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/ Sertraline HCl/盐酸舍曲林

Sertraline HCl/盐酸舍曲林 {[allProObj[0].p_purity_real_show]}

货号：A217943 同义名： Sertraline (hydrochloride); CP-51974-1 HCl

Sertraline HCl是一种选择性的5-HT再摄取抑制剂（SSRI），其Ki值为13 nM，用于研究抑郁症等情绪障碍。

Sertraline HCl/盐酸舍曲林 化学结构 CAS号：79559-97-0
Sertraline HCl/盐酸舍曲林 化学结构
CAS号：79559-97-0
Sertraline HCl/盐酸舍曲林 3D分子结构
CAS号：79559-97-0
Sertraline HCl/盐酸舍曲林 化学结构 CAS号：79559-97-0
Sertraline HCl/盐酸舍曲林 3D分子结构 CAS号：79559-97-0
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Sertraline HCl/盐酸舍曲林 纯度/质量文件 产品仅供科研

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全球学术期刊中引用的产品

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Sertraline HCl/盐酸舍曲林 生物活性

靶点

  • 5-HT

    5-HT, Ki:13 nM
描述 Sertraline hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class[3]. Sertraline (10 mg/kg) is shown to produce the optimal anti-depression effectsin chronic unpredictable mild stress (CUMS)-exposed mice[4]. Male and female Wistar adult rats were subjected to the FST and sertraline was used as an antidepressant in two doses (10 mg/kg and 40 mg/kg, 3 injections in 24 h). Sertraline at both doses enhanced swimming in both sexes, but females appeared more responsive to lower sertraline doses regarding immobility levels[5]. Milnacipran (30 mg/kg) and sertraline (50 mg/kg) produced statistically significant analgesic effect compared to their control values after acute and chronic application in tail-flick test. The analgesic effects of both milnacipran (30 mg/kg) and sertraline (50 mg/kg) in the presence of L-NAME (10 mg/kg), naloxone (5 mg/kg), ondansetron (0.1 mg/kg) and prazosin (1 mg/kg) were inhibited in tail-flick test[6]. Sertraline dose-dependently increased the locomotor stimulating effect of amphetamine. At the highest dose, 20 mg/kg sertraline had a biphasic effect on amphetamine-induced hyperactivity, producing an initial reduction in amphetamine-induced hyperactivity that was later followed by an augmentation of amphetamine-induced hyperactivity in the last hour of the 3-h test[7].

Sertraline HCl/盐酸舍曲林 细胞实验

Cell Line
Concentration Treated Time Description References
Human HepG2 10 μM 18 h Sertraline significantly reduces TAG content in HepG2 cells. J Lipid Res. 2025 Jan;66(1):100711.
Human melanoma(MeWo)cells 0.01, 0.1, 1 μM 24, 48, 72 h Sertraline decreased the viability of MeWo melanoma cells in a time- and concentration-dependent manner Br J Cancer. 2017 Aug 22;117(5):656-665.
Human melanoma(A2058)cells 0.01, 0.1, 1 μM 24, 48, 72 h Sertraline decreased the viability of A2058 melanoma cells in a time- and concentration-dependent manner Br J Cancer. 2017 Aug 22;117(5):656-665.
B16-F10 0.01, 0.1, 1 μM 24, 48, 72 h Sertraline reduced the number of colonies to 76% (0.1mM), 48% (1 mM), and 32% (5 mM), when compared with the control Br J Cancer. 2017 Aug 22;117(5):656-665.
4T1 murine breast cancer cells 20–50 µM 24 h Sertraline significantly inhibited 4T1 cell proliferation at 20–50 µM, while citalopram had no significant effect Int J Mol Sci. 2022 Feb 28;23(5):2711.
Murine splenocytes 5–10 µM 48 h Sertraline significantly inhibited murine splenocyte viability at 5–10 µM, while citalopram had no significant effect Int J Mol Sci. 2022 Feb 28;23(5):2711.
HepG2 cells 10 μM 48 h To evaluate the morphological changes induced by drug-induced phospholipidosis (PL), results showed the presence of microvesicular vacuoles in the cytoplasm. Int J Mol Sci. 2020 Apr 23;21(8):2982.
HepG2 cells 20 μM 48 h To evaluate the impact of drug-induced phospholipidosis (PL) on cell viability, results showed obvious cell death in HepG2 cells. Int J Mol Sci. 2020 Apr 23;21(8):2982.
E. coli K-12 strain MG1655 0.1, 1, 10, 50 mg/L 60 days To test whether antidepressants induce bacterial resistance toward antibiotics, the results showed that Sertraline at 50 mg/L significantly increased the proportion of resistant cells to chloramphenicol, tetracycline, ciprofloxacin, and amoxicillin Proc Natl Acad Sci U S A. 2023 Jan 31;120(5):e2208344120.
GBM 2012.2 cells 3 µM 48 h To evaluate the effect of Sertraline on mitochondrial function in GBM 2012.2 cells, results showed that Sertraline significantly reduced the oxygen consumption rate (OCR) and ATP production Oncogenesis. 2024 Nov 13;13(1):39.
GBM 1919 cells 5 µM 48 h To evaluate the effect of Sertraline on the proliferation of GBM 1919 cells, results showed that Sertraline significantly reduced the proliferative capacity of the cells Oncogenesis. 2024 Nov 13;13(1):39.
Saccharomyces cerevisiae 85 μM 20 min Sertraline inhibits Pah1 PAP activity by a noncompetitive mechanism affecting the Vmax of the reaction. J Lipid Res. 2025 Jan;66(1):100711.

Sertraline HCl/盐酸舍曲林 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
BALB/cJ male mice Mouse Forced Swim Test Intraperitoneal injection 20 mg/kg Single administration To evaluate the antidepressant effects of Sertraline in the mouse forced swim test, results showed that Sertraline significantly reduced the immobility time of mice. J Med Chem. 2013 Jul 11;56(13):5495-504
Mice Forced swim test Intraperitoneal injection 20 mg/kg Single administration To evaluate antidepressant effects, results showed a significant decrease in immobility time in mice Eur J Med Chem. 2016 Nov 29;124:689-697
Mice Trp53–/– mice Oral 30 mg/kg 5 days a week, continued until the end of the experiment To evaluate the effect of Sertraline on tumorigenesis in Trp53–/– mice, the results showed that Sertraline significantly prolonged the survival of the mice. EMBO Rep. 2024 Apr;25(4):1962-1986
C57BL/6 mice B16-F10 melanoma model Intraperitoneal 10 mg/kg Daily for 12 days Sertraline (10 mg kg/C01) inhibited tumour growth by 84.4% Br J Cancer. 2017 Aug 22;117(5):656-665.
Balb/c mice 4T1 breast cancer grafted model Intraperitoneal injection 10 mg/kg Once daily for 32 days Sertraline accelerated 4T1 tumor growth in vivo, while citalopram had no significant effect Int J Mol Sci. 2022 Feb 28;23(5):2711.
Mice Forced Swim Test Intraperitoneal injection 20 mg/kg Single dose, 6 minutes To evaluate the antidepressant effect of Sertraline, the results showed that Sertraline significantly reduced the immobility time of mice. J Med Chem. 2012 Nov 26;55(22):9998-10009

Sertraline HCl/盐酸舍曲林 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01302080 - Active, not recruiting October 1, 2020 -
NCT00508859 Depression Phase 4 Completed - Canada, British Columbia ... 展开 >> UBC Vancouver, British Columbia, Canada Canada, Nova Scotia Dalhousie University Halifax, Nova Scotia, Canada, B3K 6R8 收起 <<
NCT01703039 Major Depressive Disorder Phase 2 Recruiting September 2019 United States, Massachusetts ... 展开 >> Brigham and Women's Hospital Recruiting Boston, Massachusetts, United States, 02115 Contact: Molly O'Reilly, MA       RAPID@PARTNERS.ORG    Contact: David Wolfe, MD       DWOLFE@PARTNERS.ORG    Principal Investigator: David J Wolfe, MD, MPH 收起 <<

Sertraline HCl/盐酸舍曲林 参考文献

[1]Murdoch D, McTavish D. Sertraline. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depression and obsessive-compulsive disorder. Drugs. 1992 Oct;44(4):604-24.

[2]Koe BK. Preclinical pharmacology of sertraline: a potent and specific inhibitor of serotonin reuptake. J Clin Psychiatry. 1990 Dec;51 Suppl B:13-7.

[3]Murdoch D, McTavish D. Sertraline. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depression and obsessive-compulsive disorder. Drugs. 1992 Oct;44(4):604-24

[4]Xu X, Zeng XY, Cui YX, Li YB, Cheng JH, Zhao XD, Xu GH, Ma J, Piao HN, Jin X, Piao LX. Antidepressive Effect of Arctiin by Attenuating Neuroinflammation via HMGB1/TLR4- and TNF-α/TNFR1-Mediated NF-κB Activation. ACS Chem Neurosci. 2020 Aug 5;11(15):2214-2230

[5]Kokras N, Antoniou K, Mikail HG, Kafetzopoulos V, Papadopoulou-Daifoti Z, Dalla C. Forced swim test: What about females? Neuropharmacology. 2015 Dec;99:408-21

[6]Kesim M, Yanik MN, Kadioglu M, Pepeoglu D, Erkoseoglu I, Kalyoncu NI, Yaris E. The evaluation of analgesic effects of milnacipran and sertraline in tail-flick test. Bratisl Lek Listy. 2014;115(1):3-6

[7]Sills TL, Greenshaw AJ, Baker GB, Fletcher PJ. The potentiating effect of sertraline and fluoxetine on amphetamine-induced locomotor activity is not mediated by serotonin. Psychopharmacology (Berl). 1999 Apr;143(4):426-32

Sertraline HCl/盐酸舍曲林 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.92mL

0.58mL

0.29mL

14.59mL

2.92mL

1.46mL

29.18mL

5.84mL

2.92mL

Sertraline HCl/盐酸舍曲林 技术信息

CAS号79559-97-0
分子式C17H18Cl3N
分子量 342.69
SMILES Code CN[C@H]1CC[C@H](C2=CC=CC=C21)C3=CC(Cl)=C(Cl)C=C3.[H]Cl
MDL No. MFCD00895772
别名 Sertraline (hydrochloride); CP-51974-1 HCl; CP 51,974-1; Sertraline hydrochloride
运输蓝冰
InChI Key BLFQGGGGFNSJKA-XHXSRVRCSA-N
Pubchem ID 63009
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Inert atmosphere, store in freezer, under -20°C
溶解方案

DMSO: 50 mg/mL(145.9 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 2.5 mg/mL(7.3 mM)，配合低频超声，并水浴加热至45℃助溶

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一
方案 二
方案 三

Tags: Sertraline | 79559-97-0 | Serotonin Transporter | 5-HTT | Neuronal Signaling | Serotonin Transporter | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Sertraline HCl/盐酸舍曲林 纯度/质量文件 | Sertraline HCl/盐酸舍曲林 生物活性 | Sertraline HCl/盐酸舍曲林 临床数据 | Sertraline HCl/盐酸舍曲林 参考文献 | Sertraline HCl/盐酸舍曲林 实验方案 | Sertraline HCl/盐酸舍曲林 技术信息

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