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货号 产品名 纯度
A453417 现货 Broflanilide/氟苯双酰胺

Broflanilide 是一种潜在的杀虫剂,其代谢产物 desmethyl-broflanilide 是一种昆虫抗杀虫剂 (RDL) GABA 受体的强效拮抗剂,抑制小菜蛾 RDL GABA 受体,IC50 值为 1.3 nM。

99%
A222609 现货 L-655708

L-655708是一种有效的、选择性的GABAA受体逆激动剂,其Ki为0.45 nM。

99%
A1209230 现货 ZAPA sulfate

ZAPA sulfate 是一种低亲和力的 GABAA 受体激动剂,在蛔虫肌肉细胞中诱导膜超极化,EC50 为 10.3 μM。

98%
A196707 现货 Guvacine HCl/盐酸去甲槟榔次碱

Guvacine hydrochloride是从槟榔中提取的一种生物碱,是GABA转运体的抑制剂,对几种克隆的GABA转运体具有适度的选择性,其IC50值分别为14 μM(人类GAT-1)、39 μM(大鼠GAT-1)、58 μM(大鼠GAT-2)、119 μM(人类GAT-3)、378 μM(大鼠GAT-3)和1870 μM(人类BGT-3)。

95%
A402358 现货 Jujuboside A/酸枣仁皂苷 A

Jujuboside A, a natural product isolated and purified from the seeds of Zizyphus jujuba with neurophysiological inhibitory effects, performs its specific sedative and hypnotic effect through not only adjusting GABA receptors subunit mRNAs expression, but also down-regulating the secretion of relevant inflammation cytokines on the intestinal mucosal system to affect the intercellular cytokine network between nerve cells in the brain and may serve as a potential therapeutic agent for the treatment of Alzheimer׳s disease.

98%
A940558 现货 2'MeO6MF

99%
A673369 现货 Etbicyphat

98%+
A190802 现货 Baclofen/巴氯芬

Baclofen, a gamma-amino-butyric acid derivative, is a selective GABAB agonist with IC50 of 200 nM which used as a skeletal muscle relaxant.

98%
A885418 现货 CGP52432

CGP52432 is an antagonist of GABAB receptor with an IC50 of 85 nM.

99%+
A187150 现货 Sanggenon D/桑根酮D

Sanggenon D, a natural product isolated and purified from the root bark of Morus alba L.

95%
A899895 现货 MRK-016

MRK-016 is a functionally selective, inverse agonist at the benzodiazepine site of GABAA α5 receptors.

98%
A864319 现货 SKF89976A HCl

SKF-89976A HCl is a selective GABA transporter (GAT-1) inhibitor with IC50s of 0.28 μM, 137.34 μM and 202.8 μM for GAT-1, GAT-2 and GAT-3 in CHO cells, respectively.

95%
A319145 现货 CL 218872

CL 218872 is an agonist of benzodiazepine which displaying selectivity for α1 subunit-containing GABAA receptors with Ki values are 130, 1820, 1530, > 10000, 490 and > 10000 nM for α1, α2, α3, α4, α5 and α6-subunit containing receptors respectively.

98%+
A660802 现货 Gelsemine/钩吻碱

Gelsemine a natural indole alkaloid isolated from flowering plants of the genus Gelsemium with potent activity as an agonist of the mammalian glycine receptor, showing effect on pathways/systems related to xenobiotic- or diet-induced oxidative stress, and in the treatment of anxiety and other conditions.

95%
A202497 现货 Imepitoin

AWD 131-138 is a partial agonist of benzodiazepine receptor with effective anticonvulsant and anxiolytic properties.

99%+
A106679 现货 Basmisanil

Basmisanil is a selective modulator of GABAAα5 with negative allosteric regulation.

99%+
A423241 现货 Flumazenil/氟马西尼

Flumazenil is a non-selective antagonist of benzodiazepine towards α1, α2, α3 or α5-containing GABAA receptors.

95%
A1001459 现货 Loreclezole

Loreclezole is a subtype-selective GABAA receptor modulator. Acts as a positive allosteric modulator of β2 or β3-subunit containing receptors.

99%+
A112278 现货 U93631

U93631 is a ligand of GABAA receptor ligand (IC50 = 100 nM) which can induce a rapid decay of GABA-induced chloride currents.

99%+
A214929 现货 Tiagabine HCl/盐酸噻加宾

Tiagabine HCl is an inhibitor of gamma-aminobutyric acid (GABA) reuptake (IC50 = 67 nM in vivo) with anticonvulsant effect.

99%+
产品名 GABA receptor GABAA receptor 其他靶点 纯度
Niflumic Acid 98%
Ginkgolide A ++

GABA receptor, Ki: 14.5 μM

98%
Valproic acid sodium HDAC,Autophagy 97%
Flumazenil 95%
Bemegride 98%
Bicuculline +++

GABAA receptor, IC50: 2 μM

98+%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
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