitory effect on muPA, IC50 of 100.4 nM
J Virol. 2021 Sep 9;95(19):e0086121.
UPA
86.4 nM (IC50)
Determination of Camostat's inhibitory effect on uPA, IC50 of 86.4 nM
J Virol. 2021 Sep 9;95(19):e0086121.
Camostat Mesylate/甲磺酸卡莫司他 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Mice
Pancreatic growth model
Oral
400 mg/kg/day
Once daily for 10 days
To assess the effects of camostate on pancreatic growth and plasma CCK concentration in mice. The results showed that chronic camostate feeding significantly increased pancreatic weight, protein and DNA content, and markedly elevated plasma CCK concentration.
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