There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Sulpiride is a substituted benzamide with selective dopaminergic blocking activity. Sulpiride was selective for dopamine (D)2 receptors and also blocks D3 and D4 receptors. Sulpiride does not block D1, adrenergic, cholinergic, gamma-aminobutyric acid-ergic, histaminergic, or serotonergic receptors to an appreciable extent. The oral bioavailability of sulpiride is poor, with estimates approximating 35%. Sulpiride may cause extrapyramidal effects, autonomic effects, tardive dyskinesia, and the neuroleptic malignant syndrome[3]. At low dosages (50 to 150 mg/day), sulpiride produces a disinhibiting and antidepressant effect, which is probably related to its action on D2 presynaptic autoreceptors, thus facilitating dopaminergic neurotransmission[4]. Sulpiride and melatonin reduce tinnitus perception, decreasing dopamine activity[5]. Sulpiride attenuated by 36% the anorexia produced by intrahypothalamic injections of amphetamine[6].
Sulpiride/舒必利 细胞实验
Cell Line
Concentration
Treated Time
Description
References
HCMEC/D3 cells
1, 5, 25 µM
2 minutes
To study the transport of Sulpiride in brain microvascular endothelial cells, results showed a carrier-mediated uptake mechanism
AAPS J. 2014 Nov;16(6):1247-58.
MDA-MB-231 cells
50 µM
48 hours
To evaluate the effect of sulpiride and dexamethasone combination on colony formation, results showed the combination significantly inhibited colony formation
Acta Pharmacol Sin. 2017 Sep;38(9):1282-1296.
4T1 cells
50 µM
48 hours
To evaluate the effect of sulpiride and dexamethasone combination on colony formation, results showed the combination significantly inhibited colony formation
Acta Pharmacol Sin. 2017 Sep;38(9):1282-1296.
Sulpiride/舒必利 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Rats
MAM-E17 schizophrenia model rats
Bilateral microinjection into the ventral pallidum
0.1 μg, 1.0 μg, 4.0 μg
Single administration
To investigate the effects of sulpiride on locomotor activity and conditioned place preference in MAM-E17 rats. The results showed that larger doses of sulpiride reduced locomotor activity and restored habituation disturbance in MAM-E17 animals. Additionally, the largest dose of sulpiride induced CPP in SAL-E17 animals but not in MAM-E17 animals.
Sci Rep. 2024 May 29;14(1):12305
Wistar rats
Ventral pallidum microinjection model
Bilateral ventral pallidum microinjection
0.1 μg, 1.0 μg, and 4.0 μg per side
Single injection followed by behavioral observation
To investigate the effects of sulpiride on spatial learning and conditioned place preference. Results showed that intra-VP sulpiride dose-dependently impairs learning processes, but the largest dose induces place preference.
Sci Rep. 2022 Nov 10;12(1):19247
Zebrafish
Cocaine-induced conditioned place preference model
Water exposure
10 μM
45 minutes exposure followed by behavioral testing
To investigate the effect of sulpiride on cocaine-induced conditioned place preference. Results showed that sulpiride completely blocked cocaine-induced CPP.
Pharmacol Biochem Behav. 2012 Dec;103(2):157-67
Sprague-Dawley rats
Healthy rats
Oral
15 mg/kg
Single dose
To evaluate the pharmacokinetic parameters of sulpiride lipospheres, showing a 3.4-fold improvement in oral bioavailability
Int J Nanomedicine. 2021 Mar 9;16:2013-2044
Zebrafish (AB strain)
Zebrafish
Water exposure
20 ng/L, 50 ng/L, 100 ng/L
Half of the water replaced daily for 14 days
To investigate the effects of sulpiride and clozapine on dopaminergic (DAergic) and serotonergic (5-HTergic) neurotransmitter systems in the brain of zebrafish. Results showed that sulpiride and clozapine interfered with DAergic and 5-HTergic neurotransmitter systems in the telencephalon and diencephalon of zebrafish, leading to abnormal mRNA and protein levels of key functional molecules in DA and 5-HT signaling pathways.
Sci Rep. 2022 Oct 26;12(1):17973
Nude mice
Human breast cancer MCF-7/Adr xenograft model
Oral
25 or 50 mg/kg
Daily administration
SUL significantly enhanced the inhibitory effect of DEX on the growth of drug-resistant breast cancer by antagonizing D2DR, indicating the involvement of a CSC-related mechanism
Acta Pharmacol Sin. 2019 Dec;40(12):1596-1602
C57BL/6J mice
Brain slice model
Recirculating perfusion
5 μM
Single 50 ms flash
Block D2 receptors and measure dopamine dissociation rates
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