Cinobufagin, a natural product isolated and purified from the glandular body of Bufo bufo gargarizans Cantor, inhibits the proliferation and induces apoptosis, may be related to the mitochondria-mediated pathway and GSK-3β/NF-κB pathway, can significantly relieve cancer pain in mice and raised their pain threshold, mainly upregulating the expression levels of β -END and μ -OR in the hind paw tumor and adjacent tissue, and act as a potent anticancer agent against MM and possibly exerts its effects through the ROS-mediated activation of ERK, JNK and p38 MAPK leading to the activation of caspase-3 in U266 cells.
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Cinobufagin, a natural product isolated and purified from the glandular body of Bufo bufo gargarizans Cantor, inhibits the proliferation and induces apoptosis, may be related to the mitochondria-mediated pathway and GSK-3β/NF-κB pathway, can significantly relieve cancer pain in mice and raised their pain threshold, mainly upregulating the expression levels of β -END and μ -OR in the hind paw tumor and adjacent tissue, and act as a potent anticancer agent against MM and possibly exerts its effects through the ROS-mediated activation of ERK, JNK and p38 MAPK leading to the activation of caspase-3 in U266 cells.
Cinobufagine/华蟾蜍精 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
C57BL/6J mice
Intracranial glioma model (GL261 and CT2A cells)
Intraperitoneal injection
5 mg/kg
Every other day for a total of five doses
To evaluate the effect of cinobufagin alone or in combination with anti-PD-1 antibody on tumor growth and survival. Results showed that cinobufagin significantly inhibited tumor growth and prolonged survival, with a more pronounced therapeutic effect when combined with anti-PD-1 antibody.
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