Amiloride HCl dihydrate/盐酸阿米洛利二水合物
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货号：A105627
同义名：
MK-870 hydrochloride dihydrate; Amiloride hydrochloride dihydrate
Amiloride HCl blocks epithelial sodium channel (ENaC) and is used to treat hypertension and congestive heart failure.
Amiloride HCl dihydrate/盐酸阿米洛利二水合物 化学结构
Amiloride HCl dihydrate/盐酸阿米洛利二水合物 3D分子结构
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Amiloride HCl dihydrate/盐酸阿米洛利二水合物 纯度/质量文件 产品仅供科研
货号：A105627
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• Science , 2025, 387(6729): eadp5637. Ambeed. • Nat. Electron. , 2025, 8, 66-74. Ambeed. • Adv. Mater. , 2025, 2416621. Ambeed. • Adv. Mater. , 2025, 2410493. Ambeed. • Adv. Mater. , 2025, 2420319. Ambeed. A106129
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Amiloride HCl dihydrate/盐酸阿米洛利二水合物 质控信息
Amiloride HCl dihydrate/盐酸阿米洛利二水合物 生物活性
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Amiloride is a potent epithelial sodium channel (ENaC) blocker, used in the management of hypertension and congestive heart failure. It works as both a selective T-type calcium channel/epithelial sodium channel blocker, and a selective inhibitor of urokinase plasminogen activator (uPA). Amiloride selectively blocked the low threshold calcium channel in mouse neuroblastoma and chick dorsal root ganglion neurons[5] [6] [7] [8]
Amiloride HCl dihydrate/盐酸阿米洛利二水合物 参考文献
[1] Tang CM, Presser F, Morad M. Amiloride selectively blocks the low threshold (T) calcium channel. Science. 1988;240(4849):213-5
[2] Bhagatwala J, Harris RA, Parikh SJ, et al. Epithelial sodium channel inhibition by amiloride on blood pressure and cardiovascular disease risk in young prehypertensives. J Clin Hypertens (Greenwich). 2014;16(1):47-53
[3] Vassalli JD, Belin D. Amiloride selectively inhibits the urokinase-type plasminogen activator. FEBS Lett. 1987;214(1):187-91
[4] Xu LB, Chi N, Shi W. Amiloride, a urokinase-type plasminogen activator receptor (uTPA) inhibitor, reduces proteinurea in podocytes. Genet Mol Res. 2015;14(3):9518-29
[5] Tang CM, Presser F, Morad M. Amiloride selectively blocks the low threshold (T) calcium channel. Science. 1988 Apr 8;240(4849):213-5. doi: 10.1126/science.2451291. PMID: 2451291.
[6] Bhagatwala J, Harris RA, Parikh SJ, Zhu H, Huang Y, Kotak I, Seigler N, Pierce GL, Egan BM, Dong Y. Epithelial sodium channel inhibition by amiloride on blood pressure and cardiovascular disease risk in young prehypertensives. J Clin Hypertens (Greenwich). 2014 Jan;16(1):47-53. doi: 10.1111/jch.12218. Epub 2013 Oct 31. PMID: 24410943; PMCID: PMC8031874.
[7] Vassalli JD, Belin D. Amiloride selectively inhibits the urokinase-type plasminogen activator. FEBS Lett. 1987 Apr 6;214(1):187-91. doi: 10.1016/0014-5793(87)80039-x. PMID: 3106085.
[8] Xu LB, Chi N, Shi W. Amiloride, a urokinase-type plasminogen activator receptor (uTPA) inhibitor, reduces proteinurea in podocytes. Genet Mol Res. 2015 Aug 14;14(3):9518-29. doi: 10.4238/2015.August.14.15. PMID: 26345885.
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Amiloride HCl dihydrate/盐酸阿米洛利二水合物 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
3.31mL
0.66mL
0.33mL
16.55mL
3.31mL
1.66mL
33.10mL
6.62mL
3.31mL
Amiloride HCl dihydrate/盐酸阿米洛利二水合物 技术信息
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