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货号 产品名 纯度
A219168 RU 24969 hemisuccinate/半琥珀酸盐

97%
A1228907 (S)-Volinanserin

98%+
A1678530 5-HT3 antagonist 5

99%+
A1154387 (Rac)-Rotigotine

97%
A601317 SB 204741

SB 204741 is potent and selective 5-HT2B receptor antagonist (pA2 = 7.95). It displays ≥ 135-fold selectivity over 5-HT2C (pKi = 5.82), 5-HT2A (pKi < 5.2), 5-HT1A, 1D, 1E, 5-HT3 and 5-HT4 receptors.

99%+
A185815 RU 24969

RU 24969 is a selective agonist of the 5-HT1A and 5-HT1B receptors.

98%+
A685542 Clozapine N-oxide/氯氮平N-氧化物

Clozapine N-oxide is a major metabolite of clozapine noted to decrease SR-2A(5-HT2 serotonin receptor) density in vitro.

99%
A654799 RS-127445

RS 127445 is a potent and selective antagonist at 5-HT2B receptor with pKi value of 9.5.

98%+
A189213 Ritanserin/利坦色林

Ritanserin is a serotonin receptor antagonist which was never marketed for clinical use but has been used in scientific research.

99+%
A333393 Aripiprazole Lauroxil

Aripiprazole lauroxil is a long-acting injectable atypical antipsychotic. It is an N-acyloxymethyl prodrug of aripiprazole that is administered via intramuscular injection once every four to six weeks for the treatment of schizophrenia.

99%+
A798375 CP94253 HCl

CP 94253 HCl is a potent, selective 5-HT1B agonist with Ki of 2 nM.

98%+
A235837 Temanogrel

Temanogrel is a highly selective 5-HT2A receptor antagonist with Ki of 4.9 nM.

98%+
A192115 PRX-08066

PRX-08066 is a novel 5-HT2B receptor antagonist with IC50 of 3.4 nM.

98%+
A536132 VUF10166

VUF10166 is a potent and competitive antagonist for 5-HT3A receptor with Ki of 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower.

99%+
A599861 RS-127445 HCl

RS-127445 is a selective, high affinity and orally bioavailable serotonin 5-HT2B receptor antagonist. RS-127445 is found to have nanomolar affinity for the 5-HT2B receptor (pKi=9.5) and 1,000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites.

99%+
A973943 SB-215505

SB215505 is a potent 5-HT2B/2C receptor antagonist (pKi values are 8.3, 7.66 and 6.77 for 5-HT2B, 5-HT2C and 5-HT2A respectively). It Increases wakefulness and motor activity in rats.

98%+
A1177359 F-15599

F-15599 is a highly selective G-protein biased 5-HT1A receptor agonist with Ki value of 3.4nM.

99%+
A183212 Trimipramine maleate/三甲丙咪嗪马来酸盐

Trimipramine maleate is a serotonin transport and norepinephrine uptake blocker, is a tricyclic antidepressant (TCA) with antipsychotic and sedative properties.

99%
A461493 Blonanserin/布南色林

Blonanserin is a D2/5-HT2 receptor antagonist, atypical antipsychotic.

98% HPLC
A156606 Dehydroaripiprazole

Dehydroaripiprazole (OPC-14857) is an active metabolite of Aripiprazole. Aripiprazole is an antipsychotic agent and is metabolized by CYP3A4 and CYP2D6 forming mainly Dehydroaripiprazole. Dehydroaripiprazole has with antipsychotic activity equivalent to Aripiprazole.

97%
产品名 5-HT 5-HT1 5-HT2 5-HT3 5-HT5 5-HT6 5-HT7 其他靶点 纯度
Desvenlafaxine ++

5-HT, Ki: 40.2 nM

98%
Lamotrigine +

5-HT (rat brain synaptosomes), IC50: 474 μM

5-HT (human platelets), IC50: 240 μM

98%
Venlafaxine 98%
Fluvoxamine maleate 99%
Iloperidone 98%
Ziprasidone HCl 98+%
Atomoxetine HCI +

5-HT, Ki: 77 nM

98%
Dapoxetine HCl 97%
Trazodone 98+%
Clomipramine HCl 98%
Mirtazapine 99+%
Escitalopram oxalate +++

5-HT, Ki: 0.89 nM

97%
Duloxetine 98+%
Sertraline HCl ++

5-HT, Ki: 13 nM

98%
Citalopram HBr +++

serotonin reuptake, IC50: 1.8 nM

98%
WAY-100635 maleate +++

5-HT, IC50: 0.95 nM

99%
Latrepirdine 2HCl GluR 98%
Fluoxetine hydrochloride 98%
Paroxetine hydrochloride AChR 97%
BMY 7378 ++

5-HT1D, pIC50: 5.9

5-HT1A, pIC50: 6.4

+

5-HT2, pIC50: 5.5

97%
Flibanserin +++

5-HT1A, Ki: 1 nM

+

5-HT2A, Ki: 49 nM

98%
LY310762 +

5-HT1D, Ki: 249 nM

99%+
Cyclobenzaprine HCI 99%
Blonanserin +++

5-HT2, Ki: 3.98 nM

98% HPLC
Cyproheptadine HCl ++++

5-HT2, IC50: 0.6 nM

99+%
Olanzapine 99+%
Pimavanserin hemitartrate +++

5-HT2A, pIC50: 8.7

99%
Ketanserin +++

5-HT2C (Human), Ki: 2.5 nM

5-HT2C (Rat), Ki: 50 nM

99%+
Loxapine succinate ++

5-HT2 (bovine), Ki: 6.6 nM

5-HT2 (human), Ki: 6.8 nM

99%
Agomelatine 98%
Clozapine 98%
Amitriptyline +

5-HT2, Ki: 235 nM

SERT 98%
PRX-08066 maleate +++

5-HT2B, IC50: 3.4 nM

98+%
RS-127445 ++++

5-HT2B, pIC50: 10.4

5-HT2B, pKi: 9.5

98%+
Sarpogrelate HCl ++++

5-HT2C, Kd: 1.1 nM

5-HT2A, Kd: 2.1 nM

98%
Tropisetron 99%
Palonosetron 98+%
Ramosetron HCl ++++

5-HT3 receptor, Ki: 0.091 nM

98%
Ondansetron 99%
Granisetron 98%
Alosetron HCl 98%
Ondansetron hydrochloride dihydrate 98%
VUF10166 ++++

5-HT3AB, Ki: 22 nM

5-HT3A, Ki: 0.04 nM

99%+
Azasetron hydrochloride ++++

5-HT3, IC50: 0.33 nM

98%
Asenapine maleate +++

5-HT1B, pKi: 8.4

5-HT1A, pKi: 8.6

++++

5-HT2C, pKi: 10.46

5-HT2A, pKi: 9.75

+++

5-HT5A, pKi: 8.84

++++

5-HT6, pKi: 9.6

++++

5-HT7, pKi: 9.94

97%
Risperidone ++

5-HT1B, Ki: 14.9 nM

5-HT1D, Ki: 84.6 nM

++++

5-HT2A, Ki: 61.9 nM

5-HT2C, Ki: 12 nM

+

5-HT5A, Ki: 206 nM

++

5-HT7, Ki: 6.6 nM

98%
SB 271046 HCl +++

5-HT6, pKi: 8.92

99%+
Intepirdine ++++

5-HT6, pKi: 9.63

99%+
SB-269970 HCl ++

5-HT7, pKi: 8.3

98+%
BRL 15572 ++

5-HT1D, pKi: 6

5-HT1B, pKi: 6.1

++

5-HT2A, pKi: 6.6

5-HT2B, pKi: 6.2

+

5-HT6, pKi: 5.9

+

5-HT7, pKi: 6.3

98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
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