Banoxantrone dihydrochloride是一种新型生物还原剂，可以还原为稳定的 DNA 亲和化合物 AQ4。AQ4 是一种有效的拓扑异构酶 II 抑制剂。
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Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Evaluate the loading efficiency and subsequent release capability of AQ4N in M1 macrophages
Signal Transduct Target Ther. 2022 Mar 16;7(1):74
Banoxantrone 2HCl 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Mice
T50/80 mammary carcinoma model
Intraperitoneal injection
50–100 mg/kg
Single dose
To evaluate the ability of AQ4N to potentiate the anti-tumour effect of cisplatin, results showed that AQ4N significantly enhanced the anti-tumour effect of cisplatin
Br J Cancer. 2001 Aug 17;85(4):625-9
B6D2F1 mice
T50/80 mammary carcinoma model
Intraperitoneal injection
20-320 mg/kg (oxic), 3-130 mg/kg (hypoxic)
Single dose
To evaluate the anti-tumour effect of AQ4N under hypoxic conditions, showing a dose enhancement ratio (DER) of 5.1, indicating reduction to AQ4 in vivo and enhanced anti-tumour toxicity.
Br J Cancer. 1995 Jul;72(1):76-81
Mice
MAC16, MAC26, RIF-1, NT and SCCVII tumor models
Intraperitoneal injection
200–250 mg/kg
Single dose
To evaluate the anti-tumor effects of AQ4N as a single agent or in combination with radiotherapy and chemotherapy. Results showed that AQ4N was effective as a single agent in MAC16 tumors, and significantly enhanced anti-tumor effects when combined with radiotherapy or chemotherapy in other tumor models.
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