Sophocarpine monohydrate | 槐果碱 | Autophagy Activator

Sophocarpine monohydrate/槐果碱水合物 {[allProObj[0].p_purity_real_show]}

货号：A586664 同义名： 槐果碱

Sophocarpine monohydrate 是从Sophora alopecuroides L.中分离并纯化的一种天然产物，具有抗病毒、抗恶病质和抗炎作用。它主要通过抑制TLR4途径来缓解肝纤维化。此外，Sophocarpine还可以减轻由短暂性局部脑缺血引起的脑缺血损伤，这种神经保护作用可能与Sophocarpine的抗ASIC1通道和抗凋亡作用有关。

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

Sophocarpine monohydrate/槐果碱水合物化学结构
CAS号：145572-44-7

Sophocarpine monohydrate/槐果碱水合物 3D分子结构
CAS号：145572-44-7

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Akt 亚型比较

PI3K 亚型比较

自噬亚型比较

产品名称	Akt ↓ ↑	Akt1 ↓ ↑	Akt2 ↓ ↑	Akt3 ↓ ↑	其他靶点	纯度
Honokiol	✔				MEK	98%
PF-04691502	++++ P-Akt (S473), IC50: 3.8 nM P-Akt (T308), IC50: 7.5 nM					98+%
PHT-427	+ Akt, Ki: 2.7 μM					99%+
Deguelin	✔				PI3K	99%+
TIC10 isomer	✔				ERK	98+%
Perifosine	+ Akt, IC50: 4.7 μM					98%
Miltefosine	✔				PKC,PI3K	98%
Triciribine	+ Akt, IC50: 130 nM					99%+
Uprosertib		+ Akt1, IC50: 180 nM	+ Akt2, IC50: 328 nM	++ Akt3, IC50: 38 nM		99%+
Afuresertib		++++ Akt1, Ki: 0.08 nM	++++ Akt2, Ki: 2 nM	++++ Akt3, Ki: 2.6 nM		99%+
Miransertib		++++ Akt1, IC50: 5 nM	++++ Akt2, IC50: 4.5 nM	++ Akt3, IC50: 16 nM		98+%
GSK-690693		++++ Akt1, IC50: 2 nM	+++ Akt2, IC50: 13 nM	+++ Akt3, IC50: 9 nM		99%+
AT7867		++ Akt1, IC50: 32 nM	++ Akt2, IC50: 17 nM	++ Akt3, IC50: 47 nM	PKA	99%+
AKT inhibitor VIII		++ Akt1, IC50: 58 nM	+ Akt2, IC50: 210 nM	+ Akt3, IC50: 2119 nM		97%
MK-2206 2HCl		+++ Akt1, IC50: 8 nM	+++ Akt2, IC50: 12 nM	+ Akt3, IC50: 65 nM		99%+
Ipatasertib		++++ Akt1, IC50: 5 nM	++ Akt2, IC50: 18 nM	+++ Akt3, IC50: 8 nM		99%+
AT13148		++ Akt1, IC50: 38 nM	+ Akt2, IC50: 402 nM	++ Akt3, IC50: 50 nM	PKA	95%
Capivasertib		++++ Akt1, IC50: 3 nM	+++ Akt2, IC50: 8 nM	+++ Akt3, IC50: 8 nM		99%+
A-674563 HCl		+++ Akt1, Ki: 11 nM			PKA	99%
CCT128930			+++ Akt2, IC50: 6 nM		PKA	95%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

产品名称	C2β ↓ ↑	p110α ↓ ↑	p110β ↓ ↑	p110γ ↓ ↑	p110δ ↓ ↑	PI3K ↓ ↑	Vps34 ↓ ↑	其他靶点	纯度
A66	+ C2β, IC50: 462 nM	++ p110α, IC50: 32 nM							99%+
Taselisib	+ C2β, IC50: 292 nM	++++ PI3Kα, Ki: 0.29 nM	+++ PI3Kβ, Ki: 9.1 nM	++++ PI3Kγ, Ki: 0.97 nM	++++ PI3Kδ, Ki: 0.12 nM		+ hVps34, IC50: 374 nM		99%+
Gedatolisib		++++ PI3Kα, IC50: 0.4 nM		+++ PI3Kγ, IC50: 5.4 nM				mTOR	99%
HS-173		++++ PI3Kα , IC50: 0.8 nM							99%+
Serabelisib		+++ PI3Kα, IC50: 21 nM							99%+
GNE-477		++++ PI3Kα, IC50: 4 nM						mTOR	99%
YM-201636		+ p110α, IC50: 3.3 μM						PIKfyve	98%
AS-252424		+ PI3Kα, IC50: 935 nM		++ PI3Kγ, IC50: 33 nM					99%
Alpelisib		+++ PI3Kα, IC50: 5 nM							99%+
AS-604850		+ PI3Kα, IC50: 4.5 μM		+ PI3Kγ, IC50: 0.25 μM					99%
SF2523		++ PI3Kα, IC50: 34 nM		++ PI3Kγ, IC50: 158 nM				DNA-PK,mTOR	99%+
Inavolisib		++++ PI3K alpha, IC50: 0.038 nM							99%+
Bimiralisib		++++ PI3Kα, Kd: 1.5 nM	+++ PI3Kβ, Kd: 11 nM	++ PI3Kγ, Kd: 25 nM	++ PI3Kδ, Kd: 25 nM			mTOR	99%+
GSK1059615		++++ PI3Kα, IC50: 0.4 nM	++++ PI3Kβ, IC50: 0.6 nM	+++ PI3Kγ, IC50: 5 nM	++++ PI3Kδ, IC50: 2 nM			mTOR	98%
GSK2636771			✔						99%
Fimepinostat		+++ PI3Kα, IC50: 19 nM	++ PI3Kβ, IC50: 54 nM		++ PI3Kδ, IC50: 39 nM				99%+
VS-5584		++++ PI3Kα, IC50: 2.6 nM	+++ PI3Kβ, IC50: 21 nM	++++ PI3Kγ, IC50: 3.0 nM	++++ PI3Kδ, IC50: 2.7 nM			mTOR	98%
Dactolisib		++++ p110α1, IC50: 4 nM	++ p110β, IC50: 75 nM	+++ p110γ, IC50: 5 nM	+++ p110δ, IC50: 7 nM				98+%
PI-103		++++ p110α, IC50: 2 nM	++++ p110β, IC50: 3 nM	+++ p110γ, IC50: 15 nM	++++ p110δ, IC50: 3 nM			DNA-PK,mTOR	99%+
PI-3065			+ p110β, IC50: 1078 nM		+++ p110δ, IC50: 15 nM				99%+
Voxtalisib		++ PI3Kα, IC50: 39 nM	++ PI3Kβ, IC50: 113 nM	+++ PI3Kγ, IC50: 9 nM	++ PI3Kδ, IC50: 43 nM			DNA-PK,mTOR	99%+
AZD-8835		+++ PI3Kα, IC50: 6.2 nM	+ PI3Kβ, IC50: 431 nM	++ PI3Kγ, IC50: 90 nM	+++ PI3Kδ, IC50: 5.7 nM				99%
Pilaralisib analogue		++ PI3Kα, IC50: 39 nM	++ PI3Kβ, IC50: 36 nM	+++ PI3Kγ, IC50: 23 nM	++ PI3Kδ, IC50: 36 nM				99%+
ZSTK474		+++ PI3Kα, IC50: 16 nM	++ PI3Kβ, IC50: 44 nM	++ PI3Kγ, IC50: 49 nM	+++ PI3Kδ, IC50: 4.6 nM	++ PI3K, IC50: 37 nM			98%
AS-605240		++ PI3Kα, IC50: 60 nM	+ PI3Kβ, IC50: 270 nM	+++ PI3Kγ, IC50: 8 nM	+ PI3Kδ, IC50: 300 nM				98%
TGX-221			+++ p110β, IC50: 5 nM		++ p110δ, IC50: 0.1 μM				99%+
PF-04691502		++++ PI3Kα, Ki: 1.8 nM	++++ PI3Kβ, Ki: 2.1 nM	++++ PI3Kγ, Ki: 1.9 nM	++++ PI3Kδ, Ki: 1.6 nM			mTOR	98+%
GDC-0084		++++ PI3Kα, Ki app: 2 nM	++ PI3Kβ, Ki app: 46 nM	+++ PI3Kγ, Ki app: 10 nM	++++ PI3Kδ, Ki app: 3 nM			mTOR	99%+
Buparlisib		++ p110α, IC50: 52 nM	+ p110β, IC50: 166 nM	+ p110γ, IC50: 262 nM	++ p110δ, IC50: 116 nM		+ Vps34, IC50: 2.4 μM	mTOR	98%
LY294002		+ p110α, IC50: 0.5 μM	+ p110β, IC50: 0.97 μM		+ p110δ, IC50: 0.57 μM			DNA-PK	99%+
AZD 6482		+ PI3Kα, IC50: 870 nM	+++ PI3Kβ, IC50: 10 nM		++ PI3Kδ, IC50: 80 nM			DNA-PK	99%+
Pictilisib		++++ p110α, IC50: 3 nM	++ p110β, IC50: 33 nM	++ p110γ, IC50: 75 nM	++++ p110δ, IC50: 3 nM			mTOR	99%+
PKI-402		++++ PI3Kα, IC50: 2 nM	+++ PI3Kβ, IC50: 7 nM	+++ PI3Kγ, IC50: 16 nM	+++ PI3Kδ, IC50: 14 nM			mTOR	98%
Copanlisib		++++ PI3Kα, IC50: 0.5 nM	++++ PI3Kβ, IC50: 3.7 nM	+++ PI3Kγ, IC50: 6.4 nM	++++ PI3Kδ, IC50: 0.7 nM				99%+
Omipalisib		++++ p110α, Ki: 0.019 nM	++++ p110β, Ki: 0.13 nM	++++ p110γ, Ki: 0.06 nM	++++ p110δ, Ki: 0.024 nM				99%+
Izorlisib		+++ PI3Kα, IC50: 14 nM	++ PI3Kβ, IC50: 0.12 μM	++ PI3Kγ, IC50: 36 nM	+ PI3Kδ, IC50: 0.50 μM				99%+
AZD8186		++ PI3Kα, IC50: 35 nM	++++ PI3Kβ, IC50: 4 nM		+++ PI3Kδ, IC50: 12 nM				99%
KU-0060648		++++ PI3Kα, IC50: 4 nM	++++ PI3Kβ, IC50: 0.5 nM	+ PI3Kγ, IC50: 0.59 μM	++++ PI3Kδ, IC50: 0.1 nM			DNA-PK	98%
Apitolisib		+++ p110α, IC50: 5 nM	++ p110β, IC50: 27 nM	+++ p110γ, IC50: 14 nM	+++ p110δ, IC50: 7 nM			mTOR	98%+
CZC24832			+ PI3Kβ, IC50: 1.1 μM	++ PI3Kγ, IC50: 27 nM					98+%
BGT226 maleate		++++ PI3Kα, IC50: 4 nM	++ PI3Kβ, IC50: 63 nM	++ PI3Kγ, IC50: 38 nM				mTOR	99%+
TG 100713		++ PI3Kα, IC50: 165 nM	+ PI3Kβ, IC50: 215 nM	++ PI3Kγ, IC50: 50 nM	+++ PI3Kδ, IC50: 24 nM				98%+
PI3K-IN-1		++ PI3Kα, IC50: 39 nM	++ PI3Kβ, IC50: 113 nM	+++ PI3Kγ, IC50: 9 nM	++ PI3Kδ, IC50: 43 nM			DNA-PK,mTOR	98+%
TG100-115		+ PI3Kα, IC50: 1.3 μM	+ PI3Kβ, IC50: 1.2 μM	++ PI3Kγ, IC50: 83 nM	+ PI3Kδ, IC50: 235 nM				98%
PIK-90		+++ PI3Kα, IC50: 11 nM	+ PI3Kβ, IC50: 350 nM	+++ PI3Kγ, IC50: 18 nM	++ PI3Kδ, IC50: 58 nM				99%+
PIK-294			+ p110β, IC50: 490 nM	++ p110γ, IC50: 160 nM	+++ p110δ, IC50: 10 nM				99%+
Duvelisib			++++ PI3Kβ, Ki: 1564 pM	++ PI3Kγ, Ki: 243 pM	++++ PI3Kδ, Ki: 23 pM				99%+
GDC-0326		++++ PI3Kα, Ki: 0.2 nM	++ PI3Kβ, Ki: 26.6 nM	+++ PI3Kγ, Ki: 10.2 nM	++++ PI3Kδ, Ki: 4 nM				98%
Quercetin Dihydrate			+ PI3Kβ, IC50: 5.4 μM	+ PI3Kγ, IC50: 2.4 μM	+ PI3Kδ, IC50: 3.0 μM				95%
Quercetin			+ PI3Kβ, IC50: 5.4 μM	+ PI3Kγ, IC50: 2.4 μM	+ PI3Kδ, IC50: 3.0 μM			PKC,Src,Sirtuin	95%
Leniolisib		+ PI3Kα, IC50: 0.244 μM	+ PI3Kβ, IC50: 0.424 μM	+ PI3Kγ, IC50: 2.23 μM	+++ PI3Kδ, IC50: 0.011 μM			DNA-PK	99%+
PIK-108			✔						99%
Eganelisib				+++ PI3Kγ, IC50: 16 nM					99%+
CAY10505				✔					99%
IPI-3063					++++ p110δ, IC50: 2.5 nM				99%
Nemiralisib					++++ PI3Kδ, pKi: 9.9				99%+
PF-4989216		++++ p110α, IC50: 2 nM		++ p110γ, IC50: 65 nM	++++ p110δ, IC50: 1 nM				99%+
PIK-75 HCl		+++ p110α, IC50: 5.8 nM		++ p110γ, IC50: 76 nM	+ p110δ, IC50: 0.51 μM			DNA-PK	99%+
Tenalisib				++ PI3Kγ, IC50: 33.2 nM	++ PI3Kδ, IC50: 24.5 nM				98%
Acalisib					+++ p110δ, IC50: 14 nM				99%+
Umbralisib					+++ PI3Kδ, IC50: 22.2 nM				99%+
AMG319				+ PI3Kγ, IC50: 850 nM	+++ PI3Kδ, IC50: 18 nM				99%
IC-87114				+ PI3Kγ, IC50: 29 μM	+ PI3Kδ, IC50: 0.5 μM				99%+
Idelalisib				++ p110γ, IC50: 89 nM	++++ p110δ, IC50: 2.5 nM				98%
PIK-293				+ p110γ, IC50: 10 μM	+ p110δ, IC50: 0.24 μM				99%+
Vps34-PIK-III					+ PI3Kδ, IC50: 1.2μM		+++ Vps34, IC50: 0.018μM		99%+
GSK2292767					✔				98%
Seletalisib				+ PI3Kγ, IC50: 282 nM	+++ PI3Kδ, IC50: 12 nM				99%+
P110δ-IN-1					++++ P110δ, IC50: 0.6 nM				99%
PI3Kδ-IN-5					++++ PI3Kδ, IC50: 0.9 nM				99%
SRX3207		+ PI3K alpha, IC50: 244 nM		+ PI3K gamma, IC50: 9790 nM	+ PI3K delta, IC50: 388 nM			Syk	98%
Parsaclisib HCl					++++ PI3Kδ, IC50: 1 nM				98%
IHMT-PI3Kδ-372					+++ PI3Kδ, IC50: 14 nM				98%
Trigonelline						✔		Akt	99%+
Wortmannin						++++ PI3K, IC50: 3 nM		DNA-PK,MLCK	99%+
Samotolisib						✔		DNA-PK	99%+
GNE-317						✔			99%+
Oroxin B						✔		Akt,PTEN	99%+
NU 7026						+ PI3K, IC50: 13 μM		DNA-PK	98+%
Deguelin						✔		Akt	99%+
Ailanthone						✔		ATM/ATR,Akt,CDK	98%
Resibufogenin						✔		ROS	98%
KU-57788						+ PI3K, IC50: 5 μM		DNA-PK,mTOR	99%+
Cinobufagine						✔		Akt	99%
α-Linolenic acid						✔			97% (GC)
MTX-211						✔		EGFR	98%
PI3K/mTOR Inhibitor-2						++++ PI3K, IC50: 3.4 nM		mTOR	99%+
SPP-86						✔			99%+
(E)-Akt inhibitor-IV						✔			98%
Vps34-IN-1							++ Vps34, IC50: 25 nM		98%
SAR405							++++ Vps34, IC50: 1.2 nM		98+%
3-Methyladenine				+ PI3Kγ, IC50: 60 μM			+ Vps34, IC50: 25 μM	Autophagy	98%
Vps34-IN-4							+++ VPS34, IC50: 15 nM		98%+
Autophinib							+++ Vps34, IC50: 19 nM	Autophagy	99%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

产品名称	Autophagy ↓ ↑	其他靶点	纯度
SBI-0206965	+++ ULK2, IC50: 711 nM ULK1, IC50: 108 nM		95%
Hydroxychloroquine sulfate	✔		99%
Valproic acid sodium	✔	HDAC	97%
PFK-015	++ PFKFB3, IC50: 207 nM		99%+
MRT68921 HCl	++++ ULK2, IC50: 1.1 nM ULK1, IC50: 2.9 nM		99%+
ROC-325	✔		99%+
Autophinib	+++ Autophagy, IC50: 40 nM		99%
Lys05	✔		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Sophocarpine monohydrate/槐果碱水合物生物活性

描述

Sophocarpine, a natural product isolated and purified from the herb of Sophora alopecuroidos L., with anti-viral, anti-cachectic and anti-inflammatory effects, can alleviate liver fibrosis mainly by inhibiting the TLR4 pathway, it may be a potential chemotherapeutic agent for chronic liver diseases, ameliorate the ischemic injury induced by transient focal cerebral ischemia in rats and that this neuroprotective effect may be related to the anti-ASIC1 channel and anti-apoptotic action of sophocarpine, and also alleviate hepatocyte steatosis and the potential mechanism may be the activated signaling pathway of AMPK.

Sophocarpine monohydrate/槐果碱水合物细胞实验

Cell Line UM-SCC-47 cells UM-SCC-22B cells UM-SCC-47 cells UM-SCC-22B cells Bone marrow-derived macrophages (BMM) Bone marrow-derived macrophages (BMM) Neonatal rat ventricular myocytes Rabbit sinus node cells Guinea pig papillary muscle cells Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) Rat aortic endothelial cells (RAECs)	Concentration	Treated Time	Description	References
UM-SCC-47 cells	1 μM, 2 μM, 4 μM	24 hours	To evaluate the effect of Sophocarpine on miR-21 expression, results showed that Sophocarpine downregulated miR-21 expression in a dose-dependent manner.	Mol Ther. 2017 Sep 6;25(9):2129-2139.
UM-SCC-22B cells	1 μM, 2 μM, 4 μM	24 hours	To evaluate the effect of Sophocarpine on miR-21 expression, results showed that Sophocarpine downregulated miR-21 expression in a dose-dependent manner.	Mol Ther. 2017 Sep 6;25(9):2129-2139.
UM-SCC-47 cells	1.536 μM (IC50)	48 hours	To evaluate the inhibitory effect of Sophocarpine on HNSCC cell proliferation, results showed that Sophocarpine inhibited cell proliferation in a dose-dependent manner.	Mol Ther. 2017 Sep 6;25(9):2129-2139.
UM-SCC-22B cells	1.067 μM (IC50)	48 hours	To evaluate the inhibitory effect of Sophocarpine on HNSCC cell proliferation, results showed that Sophocarpine inhibited cell proliferation in a dose-dependent manner.	Mol Ther. 2017 Sep 6;25(9):2129-2139.
Bone marrow-derived macrophages (BMM)	0.25, 0.50, 1.00 mM	48 hours	Evaluate the effect of SPC on bone resorption, results showed dose-dependent reduction in bone resorption area	Br J Pharmacol. 2018 Mar;175(6):859-876.
Bone marrow-derived macrophages (BMM)	0.31-2 mM	48 or 96 hours	Evaluate the effect of SPC on BMM cell viability, results showed no cytotoxicity up to 2 mM	Br J Pharmacol. 2018 Mar;175(6):859-876.
Neonatal rat ventricular myocytes	10 μmol/L	3 minutes	To study the effects of sophocarpine on sodium current, results showed that sophocarpine significantly inhibited sodium current.	Acta Pharmacol Sin. 2011 Mar;32(3):311-20.
Rabbit sinus node cells	0.1-1 μmol/L		To study the effects of sophocarpine on slow response action potentials, results showed that sophocarpine decreased APA and Vmax and prolonged APD.	Acta Pharmacol Sin. 2011 Mar;32(3):311-20.
Guinea pig papillary muscle cells	1-100 μmol/L	8-10 minutes	To study the effects of sophocarpine on fast response action potentials, results showed that sophocarpine dose-dependently prolonged APD and ERP and decreased APA and Vmax.	Acta Pharmacol Sin. 2011 Mar;32(3):311-20.
Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)	2, 10, 50 μM	24 hours	To evaluate the effects of sophocarpine on impedance and extracellular field potential (EFP) in cardiomyocytes. Results showed that sophocarpine dose-dependently affected both impedance and EFP, related to disruption of calcium homeostasis and oxidative stress.	in human pluripotent stem cell-derived cardiomyocytes. Stem Cell Res Ther.
Rat aortic endothelial cells (RAECs)	0.0625, 0.125, 0.25, 0.5, 1.0, 2.0 mmol/L	48 hours	To evaluate the protective effects of Sophocarpine on AGEs-induced oxidative stress and apoptosis. Results showed that Sophocarpine significantly suppressed AGEs-induced ROS production and apoptosis, restored phosphorylation of MKK3/6 and p38 MAPK, and promoted Nrf2 nuclear translocation and ARE binding activity.	J Am Heart Assoc. 2017 Dec 2;6(12):e007441.

Cell Line

Concentration

Treated Time

Description

References

UM-SCC-47 cells

1 μM, 2 μM, 4 μM

24 hours

To evaluate the effect of Sophocarpine on miR-21 expression, results showed that Sophocarpine downregulated miR-21 expression in a dose-dependent manner.

Mol Ther. 2017 Sep 6;25(9):2129-2139.

UM-SCC-22B cells

1 μM, 2 μM, 4 μM

24 hours

To evaluate the effect of Sophocarpine on miR-21 expression, results showed that Sophocarpine downregulated miR-21 expression in a dose-dependent manner.

Mol Ther. 2017 Sep 6;25(9):2129-2139.

UM-SCC-47 cells

1.536 μM (IC50)

48 hours

To evaluate the inhibitory effect of Sophocarpine on HNSCC cell proliferation, results showed that Sophocarpine inhibited cell proliferation in a dose-dependent manner.

Mol Ther. 2017 Sep 6;25(9):2129-2139.

UM-SCC-22B cells

1.067 μM (IC50)

48 hours

To evaluate the inhibitory effect of Sophocarpine on HNSCC cell proliferation, results showed that Sophocarpine inhibited cell proliferation in a dose-dependent manner.

Mol Ther. 2017 Sep 6;25(9):2129-2139.

Bone marrow-derived macrophages (BMM)

0.25, 0.50, 1.00 mM

48 hours

Evaluate the effect of SPC on bone resorption, results showed dose-dependent reduction in bone resorption area

Br J Pharmacol. 2018 Mar;175(6):859-876.

Bone marrow-derived macrophages (BMM)

0.31-2 mM

48 or 96 hours

Evaluate the effect of SPC on BMM cell viability, results showed no cytotoxicity up to 2 mM

Br J Pharmacol. 2018 Mar;175(6):859-876.

Neonatal rat ventricular myocytes

10 μmol/L

3 minutes

To study the effects of sophocarpine on sodium current, results showed that sophocarpine significantly inhibited sodium current.

Acta Pharmacol Sin. 2011 Mar;32(3):311-20.

Rabbit sinus node cells

0.1-1 μmol/L

To study the effects of sophocarpine on slow response action potentials, results showed that sophocarpine decreased APA and Vmax and prolonged APD.

Acta Pharmacol Sin. 2011 Mar;32(3):311-20.

Guinea pig papillary muscle cells

1-100 μmol/L

8-10 minutes

To study the effects of sophocarpine on fast response action potentials, results showed that sophocarpine dose-dependently prolonged APD and ERP and decreased APA and Vmax.

Acta Pharmacol Sin. 2011 Mar;32(3):311-20.

Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)

2, 10, 50 μM

24 hours

To evaluate the effects of sophocarpine on impedance and extracellular field potential (EFP) in cardiomyocytes. Results showed that sophocarpine dose-dependently affected both impedance and EFP, related to disruption of calcium homeostasis and oxidative stress.

in human pluripotent stem cell-derived cardiomyocytes. Stem Cell Res Ther.

Rat aortic endothelial cells (RAECs)

0.0625, 0.125, 0.25, 0.5, 1.0, 2.0 mmol/L

48 hours

To evaluate the protective effects of Sophocarpine on AGEs-induced oxidative stress and apoptosis. Results showed that Sophocarpine significantly suppressed AGEs-induced ROS production and apoptosis, restored phosphorylation of MKK3/6 and p38 MAPK, and promoted Nrf2 nuclear translocation and ARE binding activity.

J Am Heart Assoc. 2017 Dec 2;6(12):e007441.

Sophocarpine monohydrate/槐果碱水合物动物实验

Species Nude mice Sprague-Dawley rats Guinea pigs Sprague-Dawley rats	Animal Model UM-SCC-22B xenograft model Titanium particle-induced femoral implant loosening model Isoprenaline-induced arrhythmia model AGEs-induced aortic endothelial cell injury model	Administration	Dosage	Frequency	Description	References
Nude mice	UM-SCC-22B xenograft model	Intravenous injection	5 mg/kg	Every other day for 21 days	To evaluate the inhibitory effect of Sophocarpine on tumor growth in vivo, results showed that Sophocarpine significantly inhibited tumor growth without observable tissue toxicity.	Mol Ther. 2017 Sep 6;25(9):2129-2139.
Sprague-Dawley rats	Titanium particle-induced femoral implant loosening model	Intraperitoneal injection	20 mg/kg/day	Once daily for 4 or 12 weeks	Evaluate the preventive effect of SPC on titanium particle-induced implant loosening, results showed SPC inhibited osteoclast formation, reduced pseudomembrane formation, improved bone-implant contact, and enhanced implant stability	Br J Pharmacol. 2018 Mar;175(6):859-876.
Guinea pigs	Isoprenaline-induced arrhythmia model	Perfusion	300 μmol/L	Single administration, lasting 11-17 minutes	To study the effects of sophocarpine on isoprenaline-induced arrhythmia, results showed that sophocarpine reversed arrhythmia and decreased heart rate.	Acta Pharmacol Sin. 2011 Mar;32(3):311-20.
Sprague-Dawley rats	AGEs-induced aortic endothelial cell injury model	Intraperitoneal injection	40 mg/kg/day	Once daily for 10 consecutive days	To evaluate the protective effects of Sophocarpine on AGEs-induced oxidative stress and apoptosis in aortic endothelial cells. Results showed that Sophocarpine significantly suppressed AGEs-induced ROS production and apoptosis, restored phosphorylation of MKK3/6 and p38 MAPK, and promoted Nrf2 nuclear translocation and antioxidant enzyme expression.	J Am Heart Assoc. 2017 Dec 2;6(12):e007441.

Species

Nude mice Sprague-Dawley rats Guinea pigs Sprague-Dawley rats

Animal Model

UM-SCC-22B xenograft model Titanium particle-induced femoral implant loosening model Isoprenaline-induced arrhythmia model AGEs-induced aortic endothelial cell injury model

Administration

Dosage

Frequency

Description

References

Nude mice

UM-SCC-22B xenograft model

Intravenous injection

5 mg/kg

Every other day for 21 days

To evaluate the inhibitory effect of Sophocarpine on tumor growth in vivo, results showed that Sophocarpine significantly inhibited tumor growth without observable tissue toxicity.

Mol Ther. 2017 Sep 6;25(9):2129-2139.

Sprague-Dawley rats

Titanium particle-induced femoral implant loosening model

Intraperitoneal injection

20 mg/kg/day

Once daily for 4 or 12 weeks

Evaluate the preventive effect of SPC on titanium particle-induced implant loosening, results showed SPC inhibited osteoclast formation, reduced pseudomembrane formation, improved bone-implant contact, and enhanced implant stability

Br J Pharmacol. 2018 Mar;175(6):859-876.

Guinea pigs

Isoprenaline-induced arrhythmia model

Perfusion

300 μmol/L

Single administration, lasting 11-17 minutes

To study the effects of sophocarpine on isoprenaline-induced arrhythmia, results showed that sophocarpine reversed arrhythmia and decreased heart rate.

Acta Pharmacol Sin. 2011 Mar;32(3):311-20.

Sprague-Dawley rats

AGEs-induced aortic endothelial cell injury model

Intraperitoneal injection

40 mg/kg/day

Once daily for 10 consecutive days

To evaluate the protective effects of Sophocarpine on AGEs-induced oxidative stress and apoptosis in aortic endothelial cells. Results showed that Sophocarpine significantly suppressed AGEs-induced ROS production and apoptosis, restored phosphorylation of MKK3/6 and p38 MAPK, and promoted Nrf2 nuclear translocation and antioxidant enzyme expression.

J Am Heart Assoc. 2017 Dec 2;6(12):e007441.

Sophocarpine monohydrate/槐果碱水合物参考文献

Sophocarpine monohydrate/槐果碱水合物实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.78mL

0.76mL

0.38mL

18.91mL

3.78mL

1.89mL

37.83mL

7.57mL

3.78mL

Sophocarpine monohydrate/槐果碱水合物技术信息

CAS号	145572-44-7
分子式	C₁₅H₂₄N₂O₂
分子量	264.36
SMILES Code	O=C1C=CC[C@]2([H])[C@@]3([H])CCCN4[C@@]3([H])[C@](CCC4)([H])CN21.[H]O[H]
MDL No.	MFCD26960838

别名	槐果碱
运输	蓝冰

存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Sealed in dry,2-8°C

溶解方案

细胞实验：

DMSO: 105 mg/mL(397.18 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验：请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用；以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

方案二

方案三

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