There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Sarpogrelate Hydrochloride is a highly selective serotonin (5-hydroxytryptamine, 5-HT2A) receptor antagonist used as an antiplatelet agent for the treatment of peripheral artery disease. Sarpogrelate hydrochloride might be a weak inhibitor of CYP (cytochrome P450 ) 2D6[3]. Moreover, Sarpogrelate Hydrochloride ameliorates diabetic nephropathy not only by suppressing macrophage infiltration, but also by anti-inflammatory and anti-fibrotic effects[4]. A 5- or 1-day treatment with 50 mg/kg sarpogrelate can completely protect the retina of BALB/c mice from light-induced retinopathy[5].
Sarpogrelate HCl/盐酸沙格雷酯 细胞实验
Cell Line
Concentration
Treated Time
Description
References
MDCK-II-BCRP cells
0.2, 1, 10 µM
1 hour
Evaluate the inhibitory effects of Sarpogrelate and M-1 on BCRP-mediated prazosin transport, showing no significant inhibition
Drug Des Devel Ther. 2016 Sep 14;10:2959-2972
MDCK-II-P-gp cells
0.2, 1, 10 µM
1 hour
Evaluate the inhibitory effects of Sarpogrelate and M-1 on P-gp-mediated loperamide transport, showing <10% inhibition
Drug Des Devel Ther. 2016 Sep 14;10:2959-2972
Cardiomyocytes
1 µM
48 hours
Suppressed cardiomyocyte hypertrophy induced by PE, Ang II, and ET-1
Pharmaceuticals (Basel). 2021 Dec 5;14(12):1268
Sarpogrelate HCl/盐酸沙格雷酯 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Albino BALBc/J mice
Light-induced retinopathy model
Intraperitoneal injection
25 mg/kg
Single dose, lasting 1 hour
To investigate the neuroprotective effects and mechanisms of Sarpogrelate in a light-induced retinopathy model. Results showed that Sarpogrelate exerts neuroprotection through transient activation of the MAPK/ERK pathway and sustained activation of CREB, leading to transcription of anti-apoptotic genes Bcl2, Xiap, and Ucp3.
Invest Ophthalmol Vis Sci. 2018 Jan 1;59(1):462-471
C57BL/6J male mice
Transverse aortic constriction (TAC) surgery-induced heart failure model
Oral
5 mg/kg
Once daily for 8 weeks
Suppressed TAC-induced cardiac hypertrophy and systolic dysfunction
Pharmaceuticals (Basel). 2021 Dec 5;14(12):1268
New Zealand white rabbits
High cholesterol diet-induced atherosclerosis model
Oral
5 mg/kg/day
Once daily for 90 days
To investigate the effects of SP on high cholesterol diet-induced atherosclerosis. Results showed that SP reduced plasma cholesterol and triglyceride levels, decreased oxidative stress and blood viscosity, and inhibited the formation of atherosclerotic plaques.
J Cell Mol Med. 2012 Oct;16(10):2394-400
BALB/c mice
Light-induced retinopathy model
Intraperitoneal injection
5, 15, 30, 40, 50 mg/kg
48, 24, and 0 hours before and 24 and 48 hours after exposure
To evaluate the protective effect of sarpogrelate on light-induced retinopathy. Results showed that a 50 mg/kg dose completely protected retinal morphology and function.
搜索
HazMat Fee +
