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Honokiol/和厚朴酚 {[allProObj[0].p_purity_real_show]}

货号：A146214 同义名： NSC 293100

Honokiol是一种具有强效抗氧化、抗炎、抗血管生成和抗癌活性的双苯植物化学物，通过靶向多种信号分子抑制 Akt 激活，并能轻易穿过血脑屏障。

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

Honokiol/和厚朴酚化学结构
CAS号：35354-74-6

Honokiol/和厚朴酚 3D分子结构
CAS号：35354-74-6

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Honokiol/和厚朴酚纯度/质量文件产品仅供科研

货号：A146214 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]; • Cell, 2025. Ambeed. [ A122167 ]; • Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]; • Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]; • Nat. Nanotechnol., 2025. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]; 更多 >

Akt 亚型比较

产品名称	Akt ↓ ↑	Akt1 ↓ ↑	Akt2 ↓ ↑	Akt3 ↓ ↑	其他靶点	纯度
Honokiol	✔				MEK	98%
PF-04691502	++++ P-Akt (S473), IC50: 3.8 nM P-Akt (T308), IC50: 7.5 nM					98+%
PHT-427	+ Akt, Ki: 2.7 μM					99%+
Deguelin	✔				PI3K	99%+
TIC10 isomer	✔				ERK	98+%
Perifosine	+ Akt, IC50: 4.7 μM					98%
Miltefosine	✔				PKC,PI3K	98%
Triciribine	+ Akt, IC50: 130 nM					99%+
Uprosertib		+ Akt1, IC50: 180 nM	+ Akt2, IC50: 328 nM	++ Akt3, IC50: 38 nM		99%+
Afuresertib		++++ Akt1, Ki: 0.08 nM	++++ Akt2, Ki: 2 nM	++++ Akt3, Ki: 2.6 nM		99%+
Miransertib		++++ Akt1, IC50: 5 nM	++++ Akt2, IC50: 4.5 nM	++ Akt3, IC50: 16 nM		98+%
GSK-690693		++++ Akt1, IC50: 2 nM	+++ Akt2, IC50: 13 nM	+++ Akt3, IC50: 9 nM		99%+
AT7867		++ Akt1, IC50: 32 nM	++ Akt2, IC50: 17 nM	++ Akt3, IC50: 47 nM	PKA	99%+
AKT inhibitor VIII		++ Akt1, IC50: 58 nM	+ Akt2, IC50: 210 nM	+ Akt3, IC50: 2119 nM		97%
MK-2206 2HCl		+++ Akt1, IC50: 8 nM	+++ Akt2, IC50: 12 nM	+ Akt3, IC50: 65 nM		99%+
Ipatasertib		++++ Akt1, IC50: 5 nM	++ Akt2, IC50: 18 nM	+++ Akt3, IC50: 8 nM		99%+
AT13148		++ Akt1, IC50: 38 nM	+ Akt2, IC50: 402 nM	++ Akt3, IC50: 50 nM	PKA	95%
Capivasertib		++++ Akt1, IC50: 3 nM	+++ Akt2, IC50: 8 nM	+++ Akt3, IC50: 8 nM		99%+
A-674563 HCl		+++ Akt1, Ki: 11 nM			PKA	99%
CCT128930			+++ Akt2, IC50: 6 nM		PKA	95%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Honokiol/和厚朴酚生物活性

靶点

描述

Honokiol is a phenylpropanoid molecule, a biaryl-type lignan, present in the genus Magnolia. Neonatal rats, when injected with honokiol (10 mg/kg), acute pain response was subdued. And the application of 25 mg/kg honokiol to guinea pig models lowered the testosterone level^[3]. In addition,honokiol was able to prevent doxorubicin (Dox)-induced senescence of H9c2 cardiomyocytes ^[4]. Honokiol (10 mg/kg, orally) effectively reversed the hepatotoxicity indices elevations and abnormal histopathological changes induced by Concanavalin A (Con A)^[5].

Honokiol/和厚朴酚细胞研究

细胞系	浓度	检测类型	检测时间	活性说明	数据源
HEK293 cells		Function assay		Agonist activity at RXRalpha in HEK293 cells assessed as transcriptional activation after 48 hrs by luciferase reporter gene assay, EC50=11.8 μM	20695472
HEK293 cells		Function assay	24-48 h	Agonist activity at human RXR-alpha expressed in HEK293 cells coexpressing with pCMX-beta-gal after 24 to 48 hrs by luciferase reporter gene assay	24959987
Hep-G2 cells		Cytotoxicity assay		Cytotoxicity of compound against human liver tumor cell line (Hep-G2) was determined, IC50=16.5 μM	15582432
human A2780 cells		Proliferation assay		Antiproliferative activity against cisplatin-sensitive human A2780 cells by MTT assay, IC50=30.5 μM	19589678

Honokiol/和厚朴酚参考文献

[1]Ishitsuka K, Hideshima T, et al. Honokiol overcomes conventional drug resistance in human multiple myeloma by induction of caspase-dependent and -independent apoptosis. Blood. 2005 Sep 1;106(5):1794-800.

[2]Bai X, Cerimele F, et al. Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. J Biol Chem. 2003 Sep 12;278(37):35501-7.

[3]Wu XY, Zhang CX, Deng LC, Xiao J, Yuan X, Zhang B, Hou ZB, Sheng ZH, Sun L, Jiang QC, Zhao W. Overexpressed D2 Dopamine Receptor Inhibits Non-Small Cell Lung Cancer Progression through Inhibiting NF-κB Signaling Pathway. Cell Physiol Biochem. 2018;48(6):2258-2272. doi: 10.1159/000492644. Epub 2018 Aug 16. PMID: 30114693.

[4]Huang PP, Fu J, Liu LH, Wu KF, Liu HX, Qi BM, Liu Y, Qi BL. Honokiol antagonizes doxorubicin‑induced cardiomyocyte senescence by inhibiting TXNIP‑mediated NLRP3 inflammasome activation. Int J Mol Med. 2020 Jan;45(1):186-194. doi: 10.3892/ijmm.2019.4393. Epub 2019 Nov 1. PMID: 31746354; PMCID: PMC6889937.

[5]Elfeky MG, Mantawy EM, Gad AM, Fawzy HM, El-Demerdash E. Mechanistic aspects of antifibrotic effects of honokiol in Con A-induced liver fibrosis in rats: Emphasis on TGF-β/SMAD/MAPK signaling pathways. Life Sci. 2020 Jan 1;240:117096. doi: 10.1016/j.lfs.2019.117096. Epub 2019 Nov 21. PMID: 31760097.

Honokiol/和厚朴酚实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.75mL

0.75mL

0.38mL

18.77mL

3.75mL

1.88mL

37.55mL

7.51mL

3.75mL

Honokiol/和厚朴酚技术信息

CAS号	35354-74-6
分子式	C₁₈H₁₈O₂
分子量	266.33
SMILES Code	OC1=CC=C(C=C1CC=C)C1=CC(CC=C)=CC=C1O
MDL No.	MFCD00016674

别名	NSC 293100
运输	蓝冰
InChI Key	FVYXIJYOAGAUQK-UHFFFAOYSA-N
Pubchem ID	72303

存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Sealed in dry, 2-8°C

溶解方案

细胞实验：

DMSO: 50 mg/mL(187.73 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验：请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用；以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

方案二

方案三

配制的工作液建议现用现配，短期内尽快用完。以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

方案一

细胞研究

细胞系	浓度	检测类型	检测时间	活性说明	数据源

HEK293 cells		Function assay		Agonist activity at RXRalpha in HEK293 cells assessed as transcriptional activation after 48 hrs by luciferase reporter gene assay, EC50=11.8 μM	20695472
HEK293 cells		Function assay	24-48 h	Agonist activity at human RXR-alpha expressed in HEK293 cells coexpressing with pCMX-beta-gal after 24 to 48 hrs by luciferase reporter gene assay	24959987
Hep-G2 cells		Cytotoxicity assay		Cytotoxicity of compound against human liver tumor cell line (Hep-G2) was determined, IC50=16.5 μM	15582432
human A2780 cells		Proliferation assay		Antiproliferative activity against cisplatin-sensitive human A2780 cells by MTT assay, IC50=30.5 μM	19589678
human A549 cell		Cytotoxicity assay	24 h	Cytotoxicity against human A549 cells after 24 hrs by MTS assay, IC50=12.51 μM	22533983
human A549 cells		Cytotoxicity assay		Cytotoxicity against human A549 cells after 72 hrs by MTS assay, IC50=7.75 μM	22533983
human CEM cells		Cytotoxicity assay		Cytotoxicity against human CEM cells, IC50=10.9 μM	17587572
human HepG2 cells		Proliferation assay	24 h	Antiproliferative activity against human HepG2 cells after 24 hrs by MTT assay, IC50=16.5 μM	21853991
human HT-29 cells		Cytotoxicity assay	72 h	Cytotoxicity against human HT-29 cells after 72 hrs by MTS assay, IC50=13.24 μM	22533983
human K562 cells		Proliferation assay		Antiproliferative activity against human K562 cells by MTT assay, IC50=21.1 μM	19589678
human PBM cells		Cytotoxicity assay		Cytotoxicity against human PBM cells, IC50=16.1 μM	17587572
human SH-SY5Y cells	10 μM	Function assay	30 mins	Neuroprotective activity in human SH-SY5Y cells assessed as inhibition of CHP and TBHP-induced cell death at 10 uM incubated for 30 mins prior to challenge measured after 3 hrs by MTT assay	22142539
human SPC-A1 cells		Proliferation assay		Antiproliferative activity against human SPC-A1 cells by MTT assay, IC50=36.1 μM	19589678
human UACC-903 cells		Cytotoxicity assay		Cytotoxicity against human UACC-903 cells after 72 hrs by MTS assay, IC50=5.1 μM	22533983
human UACC-903 cells		Cytotoxicity assay		Cytotoxicity against human UACC-903 cells after 24 hrs by MTS assay, IC50=7.45 μM	22533983
HUVEC cells	20 μM	Function assay	24 h	Antimigratory activity against human HUVEC cells at 20 uM after 24 hrs by wound-healing assay	21853991
Vero cells		Cytotoxicity assay		Cytotoxicity against Vero cells, IC50=22.5 μM	16722664
Vero E6 cells		Function assay		Antiviral activity against SARS coronavirus in Vero E6 cells assessed as inhibition of viral replication by ELISA, EC50=6.5 μM	17663539

Honokiol/和厚朴酚 {[allProObj[0].p_purity_real_show]}

Honokiol/和厚朴酚纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

Honokiol/和厚朴酚质控信息

Honokiol/和厚朴酚生物活性

Honokiol/和厚朴酚细胞研究

Honokiol/和厚朴酚参考文献

Honokiol/和厚朴酚实验方案

Honokiol/和厚朴酚技术信息

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全球学术期刊中引用的产品

Honokiol/和厚朴酚 质控信息

Honokiol/和厚朴酚 生物活性

Honokiol/和厚朴酚 细胞研究

Honokiol/和厚朴酚 参考文献

Honokiol/和厚朴酚 实验方案

Honokiol/和厚朴酚 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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Honokiol/和厚朴酚纯度/质量文件产品仅供科研

Honokiol/和厚朴酚质控信息

Honokiol/和厚朴酚生物活性

Honokiol/和厚朴酚细胞研究

Honokiol/和厚朴酚参考文献

Honokiol/和厚朴酚实验方案

Honokiol/和厚朴酚技术信息