There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Olanzapine is a D2 dopamine receptor antagonist with a high affinity for 5-HT2 serotonin. In vivo, sequential doses of olanzapine at 0.5, 3 and 10 mg/kg dose-dependently increased the extracellular dopamine (DA) and norepinephrine (NE) levels in all three brain areas. The increases appeared 30 min after olanzapine administration, reached peaks around 60 - 90 min and lasted for at least 2 h[3]. The high dose of olanzapine (10 mg/kg ) increased the number of fos-like positive nuclei in mesolimbic areas connected to the extended amygdala[4]. In vitro, olanzapine interacted with keyreceptorsof interest in schizophrenia, exihibiting a nanomolar affinity for dopaminergic, serotonergic, alpha 1-adrenergic, and muscarinic receptors[5].
Olanzapine inhibited insulin-stimulated glucose uptake over time, reaching maximum inhibition at 48 hours
Sci Rep. 2019 Feb 7;9(1):1582.
HEK293T cells
150 µM
24 hours
To evaluate the effect of olanzapine on mitophagy, results showed that olanzapine decreased the formation of mitolysosomes.
Aging Cell. 2023 Nov;22(11):e14003.
HEK293T cells
150 µM
24 hours
To evaluate the effect of olanzapine on mitochondrial parameters, results showed that olanzapine increased mitochondrial ROS levels, mitochondrial contents, and mitochondrial membrane potential.
Aging Cell. 2023 Nov;22(11):e14003.
PC12 cells
0, 10, 20, 40 µM
24 hours
To investigate whether olanzapine activated AMPK, results showed that olanzapine increased the phosphorylation of AMPK in both dose- and time-dependent manners
Acta Pharmacol Sin. 2020 Apr;41(4):508-515.
U87 cells
0-400 µM
24, 48, 72 hours
Evaluate the inhibitory effects of olanzapine on the growth of glioma cells, showing that olanzapine significantly inhibits the growth of glioma cells in a dose- and time-dependent manner.
CNS Neurosci Ther. 2019 Sep;25(9):911-921.
LN229 cells
0-400 µM
24, 48, 72 hours
Evaluate the inhibitory effects of olanzapine on the growth of glioma cells, showing that olanzapine significantly inhibits the growth of glioma cells in a dose- and time-dependent manner.
CNS Neurosci Ther. 2019 Sep;25(9):911-921.
T98 cells
0-400 µM
24, 48, 72 hours
Evaluate the inhibitory effects of olanzapine on the growth of glioma cells, showing that olanzapine significantly inhibits the growth of glioma cells in a dose- and time-dependent manner.
CNS Neurosci Ther. 2019 Sep;25(9):911-921.
MIN6 cells
10-50 µM
4 hours or 14 hours
Olanzapine inhibited glucose-stimulated insulin secretion in a concentration-dependent manner
Elife. 2020 Nov 17;9:e60970.
PC12 cells
20 µM
48 hours
To investigate the effect of olanzapine on autophagy, results showed that olanzapine induced autophagy and increased autophagic vacuoles
Acta Pharmacol Sin. 2020 Apr;41(4):508-515.
3T3-L1 adipocytes
0, 1, 2, 5, or 10 µM
48 hours
Olanzapine dose-dependently inhibited insulin-stimulated glucose uptake, increased NF-κB activity and decreased IκBα protein expression
Sci Rep. 2019 Feb 7;9(1):1582.
Olanzapine/奥氮平 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Balb/c mice and Sprague Dawley rats
Insulin resistance model
Intraperitoneal injection
10 mg/kg
Once daily for 8 weeks
Chronic olanzapine treatment caused metabolic symptoms, including insulin resistance, by markedly elevating plasma pro-inflammatory cytokine levels
Sci Rep. 2019 Feb 7;9(1):1582.
Caenorhabditis elegans
Wild-type N2
Administered via NGM medium
25, 50, 100, 150, 300 μM
From the L4 larval stage until death
To evaluate the effect of olanzapine on lifespan, results showed that olanzapine significantly shortened the lifespan of C. elegans.
Aging Cell. 2023 Nov;22(11):e14003.
Mice
BALB/c mice
Oral
3 mg/kg/day or 10 mg/kg/day
Once a day for 1-6 weeks
Olanzapine induced proinsulin misfolding in mouse islets
Elife. 2020 Nov 17;9:e60970.
Female Sprague-Dawley rats
Methylazoxymethanol (MAM)-induced neurodevelopmental model of schizophrenia
Intramuscular injection
5 mg/kg
Acute administration, observed over 24 hours
To investigate the acute metabolic effects of olanzapine and haloperidol in the MAM model, finding that olanzapine induced pronounced serum lipid profile alterations in MAM rats, while haloperidol had weaker metabolic effects.
CNS Neurosci Ther. 2024 Feb;30(2):e14565
Wistar rats
Chronic social isolation model
Intraperitoneal injection
7.5 mg/kg/day
Once daily for 3 weeks
To investigate the effects of Olz on the number of PV+ and GAD67+ cells in the hippocampus of CSIS rats and its antioxidative and anti-inflammatory potential. Olz reversed CSIS-induced depressive-like behavior, increased the number of GAD67+ cells in the SO and SP layers of dCA1, reduced the number of PV+ and GAD67+ cells in the SR layer of dCA3, and modulated oxidative stress and inflammatory markers.
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