Ambeed 大中华区 CN | ZH

中文 - ZH English - EN

Ambeed.cn

搜索

关键字搜索批量搜索

首页 收藏 购物车0
首页 /
抑制剂/激动剂
天然产物 肿瘤
/
DNA损伤
细胞周期 毛茛科 结构分类 肿瘤表观遗传和基因调控
/
拓扑异构酶
生物碱 黄连属
/ Groenlandicine/格兰地新

Groenlandicine/格兰地新 {[allProObj[0].p_purity_real_show]}

货号：A159412

Groenlandicine是从黄连中分离得到的一种原小檗碱生物碱，具有中度抑制人类重组醛糖还原酶 (HRAR) 的作用，IC50值为154.2 μM，并能诱导拓扑异构酶I介导的DNA裂解。

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Groenlandicine/格兰地新 化学结构 CAS号：38691-95-1
Groenlandicine/格兰地新 化学结构
CAS号：38691-95-1
Groenlandicine/格兰地新 3D分子结构
CAS号：38691-95-1
Groenlandicine/格兰地新 化学结构 CAS号：38691-95-1
Groenlandicine/格兰地新 3D分子结构 CAS号：38691-95-1
规格 价格 会员价 库存 数量
{[ item.pr_size ]}

{[ getRatePriceInt(item.pr_rmb, 1,1) ]}

{[ getRatePriceInt(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_tag_price, item.pr_am) ]}

{[ getRatePriceInt(item.pr_rmb, 1,1) ]}

{[ getRatePriceInt(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_tag_price, item.pr_am) ]} 		{[ getRatePriceInt(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_tag_price, item.pr_am) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1,item.mem_isinteger) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate,item.mem_isinteger) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate,item.mem_isinteger) ]} 现货 1周 咨询 - +
购物车0 收藏 询单

Groenlandicine/格兰地新 纯度/质量文件 产品仅供科研

货号：A159412 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]
• Cell, 2025. Ambeed. [ A122167 ]
• Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]
• Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]
• Nat. Nanotechnol., 2025. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]
更多 >
产品名称 Topo I ↓ Topo II ↓ Topo IV ↓ Topoisomerase ↓ 其他靶点 纯度
Ellagic acid ✔ 98%
β-Lapachone ✔ 99%+
(s)-10-hydroxycamptothecin ✔ 98+%
Camptothecin ++

Topo I, IC50: 0.68 μM

 		98%
Betulinic acid ++

Eukaryotic topoisomerase I, IC50: 5 μM

 		98%
Topotecan ++++

Topo I (DU-145 Luc cells), IC50: 2 nM

Topo I (MCF-7 Luc cells), IC50: 13 nM

 		98%
Irinotecan HCl Trihydrate ✔ 98%
SN-38 ✔ 98%
Levofloxacin hydrate ✔ 98%
Dexrazoxane ✔ 99%+
Ofloxacin ✔ 98+%
Enoxacin ✔ 99%+
Flumequine +

Topo II, IC50: 15 μM

 		98%
Levofloxacin ✔ 97%
Etoposide ✔ 98%
Pefloxacin mesylate dihydrate ✔ 99.5%
Marbofloxacin ✔ 98+%
Voreloxin HCl ✔ 98%
Mitoxantrone 2HCl ✔ PKC 98%
Nalidixic acid ✔ 98%
Doxorubicin ✔ 97%
Novobiocin sodium ✔ 95%
Amonafide ✔ 99%+
Pirarubicin ✔ 98%+
Idarubicin HCl +++

Topo II (MCF-7 cells), IC50: 3.3 ng/mL

 		99%+
Genistein ✔ EGFR 98%
Teniposide ✔ 98%
Moxifloxacin ✔ 98%
Ciprofloxacin ✔ 98%
Clinafloxacin ✔ 99%
Gatifloxacin ✔ 98%
Daunorubicin HCl +++

DNA synthesis, Ki: 20 nM

 		98%
Epirubicin HCl ✔ 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Groenlandicine/格兰地新 细胞实验

Cell Line
Concentration Treated Time Description References
MG63 0, 0.05, 0.1, 0.25, 0.5, 1, and 2 μM 24 hours Groenlandicine inhibited the proliferation and promoted apoptosis of MG63 cells by down-regulating TOP1 protein expression. J Bone Oncol. 2024 Aug 24;48:100631
SJSA-1 0, 0.05, 0.1, 0.25, 0.5, 1, and 2 μM 24 hours Groenlandicine inhibited the proliferation and promoted apoptosis of SJSA-1 cells by down-regulating TOP1 protein expression. J Bone Oncol. 2024 Aug 24;48:100631

Groenlandicine/格兰地新 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
BALB/c-nu mice Subcutaneous tumor model Intraperitoneal injection 1.5 mg/kg groenlandicine and 0.5 mg/kg cisplatin Every 3 days for 18 days Groenlandicine combined with cisplatin significantly suppressed tumor growth and reduced nephrotoxicity. J Bone Oncol. 2024 Aug 24;48:100631

Groenlandicine/格兰地新 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.10mL

0.62mL

0.31mL

15.51mL

3.10mL

1.55mL

31.02mL

6.20mL

3.10mL

Groenlandicine/格兰地新 技术信息

CAS号38691-95-1
分子式C19H16NO4
分子量 322.33
SMILES Code COC1=CC2=C(C=C1O)CC[N+]3=C2C=C4C=CC5=C(OCO5)C4=C3
MDL No. MFCD22586442
别名
运输蓝冰
InChI Key PGIOBGCIEGZHJH-UHFFFAOYSA-O
Pubchem ID 3084708
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Keep in dark place, sealed in dry, 2-8°C
溶解方案

DMSO: 1 mg/mL(3.1 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

Tags: Groenlandicine | 38691-95-1 | Topoisomerase Agonist | Cell Cycle/DNA Damage | Topoisomerase | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Groenlandicine/格兰地新 纯度/质量文件 | Groenlandicine/格兰地新 亚型比较 | Groenlandicine/格兰地新 实验方案 | Groenlandicine/格兰地新 技术信息

AmBeed 相关网站 AmBeed.cn AmBeed.com
AmBeed
关于我们
联系我们
资讯中心
网站地图
产品手册
  • 批次文件查询
    • 客户支持
    技术支持
    专业术语
    缩略词释义
    质量手册
    产品咨询
    计算器
    活动政策
    订购方法
    积分商城
    活动声明
    联系我们
    400-920-2911 sales@ambeed.cn tech@ambeed.cn
    AmBeed 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质用途提供服务。

    尊敬的 AmBeed 客户您好，
    请您选择所在区域，我们将转接对应客服为您服务！

    热门区域

    A

    B

    C

    F

    G

    H

    J

    L

    N

    Q

    S

    T

    X

    Y

    Z

    热 A B C F G H J L N Q S T X Y Z