Quercetin Dihydrate | Quercetin dihydrate | Sophoretin | 槲皮素,二水 | Plant Standard | PI3K

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Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

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产品名称	C2β ↓ ↑	p110α ↓ ↑	p110β ↓ ↑	p110γ ↓ ↑	p110δ ↓ ↑	PI3K ↓ ↑	Vps34 ↓ ↑	其他靶点	纯度
A66	+ C2β, IC50: 462 nM	++ p110α, IC50: 32 nM							99%+
Taselisib	+ C2β, IC50: 292 nM	++++ PI3Kα, Ki: 0.29 nM	+++ PI3Kβ, Ki: 9.1 nM	++++ PI3Kγ, Ki: 0.97 nM	++++ PI3Kδ, Ki: 0.12 nM		+ hVps34, IC50: 374 nM		99%+
Gedatolisib		++++ PI3Kα, IC50: 0.4 nM		+++ PI3Kγ, IC50: 5.4 nM				mTOR	99%
HS-173		++++ PI3Kα , IC50: 0.8 nM							99%+
Serabelisib		+++ PI3Kα, IC50: 21 nM							99%+
GNE-477		++++ PI3Kα, IC50: 4 nM						mTOR	99%
YM-201636		+ p110α, IC50: 3.3 μM						PIKfyve	98%
AS-252424		+ PI3Kα, IC50: 935 nM		++ PI3Kγ, IC50: 33 nM					99%
Alpelisib		+++ PI3Kα, IC50: 5 nM							99%+
AS-604850		+ PI3Kα, IC50: 4.5 μM		+ PI3Kγ, IC50: 0.25 μM					99%
SF2523		++ PI3Kα, IC50: 34 nM		++ PI3Kγ, IC50: 158 nM				mTOR,DNA-PK	99%+
Inavolisib		++++ PI3K alpha, IC50: 0.038 nM							99%+
Bimiralisib		++++ PI3Kα, Kd: 1.5 nM	+++ PI3Kβ, Kd: 11 nM	++ PI3Kγ, Kd: 25 nM	++ PI3Kδ, Kd: 25 nM			mTOR	99%+
GSK1059615		++++ PI3Kα, IC50: 0.4 nM	++++ PI3Kβ, IC50: 0.6 nM	+++ PI3Kγ, IC50: 5 nM	++++ PI3Kδ, IC50: 2 nM			mTOR	98%
GSK2636771			✔						99%
Fimepinostat		+++ PI3Kα, IC50: 19 nM	++ PI3Kβ, IC50: 54 nM		++ PI3Kδ, IC50: 39 nM				99%+
VS-5584		++++ PI3Kα, IC50: 2.6 nM	+++ PI3Kβ, IC50: 21 nM	++++ PI3Kγ, IC50: 3.0 nM	++++ PI3Kδ, IC50: 2.7 nM			mTOR	98%
Dactolisib		++++ p110α1, IC50: 4 nM	++ p110β, IC50: 75 nM	+++ p110γ, IC50: 5 nM	+++ p110δ, IC50: 7 nM				98+%
PI-103		++++ p110α, IC50: 2 nM	++++ p110β, IC50: 3 nM	+++ p110γ, IC50: 15 nM	++++ p110δ, IC50: 3 nM			mTOR,DNA-PK	99%+
PI-3065			+ p110β, IC50: 1078 nM		+++ p110δ, IC50: 15 nM				99%+
Voxtalisib		++ PI3Kα, IC50: 39 nM	++ PI3Kβ, IC50: 113 nM	+++ PI3Kγ, IC50: 9 nM	++ PI3Kδ, IC50: 43 nM			mTOR,DNA-PK	99%+
AZD-8835		+++ PI3Kα, IC50: 6.2 nM	+ PI3Kβ, IC50: 431 nM	++ PI3Kγ, IC50: 90 nM	+++ PI3Kδ, IC50: 5.7 nM				99%
Pilaralisib analogue		++ PI3Kα, IC50: 39 nM	++ PI3Kβ, IC50: 36 nM	+++ PI3Kγ, IC50: 23 nM	++ PI3Kδ, IC50: 36 nM				99%+
ZSTK474		+++ PI3Kα, IC50: 16 nM	++ PI3Kβ, IC50: 44 nM	++ PI3Kγ, IC50: 49 nM	+++ PI3Kδ, IC50: 4.6 nM	++ PI3K, IC50: 37 nM			98%
AS-605240		++ PI3Kα, IC50: 60 nM	+ PI3Kβ, IC50: 270 nM	+++ PI3Kγ, IC50: 8 nM	+ PI3Kδ, IC50: 300 nM				98%
TGX-221			+++ p110β, IC50: 5 nM		++ p110δ, IC50: 0.1 μM				99%+
PF-04691502		++++ PI3Kα, Ki: 1.8 nM	++++ PI3Kβ, Ki: 2.1 nM	++++ PI3Kγ, Ki: 1.9 nM	++++ PI3Kδ, Ki: 1.6 nM			mTOR	98+%
GDC-0084		++++ PI3Kα, Ki app: 2 nM	++ PI3Kβ, Ki app: 46 nM	+++ PI3Kγ, Ki app: 10 nM	++++ PI3Kδ, Ki app: 3 nM			mTOR	99%+
Buparlisib		++ p110α, IC50: 52 nM	+ p110β, IC50: 166 nM	+ p110γ, IC50: 262 nM	++ p110δ, IC50: 116 nM		+ Vps34, IC50: 2.4 μM	mTOR	98%
LY294002		+ p110α, IC50: 0.5 μM	+ p110β, IC50: 0.97 μM		+ p110δ, IC50: 0.57 μM			DNA-PK	99%+
AZD 6482		+ PI3Kα, IC50: 870 nM	+++ PI3Kβ, IC50: 10 nM		++ PI3Kδ, IC50: 80 nM			DNA-PK	99%+
Pictilisib		++++ p110α, IC50: 3 nM	++ p110β, IC50: 33 nM	++ p110γ, IC50: 75 nM	++++ p110δ, IC50: 3 nM			mTOR	99%+
PKI-402		++++ PI3Kα, IC50: 2 nM	+++ PI3Kβ, IC50: 7 nM	+++ PI3Kγ, IC50: 16 nM	+++ PI3Kδ, IC50: 14 nM			mTOR	98%
Copanlisib		++++ PI3Kα, IC50: 0.5 nM	++++ PI3Kβ, IC50: 3.7 nM	+++ PI3Kγ, IC50: 6.4 nM	++++ PI3Kδ, IC50: 0.7 nM				99%+
Omipalisib		++++ p110α, Ki: 0.019 nM	++++ p110β, Ki: 0.13 nM	++++ p110γ, Ki: 0.06 nM	++++ p110δ, Ki: 0.024 nM				99%+
Izorlisib		+++ PI3Kα, IC50: 14 nM	++ PI3Kβ, IC50: 0.12 μM	++ PI3Kγ, IC50: 36 nM	+ PI3Kδ, IC50: 0.50 μM				99%+
AZD8186		++ PI3Kα, IC50: 35 nM	++++ PI3Kβ, IC50: 4 nM		+++ PI3Kδ, IC50: 12 nM				99%
KU-0060648		++++ PI3Kα, IC50: 4 nM	++++ PI3Kβ, IC50: 0.5 nM	+ PI3Kγ, IC50: 0.59 μM	++++ PI3Kδ, IC50: 0.1 nM			DNA-PK	98%
Apitolisib		+++ p110α, IC50: 5 nM	++ p110β, IC50: 27 nM	+++ p110γ, IC50: 14 nM	+++ p110δ, IC50: 7 nM			mTOR	98%+
CZC24832			+ PI3Kβ, IC50: 1.1 μM	++ PI3Kγ, IC50: 27 nM					98+%
BGT226 maleate		++++ PI3Kα, IC50: 4 nM	++ PI3Kβ, IC50: 63 nM	++ PI3Kγ, IC50: 38 nM				mTOR	99%+
TG 100713		++ PI3Kα, IC50: 165 nM	+ PI3Kβ, IC50: 215 nM	++ PI3Kγ, IC50: 50 nM	+++ PI3Kδ, IC50: 24 nM				98%+
PI3K-IN-1		++ PI3Kα, IC50: 39 nM	++ PI3Kβ, IC50: 113 nM	+++ PI3Kγ, IC50: 9 nM	++ PI3Kδ, IC50: 43 nM			mTOR,DNA-PK	98+%
TG100-115		+ PI3Kα, IC50: 1.3 μM	+ PI3Kβ, IC50: 1.2 μM	++ PI3Kγ, IC50: 83 nM	+ PI3Kδ, IC50: 235 nM				98%
PIK-90		+++ PI3Kα, IC50: 11 nM	+ PI3Kβ, IC50: 350 nM	+++ PI3Kγ, IC50: 18 nM	++ PI3Kδ, IC50: 58 nM				99%+
PIK-294			+ p110β, IC50: 490 nM	++ p110γ, IC50: 160 nM	+++ p110δ, IC50: 10 nM				99%+
Duvelisib			++++ PI3Kβ, Ki: 1564 pM	++ PI3Kγ, Ki: 243 pM	++++ PI3Kδ, Ki: 23 pM				99%+
GDC-0326		++++ PI3Kα, Ki: 0.2 nM	++ PI3Kβ, Ki: 26.6 nM	+++ PI3Kγ, Ki: 10.2 nM	++++ PI3Kδ, Ki: 4 nM				98%
Quercetin Dihydrate			+ PI3Kβ, IC50: 5.4 μM	+ PI3Kγ, IC50: 2.4 μM	+ PI3Kδ, IC50: 3.0 μM				95%
Quercetin			+ PI3Kβ, IC50: 5.4 μM	+ PI3Kγ, IC50: 2.4 μM	+ PI3Kδ, IC50: 3.0 μM			Src,Sirtuin,PKC	95%
Leniolisib		+ PI3Kα, IC50: 0.244 μM	+ PI3Kβ, IC50: 0.424 μM	+ PI3Kγ, IC50: 2.23 μM	+++ PI3Kδ, IC50: 0.011 μM			DNA-PK	99%+
PIK-108			✔						99%
Eganelisib				+++ PI3Kγ, IC50: 16 nM					99%+
CAY10505				✔					99%
IPI-3063					++++ p110δ, IC50: 2.5 nM				99%
Nemiralisib					++++ PI3Kδ, pKi: 9.9				99%+
PF-4989216		++++ p110α, IC50: 2 nM		++ p110γ, IC50: 65 nM	++++ p110δ, IC50: 1 nM				99%+
PIK-75 HCl		+++ p110α, IC50: 5.8 nM		++ p110γ, IC50: 76 nM	+ p110δ, IC50: 0.51 μM			DNA-PK	99%+
Tenalisib				++ PI3Kγ, IC50: 33.2 nM	++ PI3Kδ, IC50: 24.5 nM				98%
Acalisib					+++ p110δ, IC50: 14 nM				99%+
Umbralisib					+++ PI3Kδ, IC50: 22.2 nM				99%+
AMG319				+ PI3Kγ, IC50: 850 nM	+++ PI3Kδ, IC50: 18 nM				99%
IC-87114				+ PI3Kγ, IC50: 29 μM	+ PI3Kδ, IC50: 0.5 μM				99%+
Idelalisib				++ p110γ, IC50: 89 nM	++++ p110δ, IC50: 2.5 nM				98%
PIK-293				+ p110γ, IC50: 10 μM	+ p110δ, IC50: 0.24 μM				99%+
Vps34-PIK-III					+ PI3Kδ, IC50: 1.2μM		+++ Vps34, IC50: 0.018μM		99%+
GSK2292767					✔				98%
Seletalisib				+ PI3Kγ, IC50: 282 nM	+++ PI3Kδ, IC50: 12 nM				99%+
P110δ-IN-1					++++ P110δ, IC50: 0.6 nM				99%
PI3Kδ-IN-5					++++ PI3Kδ, IC50: 0.9 nM				99%
SRX3207		+ PI3K alpha, IC50: 244 nM		+ PI3K gamma, IC50: 9790 nM	+ PI3K delta, IC50: 388 nM			Syk	98%
Parsaclisib HCl					++++ PI3Kδ, IC50: 1 nM				98%
IHMT-PI3Kδ-372					+++ PI3Kδ, IC50: 14 nM				98%
Trigonelline						✔		Akt	99%+
Wortmannin						++++ PI3K, IC50: 3 nM		MLCK,DNA-PK	99%+
Samotolisib						✔		DNA-PK	99%+
GNE-317						✔			99%+
Oroxin B						✔		PTEN,Akt	99%+
NU 7026						+ PI3K, IC50: 13 μM		DNA-PK	98+%
Deguelin						✔		Akt	99%+
Ailanthone						✔		ATM/ATR,CDK,Akt	98%
Resibufogenin						✔		ROS	98%
KU-57788						+ PI3K, IC50: 5 μM		mTOR,DNA-PK	99%+
Cinobufagine						✔		Akt	99%
α-Linolenic acid						✔			97% (GC)
MTX-211						✔		EGFR	98%
PI3K/mTOR Inhibitor-2						++++ PI3K, IC50: 3.4 nM		mTOR	99%+
SPP-86						✔			99%+
(E)-Akt inhibitor-IV						✔			98%
Vps34-IN-1							++ Vps34, IC50: 25 nM		98%
SAR405							++++ Vps34, IC50: 1.2 nM		98+%
3-Methyladenine				+ PI3Kγ, IC50: 60 μM			+ Vps34, IC50: 25 μM	Autophagy	98%
Vps34-IN-4							+++ VPS34, IC50: 15 nM		98%+
Autophinib							+++ Vps34, IC50: 19 nM	Autophagy	99%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Cell Line Human Periodontal Ligament Cells (hPDLCs) HK-2 human renal tubule epithelial cells HEK293 cells HEK293 cells ER-α/ER-β reporter cells C2C12 skeletal muscle cells AMJ2-C11 cells LA-4 cells HBEC4 cells MIN-6 cells MIN-6 cells	Concentration	Treated Time	Description	References
Human Periodontal Ligament Cells (hPDLCs)	5 μM	24 h	Quercetin at 5 μM strongly activated NRF2 signaling, alleviated oxidative damage and enhanced the antioxidant capacity of hPDLCs.	Drug Des Devel Ther. 2021 Aug 12;15:3509-3522.
HK-2 human renal tubule epithelial cells	5 μM	48 h	Quercetin significantly reduced the accumulation of fibrosis- and inflammation-related proteins induced by IL-33, improved renal cell pyroptosis, and acted through the IL-33/ST2 pathway.	Antioxidants (Basel). 2022 Nov 13;11(11):2238.
HEK293 cells	10 μM		To investigate the inhibitory effect of Quercetin on hP2X3 receptors, results showed that Quercetin inhibited hP2X3 with an IC50 of 4.72 ± 0.35 μM.	Nat Commun. 2023 Sep 20;14(1):5844.
HEK293 cells	100 μM		To investigate the inhibitory effect of Quercetin on hP2X1, hP2X4, and hP2X7 receptors, results showed that Quercetin inhibited hP2X1 by 21.4 ± 5.0%, with almost no inhibition of hP2X4 and hP2X7.	Nat Commun. 2023 Sep 20;14(1):5844.
ER-α/ER-β reporter cells	0.023–50 µg/mL	24 h	Quercetin had a small effect on ER-α but strongly activated ER-β, with an ER-β/ER-α specificity of 3.2.	Int J Mol Sci. 2021 Jan 21;22(3):1032.
C2C12 skeletal muscle cells	25, 50, 75, 100 µM	24 h	Quercetin significantly increased the viability of dexamethasone-treated C2C12 skeletal muscle cells and exerted antiapoptotic effects by regulating mitochondrial membrane potential (ΔΨm) and reducing oxidative species.	Molecules. 2020 Jul 17;25(14):3267.
AMJ2-C11 cells	0, 5, 10, 20 μM	4 or 8 h	To investigate the induction of HO-1 mRNA and protein expression by quercetin, results showed that quercetin dose-dependently induced HO-1 expression.	Respir Res. 2014 Nov 21;15(1):150.
LA-4 cells	0, 5, 10, 20 μM	4 or 8 h	To investigate the induction of HO-1 mRNA and protein expression by quercetin, results showed that quercetin dose-dependently induced HO-1 expression.	Respir Res. 2014 Nov 21;15(1):150.
HBEC4 cells	0, 5, 10, 20 μM	4 or 8 h	To investigate the induction of HO-1 mRNA and protein expression by quercetin, results showed that quercetin dose-dependently induced HO-1 expression.	Respir Res. 2014 Nov 21;15(1):150.
MIN-6 cells	10 μM	1 h	To investigate the effect of Quercetin on insulin secretion, results showed that 10 μM Quercetin significantly increased insulin secretion in the presence of 8.3 mmol/L glucose.	Drug Des Devel Ther. 2018 Apr 23;12:955-966.
MIN-6 cells	10 μM	24 h	To investigate the effect of Quercetin on palmitic acid-induced apoptosis in MIN-6 cells, results showed that 10 μM Quercetin significantly improved cell viability.	Drug Des Devel Ther. 2018 Apr 23;12:955-966.

Species C57BL/6 mice MRL/lpr mice Mice C57BL/6 mice Mice BALB/c mice Db/db mice	Animal Model Periodontitis model Systemic lupus erythematosus (SLE) model Sod1KO mice Chronic cough model Triple-transgenic Alzheimer's disease model mice LPS-induced acute lung injury model Type 2 diabetes model	Administration	Dosage	Frequency	Description	References
C57BL/6 mice	Periodontitis model	Oral gavage	50 mg/kg	Once daily for 10 days	Quercetin reduced oxidative stress levels and slowed alveolar bone absorption in periodontitis mice by activating the NRF2 signaling pathway.	Drug Des Devel Ther. 2021 Aug 12;15:3509-3522.
MRL/lpr mice	Systemic lupus erythematosus (SLE) model	Oral gavage	40 mg/kg	Once daily for three months	Quercetin improved renal function and inhibited the expression of fibrosis- and inflammation-related markers in MRL/lpr mice.	Antioxidants (Basel). 2022 Nov 13;11(11):2238.
Mice	Sod1KO mice	Oral gavage	50 mg/kg	Three consecutive days every 15 days for 7 months	To study the effect of D + Q on inflammation and hepatocellular carcinoma in the livers of Sod1KO mice. The results showed that D + Q significantly reduced markers of inflammation and the incidence of hepatocellular carcinoma in the livers of Sod1KO mice.	Aging Cell. 2022 Aug;21(8):e13676
C57BL/6 mice	Chronic cough model	Oral	150 mg/kg	Twice daily for 7 days	To investigate the cough-relieving effect of Quercetin on chronic cough, results showed that 150 mg/kg Quercetin significantly reduced the frequency of coughing in mice.	Nat Commun. 2023 Sep 20;14(1):5844.
Mice	Triple-transgenic Alzheimer's disease model mice	Oral	100 mg/kg	Every 48 hours for one year	To evaluate the effect of long-term oral administration of Quercetin on neurodegeneration markers and cognitive function in triple-transgenic Alzheimer's disease model mice. The results showed that Quercetin significantly reduced β-amyloid aggregation and partially reduced tau hyperphosphorylation, thereby improving cognitive function in mice.	Molecules. 2019 Jun 20;24(12):2287
BALB/c mice	LPS-induced acute lung injury model	Intratracheal administration	10μM,50μl	Single dose 6 hours before LPS challenge	To investigate the protective effects of quercetin on LPS-induced acute lung injury, results showed that quercetin pretreatment significantly attenuated LPS-induced pulmonary edema and inflammation.	Respir Res. 2014 Nov 21;15(1):150.
Db/db mice	Type 2 diabetes model	Intragastric administration	0.5 g/kg	Once daily for 4 weeks	To investigate the effect of Quercetin on glucose tolerance and insulin secretion in db/db mice, results showed that Quercetin significantly improved glucose tolerance and insulin secretion.	Drug Des Devel Ther. 2018 Apr 23;12:955-966.

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01881919	Hyperuricemia ... 展开 >> Gout Kidney Calculi Diabetes Cardiovascular Disease 收起 <<	Early Phase 1	Completed	-	United Kingdom ... 展开 >> School of Food Science and Nutrition Leeds, West Yorkshire, United Kingdom, LS2 9JT 收起 <<

CAS号	6151-25-3
分子式	C₁₅H₁₄O₉
分子量	338.27
SMILES Code	O=C1C(O)=C(C2=CC=C(O)C(O)=C2)OC3=C1C(O)=CC(O)=C3.[H]O[H].[H]O[H]
MDL No.	MFCD00149487

别名	槲皮素,二水 ;Sophoretin
运输	蓝冰
InChI Key	GMGIWEZSKCNYSW-UHFFFAOYSA-N
Pubchem ID	5284452

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p110γ	PI3Kγ, IC50:2.4 μM
p110β	PI3Kβ, IC50:5.4 μM
p110δ	PI3Kδ, IC50:3.0 μM
SIRT1

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