Carbamazepine is an orally active anticonvulsant known for its ability to block pressure-sensitive sodium ion channels, with an IC50 of 131 μM. It inhibits not only voltage-gated Na+, Ca2+, and K+ channels but also acts as an HDAC inhibitor with an IC50 of 2 μM. It is utilized in the research of epilepsy and neuropathic pain[1].[2].[3].
体内研究
In animal models, a dose of 250 mg/kg administered orally promotes liver regeneration and increases survival in mice undergoing partial hepatectomy (PHx)[6].
Additionally, Carbamazepine included in food at concentrations between 0.25% to 0.75% demonstrates mood-stabilizing effects in various mouse models, including ICR and C57BL/6 mice[7].
体外研究
In cellular studies, Carbamazepine at concentrations ranging from 0 to 500 μM over 10 days inhibits pre-adipocyte differentiation and reduces triglyceride accumulation over 7 days in cell lines such as 3T3-L1, 3T3-F442A, and T37i[4].
At concentrations between 5 to 20 μM, administered 15 minutes before exposure to lipopolysaccharide (LPS), it significantly reduces the production of nitric oxide (NO), inducible nitric oxide synthase (iNOS) protein, and phosphorylation of Akt in microglial (BV-2) cells[5].
Furthermore, at 20 μM, Carbamazepine inhibits LPS-induced expression of COX-2 and production of TNF-α in the same cells[5].
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