KU-57788 | NU7441 | DNA-PK Inhibitor | AmBeed-信号通路专用抑制剂

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KU-57788 {[allProObj[0].p_purity_real_show]}

货号：A118825 同义名： NU7441

KU-57788是一种强效且选择性的 DNA-依赖性蛋白激酶 (DNA-PK) 抑制剂，IC50 为 14 nM，并在无细胞实验中抑制 PI3K，IC50 为 5 μM。NU7441在CRISPR-Cas9基因编辑中减少NHEJ的频率，并增加HDR的效率。

KU-57788 化学结构
CAS号：503468-95-9

KU-57788 3D分子结构
CAS号：503468-95-9

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KU-57788 纯度/质量文件产品仅供科研

货号：A118825 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]; • Cell, 2025. Ambeed. [ A122167 ]; • Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]; • Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]; • Nat. Nanotechnol., 2025. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]; 更多 >

DNA-PK 亚型比较
表观遗传阅读框亚型比较
PI3K 亚型比较

产品名称	DNA-PK ↓ ↑	其他靶点	纯度
PI-103	++ DNA-PK, IC50: 23 nM		99%+
CC-115	+++ DNA-PK, IC50: 0.013 μM	mTOR	98+%
Samotolisib	✔		99%+
NU 7026	+ DNA-PK, IC50: 0.23 μM	PI3K	98+%
PIK-75 HCl	++++ DNA-PK, IC50: 2 nM		99%+
PP121	+ DNA-PK, IC50: 60 nM	PDGFR,VEGFR	99%+
KU-0060648	++++ DNA-PK, IC50: 5 nM		98%
KU-57788	+++ DNA-PK, IC50: 14 nM		99%+
LTURM34	++ DNA-PK, IC50: 0.034 μM		98%+
SF2523	+++ DNA-PK, IC50: 9 nM		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

产品名称	BET ↓ ↑	bromodomain ↓ ↑	BRPF ↓ ↑	CBP/beta-catenin ↓ ↑	p300/CBP ↓ ↑	其他靶点	纯度
MS436	++ BRD4 (2), Ki: 0.34 μM BRD4 (1), Ki: <0.085 μM						99%+
CPI-203	+++ BRD4, IC50: 37 nM						98+%
GSK1324726A	+++ BRD2, IC50: 31 nM BRD4, IC50: 22 nM						99%+
PFI-1	++ BRD2, IC50: 98 nM BRD4, IC50: 0.22 μM						98%
Apabetalone	+ BD2, IC50: 0.51 μM						99%
(+)-JQ1	+++ BRD4 (1), IC50: 77 nM BRD4 (2), IC50: 33 nM						98%
I-BET151	+ BRD3, IC50: 0.25 μM BRD4, IC50: 0.5 μM						98%
Molibresib	+++ BET proteins, IC50: 35 nM						99%+
I-BRD9	+++ BRD4, pIC50: 5.3 BRD9, pIC50: 7.3						99%+
BI-7273	++++ BRD9, IC50: 19 nM BRD7, IC50: 117 nM						97%
Pelabresib	+++ BRD4-BD1, IC50: 39 nM						98%
ARV-825	+++ BRD4 BD2, Kd: 28 nM BRD4 BD1, Kd: 90 nM						99%+
Birabresib							99%+
BI 2536	+++ BRD4, Kd: 37 nM					c-Myc	99%+
Bromosporine	++ BRD9, IC50: 0.122 μM BRD2, IC50: 0.29 μM	++++ CECR2, IC50: 17 nM					99%+
XMD8-92	++ BRD4 (1), Kd: 170 nM						99%+
Mivebresib	✔						99%+
BI-9564	++++ BRD9, Kd: 5.9 nM BRD7, Kd: 73 nM	++ CECR2, Kd: 77 nM					98%
AZD5153 6-Hydroxy-2-naphthoic acid	++++ FL-BRD4, IC50: 5 nM						99%+
PLX51107	++++ BRD4 BD2, Kd: 1.7 nM BRD3 BD1, Kd: 2.1 nM						99%+
FL-411	+ BRD4(1), IC50: 0.43 μM						99%+
ABBV-744	✔						99%+
dBET6	++++ BRD4, IC50: 14 nM						99%+
dBET1	++++ BRD4, IC50: 20 nM						99%+
MZ1	++++ Brd2(BD2), Kd: 62 nM Brd3(BD2), Kd: 13 nM						99%+
dBET57	+ BRD4_BD1, DC50: 500 nM						99%+
SF2523	+ BRD4, IC50: 241 nM					DNA-PK	99%+
INCB054329	++++ BRD4-BD1, IC50: 119 nM BRD3-BD1, IC50: 9 nM						99%
INCB-057643	✔						99%+
(E/Z)-ZL0420	+++ BRD4 BD1, IC50: 27 nM BRD4 BD2, IC50: 32 nM						99%+
BMS-986158	✔						99%
BRD4 Inhibitor-10	++++ BRD4-BD2, IC50: 41 nM BRD4-BD1, IC50: 5 nM						97%
A1874	✔						99%+
Y06036	++ BRD4 (1), Kd: 82 nM						99%+
Alobresib	✔					NF-κB	95%
ODM-207	✔						98%
GSK778	+++ BRD2-BD1, IC50: 75nM BRD4-BD1, IC50: 143 nM						97%
SRX3207	+ BRD42, IC50: 3070 nM BRD41, IC50: 3070 nM					Syk	98%
GSK046	+++ BRD3_BD2, IC50: 98 nM BRD4_BD2, IC50: 214 nM						98%
GSK620	✔						97%
Trotabresib	✔						99%
NHWD-870	✔						98%
CFT8634	++++ BRD9, DC50: 3 nM						98%
GSK2801		++ BAZ2A, Kd: 257 nM BAZ2B, Kd: 136 nM					99%+
KG-501		✔					99%+
UNC 669		+ L3MBTL4, IC50: 6 μM L3MBTL3, IC50: 35 μM					99%
PFI-3		+++ SMARCA2A, Kd: 72 nM SMARCA4, Kd: 55 nM					99%+
UNC1215		+++ L3MBTL3- D274A, IC50: 3.5 μM L3MBTL3, IC50: 120 nM					99%+
EED226		++ EED, Kd: 82 nM PRC2, Kd: 114 nM					99%+
BRD9539		✔					98%
UNC926		+ L3MBTL1, Kd: 3.9 μM					99%
666-15		++ CREB, IC50: 81 nM					99%+
UNC6852		+ EED, IC50: 247 nM					98%
BAZ1A-IN-1		+ BAZ1A, Kd: 0.52 μM					99%+
PFI-4			++ BRPF1, IC50: 80 nM BRPF2, IC50: 7.9 μM				99%+
OF-1			++ BRPF1B, Kd: 100 nM BRPF2, Kd: 500 nM				99%+
GSK-5959			++ BRPF2, pIC50: 5.2 BRPF3, pIC50: 7.1				99%
GSK6853			++++ BRPF1, pIC50: 8.1				99%+
NI-42			++++ BRPF3, IC50: 260 nM BRPF1, IC50: 48 nM				99%+
E-7386				+++ CBP/beta-catenin, IC50: 0.0484 μM			99%
I-CBP112					++ CBP, Kd: 151 nM p300, Kd: 167 nM		98+%
Histone Acetyltransferase Inhibitor II					+ p300, IC50: 5 μM		98%
C646					+ p300/CBP, Ki: 400 nM		99%+
Anacardic Acid					+ p300/CBP, IC50: 8.5 μM PCAF, IC50: 5 μM		99%+
SGC-CBP30					++++ EP300, IC50: 38 nM CREBBP, IC50: 21 nM		99%+
Nordihydroguaiaretic acid					✔	HER2,IGF-1R	99%+
Curcumin					+ p300, IC50: ~25 μM	Nrf2,Ferroptosis,NF-κB	98%
CPI-637					+++ CBP, IC50: 0.03 μM EP300, IC50: 0.051 μM		99%+
Foscenvivint					✔	β-catenin	99%+
A-485					++ p300 HAT, IC50: 0.06 μM		99%+
GNE-781	+ BRD4(1), IC50: 5100 nM				++++ CBP, IC50: 0.94 nM		99%
NEO2734	+++ BET, IC50: <30 nM				+++ p300/CBP, IC50: <30 nM		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

产品名称	C2β ↓ ↑	p110α ↓ ↑	p110β ↓ ↑	p110γ ↓ ↑	p110δ ↓ ↑	PI3K ↓ ↑	Vps34 ↓ ↑	其他靶点	纯度
A66	+ C2β, IC50: 462 nM	++ p110α, IC50: 32 nM							99%+
Taselisib	+ C2β, IC50: 292 nM	++++ PI3Kα, Ki: 0.29 nM	+++ PI3Kβ, Ki: 9.1 nM	++++ PI3Kγ, Ki: 0.97 nM	++++ PI3Kδ, Ki: 0.12 nM		+ hVps34, IC50: 374 nM		99%+
Gedatolisib		++++ PI3Kα, IC50: 0.4 nM		+++ PI3Kγ, IC50: 5.4 nM				mTOR	99%
HS-173		++++ PI3Kα , IC50: 0.8 nM							99%+
Serabelisib		+++ PI3Kα, IC50: 21 nM							99%+
GNE-477		++++ PI3Kα, IC50: 4 nM						mTOR	99%
YM-201636		+ p110α, IC50: 3.3 μM						PIKfyve	98%
AS-252424		+ PI3Kα, IC50: 935 nM		++ PI3Kγ, IC50: 33 nM					99%
Alpelisib		+++ PI3Kα, IC50: 5 nM							99%+
AS-604850		+ PI3Kα, IC50: 4.5 μM		+ PI3Kγ, IC50: 0.25 μM					99%
SF2523		++ PI3Kα, IC50: 34 nM		++ PI3Kγ, IC50: 158 nM				mTOR,DNA-PK	99%+
Inavolisib		++++ PI3K alpha, IC50: 0.038 nM							99%+
Bimiralisib		++++ PI3Kα, Kd: 1.5 nM	+++ PI3Kβ, Kd: 11 nM	++ PI3Kγ, Kd: 25 nM	++ PI3Kδ, Kd: 25 nM			mTOR	99%+
GSK1059615		++++ PI3Kα, IC50: 0.4 nM	++++ PI3Kβ, IC50: 0.6 nM	+++ PI3Kγ, IC50: 5 nM	++++ PI3Kδ, IC50: 2 nM			mTOR	98%
GSK2636771			✔						99%
Fimepinostat		+++ PI3Kα, IC50: 19 nM	++ PI3Kβ, IC50: 54 nM		++ PI3Kδ, IC50: 39 nM				99%+
VS-5584		++++ PI3Kα, IC50: 2.6 nM	+++ PI3Kβ, IC50: 21 nM	++++ PI3Kγ, IC50: 3.0 nM	++++ PI3Kδ, IC50: 2.7 nM			mTOR	98%
Dactolisib		++++ p110α1, IC50: 4 nM	++ p110β, IC50: 75 nM	+++ p110γ, IC50: 5 nM	+++ p110δ, IC50: 7 nM				98+%
PI-103		++++ p110α, IC50: 2 nM	++++ p110β, IC50: 3 nM	+++ p110γ, IC50: 15 nM	++++ p110δ, IC50: 3 nM			mTOR,DNA-PK	99%+
PI-3065			+ p110β, IC50: 1078 nM		+++ p110δ, IC50: 15 nM				99%+
Voxtalisib		++ PI3Kα, IC50: 39 nM	++ PI3Kβ, IC50: 113 nM	+++ PI3Kγ, IC50: 9 nM	++ PI3Kδ, IC50: 43 nM			mTOR,DNA-PK	99%+
AZD-8835		+++ PI3Kα, IC50: 6.2 nM	+ PI3Kβ, IC50: 431 nM	++ PI3Kγ, IC50: 90 nM	+++ PI3Kδ, IC50: 5.7 nM				99%
Pilaralisib analogue		++ PI3Kα, IC50: 39 nM	++ PI3Kβ, IC50: 36 nM	+++ PI3Kγ, IC50: 23 nM	++ PI3Kδ, IC50: 36 nM				99%+
ZSTK474		+++ PI3Kα, IC50: 16 nM	++ PI3Kβ, IC50: 44 nM	++ PI3Kγ, IC50: 49 nM	+++ PI3Kδ, IC50: 4.6 nM	++ PI3K, IC50: 37 nM			98%
AS-605240		++ PI3Kα, IC50: 60 nM	+ PI3Kβ, IC50: 270 nM	+++ PI3Kγ, IC50: 8 nM	+ PI3Kδ, IC50: 300 nM				98%
TGX-221			+++ p110β, IC50: 5 nM		++ p110δ, IC50: 0.1 μM				99%+
PF-04691502		++++ PI3Kα, Ki: 1.8 nM	++++ PI3Kβ, Ki: 2.1 nM	++++ PI3Kγ, Ki: 1.9 nM	++++ PI3Kδ, Ki: 1.6 nM			mTOR	98+%
GDC-0084		++++ PI3Kα, Ki app: 2 nM	++ PI3Kβ, Ki app: 46 nM	+++ PI3Kγ, Ki app: 10 nM	++++ PI3Kδ, Ki app: 3 nM			mTOR	99%+
Buparlisib		++ p110α, IC50: 52 nM	+ p110β, IC50: 166 nM	+ p110γ, IC50: 262 nM	++ p110δ, IC50: 116 nM		+ Vps34, IC50: 2.4 μM	mTOR	98%
LY294002		+ p110α, IC50: 0.5 μM	+ p110β, IC50: 0.97 μM		+ p110δ, IC50: 0.57 μM			DNA-PK	99%+
AZD 6482		+ PI3Kα, IC50: 870 nM	+++ PI3Kβ, IC50: 10 nM		++ PI3Kδ, IC50: 80 nM			DNA-PK	99%+
Pictilisib		++++ p110α, IC50: 3 nM	++ p110β, IC50: 33 nM	++ p110γ, IC50: 75 nM	++++ p110δ, IC50: 3 nM			mTOR	99%+
PKI-402		++++ PI3Kα, IC50: 2 nM	+++ PI3Kβ, IC50: 7 nM	+++ PI3Kγ, IC50: 16 nM	+++ PI3Kδ, IC50: 14 nM			mTOR	98%
Copanlisib		++++ PI3Kα, IC50: 0.5 nM	++++ PI3Kβ, IC50: 3.7 nM	+++ PI3Kγ, IC50: 6.4 nM	++++ PI3Kδ, IC50: 0.7 nM				99%+
Omipalisib		++++ p110α, Ki: 0.019 nM	++++ p110β, Ki: 0.13 nM	++++ p110γ, Ki: 0.06 nM	++++ p110δ, Ki: 0.024 nM				99%+
Izorlisib		+++ PI3Kα, IC50: 14 nM	++ PI3Kβ, IC50: 0.12 μM	++ PI3Kγ, IC50: 36 nM	+ PI3Kδ, IC50: 0.50 μM				99%+
AZD8186		++ PI3Kα, IC50: 35 nM	++++ PI3Kβ, IC50: 4 nM		+++ PI3Kδ, IC50: 12 nM				99%
KU-0060648		++++ PI3Kα, IC50: 4 nM	++++ PI3Kβ, IC50: 0.5 nM	+ PI3Kγ, IC50: 0.59 μM	++++ PI3Kδ, IC50: 0.1 nM			DNA-PK	98%
Apitolisib		+++ p110α, IC50: 5 nM	++ p110β, IC50: 27 nM	+++ p110γ, IC50: 14 nM	+++ p110δ, IC50: 7 nM			mTOR	98%+
CZC24832			+ PI3Kβ, IC50: 1.1 μM	++ PI3Kγ, IC50: 27 nM					98+%
BGT226 maleate		++++ PI3Kα, IC50: 4 nM	++ PI3Kβ, IC50: 63 nM	++ PI3Kγ, IC50: 38 nM				mTOR	99%+
TG 100713		++ PI3Kα, IC50: 165 nM	+ PI3Kβ, IC50: 215 nM	++ PI3Kγ, IC50: 50 nM	+++ PI3Kδ, IC50: 24 nM				98%+
PI3K-IN-1		++ PI3Kα, IC50: 39 nM	++ PI3Kβ, IC50: 113 nM	+++ PI3Kγ, IC50: 9 nM	++ PI3Kδ, IC50: 43 nM			mTOR,DNA-PK	98+%
TG100-115		+ PI3Kα, IC50: 1.3 μM	+ PI3Kβ, IC50: 1.2 μM	++ PI3Kγ, IC50: 83 nM	+ PI3Kδ, IC50: 235 nM				98%
PIK-90		+++ PI3Kα, IC50: 11 nM	+ PI3Kβ, IC50: 350 nM	+++ PI3Kγ, IC50: 18 nM	++ PI3Kδ, IC50: 58 nM				99%+
PIK-294			+ p110β, IC50: 490 nM	++ p110γ, IC50: 160 nM	+++ p110δ, IC50: 10 nM				99%+
Duvelisib			++++ PI3Kβ, Ki: 1564 pM	++ PI3Kγ, Ki: 243 pM	++++ PI3Kδ, Ki: 23 pM				99%+
GDC-0326		++++ PI3Kα, Ki: 0.2 nM	++ PI3Kβ, Ki: 26.6 nM	+++ PI3Kγ, Ki: 10.2 nM	++++ PI3Kδ, Ki: 4 nM				98%
Quercetin Dihydrate			+ PI3Kβ, IC50: 5.4 μM	+ PI3Kγ, IC50: 2.4 μM	+ PI3Kδ, IC50: 3.0 μM				95%
Quercetin			+ PI3Kβ, IC50: 5.4 μM	+ PI3Kγ, IC50: 2.4 μM	+ PI3Kδ, IC50: 3.0 μM			PKC,Src,Sirtuin	95%
Leniolisib		+ PI3Kα, IC50: 0.244 μM	+ PI3Kβ, IC50: 0.424 μM	+ PI3Kγ, IC50: 2.23 μM	+++ PI3Kδ, IC50: 0.011 μM			DNA-PK	99%+
PIK-108			✔						99%
Eganelisib				+++ PI3Kγ, IC50: 16 nM					99%+
CAY10505				✔					99%
IPI-3063					++++ p110δ, IC50: 2.5 nM				99%
Nemiralisib					++++ PI3Kδ, pKi: 9.9				99%+
PF-4989216		++++ p110α, IC50: 2 nM		++ p110γ, IC50: 65 nM	++++ p110δ, IC50: 1 nM				99%+
PIK-75 HCl		+++ p110α, IC50: 5.8 nM		++ p110γ, IC50: 76 nM	+ p110δ, IC50: 0.51 μM			DNA-PK	99%+
Tenalisib				++ PI3Kγ, IC50: 33.2 nM	++ PI3Kδ, IC50: 24.5 nM				98%
Acalisib					+++ p110δ, IC50: 14 nM				99%+
Umbralisib					+++ PI3Kδ, IC50: 22.2 nM				99%+
AMG319				+ PI3Kγ, IC50: 850 nM	+++ PI3Kδ, IC50: 18 nM				99%
IC-87114				+ PI3Kγ, IC50: 29 μM	+ PI3Kδ, IC50: 0.5 μM				99%+
Idelalisib				++ p110γ, IC50: 89 nM	++++ p110δ, IC50: 2.5 nM				98%
PIK-293				+ p110γ, IC50: 10 μM	+ p110δ, IC50: 0.24 μM				99%+
Vps34-PIK-III					+ PI3Kδ, IC50: 1.2μM		+++ Vps34, IC50: 0.018μM		99%+
GSK2292767					✔				98%
Seletalisib				+ PI3Kγ, IC50: 282 nM	+++ PI3Kδ, IC50: 12 nM				99%+
P110δ-IN-1					++++ P110δ, IC50: 0.6 nM				99%
PI3Kδ-IN-5					++++ PI3Kδ, IC50: 0.9 nM				99%
SRX3207		+ PI3K alpha, IC50: 244 nM		+ PI3K gamma, IC50: 9790 nM	+ PI3K delta, IC50: 388 nM			Syk	98%
Parsaclisib HCl					++++ PI3Kδ, IC50: 1 nM				98%
IHMT-PI3Kδ-372					+++ PI3Kδ, IC50: 14 nM				98%
Trigonelline						✔		Akt	99%+
Wortmannin						++++ PI3K, IC50: 3 nM		MLCK,DNA-PK	99%+
Samotolisib						✔		DNA-PK	99%+
GNE-317						✔			99%+
Oroxin B						✔		PTEN,Akt	99%+
NU 7026						+ PI3K, IC50: 13 μM		DNA-PK	98+%
Deguelin						✔		Akt	99%+
Ailanthone						✔		Akt,ATM/ATR,CDK	98%
Resibufogenin						✔		ROS	98%
KU-57788						+ PI3K, IC50: 5 μM		mTOR,DNA-PK	99%+
Cinobufagine						✔		Akt	99%
α-Linolenic acid						✔			97% (GC)
MTX-211						✔		EGFR	98%
PI3K/mTOR Inhibitor-2						++++ PI3K, IC50: 3.4 nM		mTOR	99%+
SPP-86						✔			99%+
(E)-Akt inhibitor-IV						✔			98%
Vps34-IN-1							++ Vps34, IC50: 25 nM		98%
SAR405							++++ Vps34, IC50: 1.2 nM		98+%
3-Methyladenine				+ PI3Kγ, IC50: 60 μM			+ Vps34, IC50: 25 μM	Autophagy	98%
Vps34-IN-4							+++ VPS34, IC50: 15 nM		98%+
Autophinib							+++ Vps34, IC50: 19 nM	Autophagy	99%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

KU-57788 生物活性

靶点

PI3K

PI3K, IC50:5 μM
DNA-PK

DNA-PK, IC50:14 nM

描述

NU7441 increases the persistence of γH2AX foci after ionizing radiation–induced or etoposide-induced DNA damage. NU7441 (0.5 μM or 1 μM) appreciably increases G2-M accumulation induced by ionizing radiation, etoposide, and doxorubicin in both SW620 and LoVo cells. NU7441 causes persistence of doxorubicin- and ionising radiation-induced DNA double-strand break and also slightly decreases homologous recombination activity DNA-PK-proficient M059-Fus-1 and DNA-PK-deficient M059 J human tumour cells. NU7441 inhibits UV-induced RPA p34 hyperphosphorylation in a dose-dependent manner both in cells lacking and cells expressing polymerase η. NU7441 increases levels of fludarabine-induced γH2AX foci and correspondingly decreased fludarabine-induced cell death in chronic lymphocytic leukemia cells. NU7441 also inhibits mitoxantrone-induced DNA-PKcs autophosphorylation and repair in chronic lymphocytic leukemia cells. It reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage.

KU-57788 细胞实验

Cell Line SLK cells HDMVEC cells GBM cells SAS cells U2OS cells	Concentration	Treated Time	Description	References
SLK cells	15 μM	2 h	To evaluate the effect of KU-57788 on KSHV circularization in SLK cells. Results showed that KU-57788 significantly reduced KSHV circularization efficiency.	Nucleic Acids Res. 2024 Feb 28;52(4):1814-1829.
HDMVEC cells	15 μM	2 h	To evaluate the effect of KU-57788 on KSHV circularization in HDMVEC cells. Results showed that KU-57788 significantly reduced KSHV circularization efficiency.	Nucleic Acids Res. 2024 Feb 28;52(4):1814-1829.
GBM cells	1 μM		KU-57788 inhibited the activation of DNA-PKcs, reducing TMZ-induced DNA damage repair, thereby enhancing the cytotoxicity of TMZ on GBM cells.	Cell Res. 2021 Oct;31(10):1072-1087.
SAS cells	5 μM	1 h	Inhibited NHEJ repair of radiation-induced DSBs, TGF β inhibition partially rescued the repair	Sci Transl Med. 2021 Feb 10;13(580):eabc4465.
U2OS cells	2 μM	2 h	To inhibit DNA-PK activity and study its effect on the induction of pUbT12 foci	Mol Cell. 2020 Nov 5;80(3):423-436.e9.

KU-57788 动物实验

Species Mice	Animal Model Ovarian cancer peritoneal metastasis model	Administration	Dosage	Frequency	Description	References
Mice	Ovarian cancer peritoneal metastasis model	Oral	60 mg/kg	Once daily for 21 days	To evaluate the in vivo efficacy of HIPET combined with WEE1 inhibitor	Nat Commun. 2024 Mar 7;15(1):2089

KU-57788 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.42mL

0.48mL

0.24mL

12.09mL

2.42mL

1.21mL

24.18mL

4.84mL

2.42mL

KU-57788 技术信息

CAS号	503468-95-9
分子式	C₂₅H₁₉NO₃S
分子量	413.49
SMILES Code	O=C1C=C(N2CCOCC2)OC3=C(C4=C5C(C6=CC=CC=C6S5)=CC=C4)C=CC=C13
MDL No.	MFCD11983069

别名	NU7441
运输	蓝冰
InChI Key	JAMULYFATHSZJM-UHFFFAOYSA-N
Pubchem ID	11327430

存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Sealed in dry, store in freezer, under -20°C

溶解方案

细胞实验：

DMSO: 15 mg/mL(36.28 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验：请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用；以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

方案二

方案三

细胞研究

细胞系	浓度	检测类型	检测时间	活性说明	数据源

23132-87	Growth Inhibition Assay	IC50=5.32024 μM	SANGER
639-V	Growth Inhibition Assay	IC50=1.44128 μM	SANGER
647-V	Growth Inhibition Assay	IC50=15.2705 μM	SANGER
697	Growth Inhibition Assay	IC50=3.44993 μM	SANGER
786-0	Growth Inhibition Assay	IC50=7.09786 μM	SANGER
8305C	Growth Inhibition Assay	IC50=3.61736 μM	SANGER
8505C	Growth Inhibition Assay	IC50=25.1845 μM	SANGER
8-MG-BA	Growth Inhibition Assay	IC50=13.7513 μM	SANGER
A101D	Growth Inhibition Assay	IC50=2.61338 μM	SANGER
A172	Growth Inhibition Assay	IC50=0.15316 μM	SANGER
A204	Growth Inhibition Assay	IC50=18.5452 μM	SANGER
A2058	Growth Inhibition Assay	IC50=10.6404 μM	SANGER
A253	Growth Inhibition Assay	IC50=21.4481 μM	SANGER
A427	Growth Inhibition Assay	IC50=5.53661 μM	SANGER
A431	Growth Inhibition Assay	IC50=39.1894 μM	SANGER
A549	Growth Inhibition Assay	IC50=9.09612 μM	SANGER
A704	Growth Inhibition Assay	IC50=4.40888 μM	SANGER
ACN	Growth Inhibition Assay	IC50=7.7433 μM	SANGER
AGS	Growth Inhibition Assay	IC50=14.1319 μM	SANGER
ALL-PO	Growth Inhibition Assay	IC50=49.9268 μM	SANGER
AM-38	Growth Inhibition Assay	IC50=30.0606 μM	SANGER
AN3-CA	Growth Inhibition Assay	IC50=4.25813 μM	SANGER
AsPC-1	Growth Inhibition Assay	IC50=30.8053 μM	SANGER
AU565	Growth Inhibition Assay	IC50=7.59833 μM	SANGER
BALL-1	Growth Inhibition Assay	IC50=12.2662 μM	SANGER
BB30-HNC	Growth Inhibition Assay	IC50=25.2483 μM	SANGER
BB49-HNC	Growth Inhibition Assay	IC50=10.8586 μM	SANGER
BB65-RCC	Growth Inhibition Assay	IC50=23.7863 μM	SANGER
BCPAP	Growth Inhibition Assay	IC50=22.611 μM	SANGER
BE-13	Growth Inhibition Assay	IC50=21.6113 μM	SANGER
Becker	Growth Inhibition Assay	IC50=13.058 μM	SANGER
BFTC-905	Growth Inhibition Assay	IC50=2.16687 μM	SANGER
BFTC-909	Growth Inhibition Assay	IC50=14.5055 μM	SANGER
BHT-101	Growth Inhibition Assay	IC50=3.59985 μM	SANGER
BHY	Growth Inhibition Assay	IC50=32.9495 μM	SANGER
BPH-1	Growth Inhibition Assay	IC50=10.7145 μM	SANGER
BT-549	Growth Inhibition Assay	IC50=48.3729 μM	SANGER
C32	Growth Inhibition Assay	IC50=10.8347 μM	SANGER
C-33-A	Growth Inhibition Assay	IC50=32.7728 μM	SANGER
Ca9-22	Growth Inhibition Assay	IC50=29.4299 μM	SANGER
CAKI-1	Growth Inhibition Assay	IC50=9.1661 μM	SANGER
CAL-12T	Growth Inhibition Assay	IC50=7.94352 μM	SANGER
CAL-27	Growth Inhibition Assay	IC50=14.0727 μM	SANGER
CAL-51	Growth Inhibition Assay	IC50=4.24854 μM	SANGER
CAL-54	Growth Inhibition Assay	IC50=11.4811 μM	SANGER
CAL-62	Growth Inhibition Assay	IC50=47.4068 μM	SANGER
CAL-72	Growth Inhibition Assay	IC50=10.8094 μM	SANGER
CAPAN-1	Growth Inhibition Assay	IC50=7.24359 μM	SANGER
CaR-1	Growth Inhibition Assay	IC50=28.5582 μM	SANGER
CAS-1	Growth Inhibition Assay	IC50=44.0991 μM	SANGER
CGTH-W-1	Growth Inhibition Assay	IC50=23.0641 μM	SANGER
ChaGo-K-1	Growth Inhibition Assay	IC50=5.56599 μM	SANGER
CHL-1	Growth Inhibition Assay	IC50=1.21368 μM	SANGER
CHP-134	Growth Inhibition Assay	IC50=8.24185 μM	SANGER
CHP-212	Growth Inhibition Assay	IC50=28.7401 μM	SANGER
COLO-320-HSR	Growth Inhibition Assay	IC50=25.2208 μM	SANGER
COLO-679	Growth Inhibition Assay	IC50=11.946 μM	SANGER
COLO-684	Growth Inhibition Assay	IC50=11.7267 μM	SANGER
CP50-MEL-B	Growth Inhibition Assay	IC50=13.6232 μM	SANGER
CP66-MEL	Growth Inhibition Assay	IC50=48.0704 μM	SANGER
CTB-1	Growth Inhibition Assay	IC50=1.11546 μM	SANGER
CW-2	Growth Inhibition Assay	IC50=21.2705 μM	SANGER
D-263MG	Growth Inhibition Assay	IC50=6.91068 μM	SANGER
D-283MED	Growth Inhibition Assay	IC50=12.0569 μM	SANGER
D-336MG	Growth Inhibition Assay	IC50=19.9322 μM	SANGER
D-392MG	Growth Inhibition Assay	IC50=37.3344 μM	SANGER
D-423MG	Growth Inhibition Assay	IC50=1.69361 μM	SANGER
D-542MG	Growth Inhibition Assay	IC50=21.9069 μM	SANGER
D-566MG	Growth Inhibition Assay	IC50=14.7706 μM	SANGER
Daoy	Growth Inhibition Assay	IC50=32.0838 μM	SANGER
DB	Growth Inhibition Assay	IC50=24.1028 μM	SANGER
DBTRG-05MG	Growth Inhibition Assay	IC50=3.28085 μM	SANGER
DEL	Growth Inhibition Assay	IC50=2.35564 μM	SANGER
Detroit562	Growth Inhibition Assay	IC50=33.6657 μM	SANGER
DK-MG	Growth Inhibition Assay	IC50=27.1817 μM	SANGER
DMS-114	Growth Inhibition Assay	IC50=15.3291 μM	SANGER
DU-4475	Growth Inhibition Assay	IC50=9.96939 μM	SANGER
EFO-27	Growth Inhibition Assay	IC50=4.66525 μM	SANGER
EGI-1	Growth Inhibition Assay	IC50=16.5365 μM	SANGER
EKVX	Growth Inhibition Assay	IC50=4.22524 μM	SANGER
EM-2	Growth Inhibition Assay	IC50=10.2426 μM	SANGER
EPLC-272H	Growth Inhibition Assay	IC50=7.16246 μM	SANGER
ES1	Growth Inhibition Assay	IC50=29.8544 μM	SANGER
ES4	Growth Inhibition Assay	IC50=32.3922 μM	SANGER
ES5	Growth Inhibition Assay	IC50=13.1356 μM	SANGER
ES7	Growth Inhibition Assay	IC50=3.46729 μM	SANGER
ES8	Growth Inhibition Assay	IC50=6.97588 μM	SANGER
ETK-1	Growth Inhibition Assay	IC50=21.8152 μM	SANGER
EW-1	Growth Inhibition Assay	IC50=33.9322 μM	SANGER
EW-13	Growth Inhibition Assay	IC50=20.5443 μM	SANGER
EW-22	Growth Inhibition Assay	IC50=21.376 μM	SANGER
FADU	Growth Inhibition Assay	IC50=8.03654 μM	SANGER
FTC-133	Growth Inhibition Assay	IC50=12.0076 μM	SANGER
G-361	Growth Inhibition Assay	IC50=2.2168 μM	SANGER
G-401	Growth Inhibition Assay	IC50=10.7626 μM	SANGER
G-402	Growth Inhibition Assay	IC50=7.30051 μM	SANGER
GAMG	Growth Inhibition Assay	IC50=7.64131 μM	SANGER
GB-1	Growth Inhibition Assay	IC50=15.6437 μM	SANGER
GCIY	Growth Inhibition Assay	IC50=5.51378 μM	SANGER
GCT	Growth Inhibition Assay	IC50=39.1852 μM	SANGER
GI-ME-N	Growth Inhibition Assay	IC50=9.70137 μM	SANGER
GMS-10	Growth Inhibition Assay	IC50=10.8971 μM	SANGER
GOTO	Growth Inhibition Assay	IC50=3.9149 μM	SANGER
GT3TKB	Growth Inhibition Assay	IC50=12.3074 μM	SANGER
H4	Growth Inhibition Assay	IC50=47.6621 μM	SANGER
HAL-01	Growth Inhibition Assay	IC50=45.1379 μM	SANGER
HCC1806	Growth Inhibition Assay	IC50=19.1591 μM	SANGER
HCC1937	Growth Inhibition Assay	IC50=9.69865 μM	SANGER
HCC2157	Growth Inhibition Assay	IC50=21.36 μM	SANGER
HCC2998	Growth Inhibition Assay	IC50=26.0283 μM	SANGER
HCC70	Growth Inhibition Assay	IC50=5.03939 μM	SANGER
HCE-4	Growth Inhibition Assay	IC50=29.8786 μM	SANGER
HDLM-2	Growth Inhibition Assay	IC50=0.32345 μM	SANGER
HEC-1	Growth Inhibition Assay	IC50=20.4978 μM	SANGER
HH	Growth Inhibition Assay	IC50=1.18093 μM	SANGER
HL-60	Growth Inhibition Assay	IC50=1.3819 μM	SANGER
HLE	Growth Inhibition Assay	IC50=22.697 μM	SANGER
HMV-II	Growth Inhibition Assay	IC50=39.5047 μM	SANGER
HO-1-N-1	Growth Inhibition Assay	IC50=24.3093 μM	SANGER
HOP-62	Growth Inhibition Assay	IC50=11.7508 μM	SANGER
HOP-92	Growth Inhibition Assay	IC50=12.5233 μM	SANGER
HOS	Growth Inhibition Assay	IC50=8.37589 μM	SANGER
HPAF-II	Growth Inhibition Assay	IC50=21.8923 μM	SANGER
Hs-578-T	Growth Inhibition Assay	IC50=20.5583 μM	SANGER
HSC-2	Growth Inhibition Assay	IC50=5.41773 μM	SANGER
HSC-3	Growth Inhibition Assay	IC50=23.8527 μM	SANGER
HT	Growth Inhibition Assay	IC50=8.3649 μM	SANGER
HT-1080	Growth Inhibition Assay	IC50=8.25093 μM	SANGER
HT-1376	Growth Inhibition Assay	IC50=16.8446 μM	SANGER
HT-144	Growth Inhibition Assay	IC50=18.7427 μM	SANGER
HT-3	Growth Inhibition Assay	IC50=38.4436 μM	SANGER
HTC-C3	Growth Inhibition Assay	IC50=11.0714 μM	SANGER
HuCCT1	Growth Inhibition Assay	IC50=42.5289 μM	SANGER
HuH-7	Growth Inhibition Assay	IC50=2.56702 μM	SANGER
HuO-3N1	Growth Inhibition Assay	IC50=0.46636 μM	SANGER
HuO9	Growth Inhibition Assay	IC50=7.71743 μM	SANGER
HuP-T4	Growth Inhibition Assay	IC50=30.9638 μM	SANGER
IA-LM	Growth Inhibition Assay	IC50=4.27935 μM	SANGER
IGR-1	Growth Inhibition Assay	IC50=48.6645 μM	SANGER
IGROV-1	Growth Inhibition Assay	IC50=5.25292 μM	SANGER
IST-MEL1	Growth Inhibition Assay	IC50=4.58263 μM	SANGER
IST-MES1	Growth Inhibition Assay	IC50=40.1502 μM	SANGER
IST-SL1	Growth Inhibition Assay	IC50=6.69369 μM	SANGER
J-RT3-T3-5	Growth Inhibition Assay	IC50=6.63291 μM	SANGER
JVM-3	Growth Inhibition Assay	IC50=3.48077 μM	SANGER
K5	Growth Inhibition Assay	IC50=10.9071 μM	SANGER
K-562	Growth Inhibition Assay	IC50=19.8926 μM	SANGER
KALS-1	Growth Inhibition Assay	IC50=2.69633 μM	SANGER
KARPAS-299	Growth Inhibition Assay	IC50=7.32622 μM	SANGER
KG-1	Growth Inhibition Assay	IC50=2.67924 μM	SANGER
KGN	Growth Inhibition Assay	IC50=16.5586 μM	SANGER
KINGS-1	Growth Inhibition Assay	IC50=21.6316 μM	SANGER
KM12	Growth Inhibition Assay	IC50=25.5807 μM	SANGER
KM-H2	Growth Inhibition Assay	IC50=36.4743 μM	SANGER
KNS-62	Growth Inhibition Assay	IC50=8.37762 μM	SANGER
KNS-81-FD	Growth Inhibition Assay	IC50=32.0128 μM	SANGER
KP-N-YN	Growth Inhibition Assay	IC50=27.8043 μM	SANGER
KP-N-YS	Growth Inhibition Assay	IC50=1.14231 μM	SANGER
KU-19-19	Growth Inhibition Assay	IC50=4.32921 μM	SANGER
KURAMOCHI	Growth Inhibition Assay	IC50=15.971 μM	SANGER
KYSE-150	Growth Inhibition Assay	IC50=47.1052 μM	SANGER
KYSE-410	Growth Inhibition Assay	IC50=5.47636 μM	SANGER
KYSE-450	Growth Inhibition Assay	IC50=28.8091 μM	SANGER
KYSE-510	Growth Inhibition Assay	IC50=43.1754 μM	SANGER
L-363	Growth Inhibition Assay	IC50=4.77116 μM	SANGER
LAMA-84	Growth Inhibition Assay	IC50=0.98833 μM	SANGER
LAN-6	Growth Inhibition Assay	IC50=21.0396 μM	SANGER
LB1047-RCC	Growth Inhibition Assay	IC50=6.17522 μM	SANGER
LB2241-RCC	Growth Inhibition Assay	IC50=2.14146 μM	SANGER
LB2518-MEL	Growth Inhibition Assay	IC50=31.0744 μM	SANGER
LB373-MEL-D	Growth Inhibition Assay	IC50=27.1294 μM	SANGER
LB996-RCC	Growth Inhibition Assay	IC50=11.0723 μM	SANGER
LCLC-103H	Growth Inhibition Assay	IC50=44.8703 μM	SANGER
LCLC-97TM1	Growth Inhibition Assay	IC50=8.21122 μM	SANGER
LNCaP-Clone-FGC	Growth Inhibition Assay	IC50=17.5201 μM	SANGER
LoVo	Growth Inhibition Assay	IC50=0.86749 μM	SANGER
LOXIMVI	Growth Inhibition Assay	IC50=15.8919 μM	SANGER
LU-134-A	Growth Inhibition Assay	IC50=4.59685 μM	SANGER
LXF-289	Growth Inhibition Assay	IC50=3.91041 μM	SANGER
M14	Growth Inhibition Assay	IC50=13.0335 μM	SANGER
MDA-MB-157	Growth Inhibition Assay	IC50=40.9462 μM	SANGER
MDA-MB-361	Growth Inhibition Assay	IC50=19.0714 μM	SANGER
MDA-MB-415	Growth Inhibition Assay	IC50=5.00314 μM	SANGER
ME-180	Growth Inhibition Assay	IC50=15.4783 μM	SANGER
MEL-HO	Growth Inhibition Assay	IC50=4.77989 μM	SANGER
MG-63	Growth Inhibition Assay	IC50=3.62676 μM	SANGER
MHH-ES-1	Growth Inhibition Assay	IC50=32.4872 μM	SANGER
MHH-NB-11	Growth Inhibition Assay	IC50=6.32721 μM	SANGER
MHH-PREB-1	Growth Inhibition Assay	IC50=2.16609 μM	SANGER
MIA-PaCa-2	Growth Inhibition Assay	IC50=7.36823 μM	SANGER
MKN1	Growth Inhibition Assay	IC50=24.68 μM	SANGER
MKN7	Growth Inhibition Assay	IC50=28.5964 μM	SANGER
MLMA	Growth Inhibition Assay	IC50=5.83606 μM	SANGER
MN-60	Growth Inhibition Assay	IC50=24.8519 μM	SANGER
MOLT-4	Growth Inhibition Assay	IC50=2.21888 μM	SANGER
Mo-T	Growth Inhibition Assay	IC50=48.279 μM	SANGER
MS-1	Growth Inhibition Assay	IC50=15.5623 μM	SANGER
MV-4-11	Growth Inhibition Assay	IC50=2.3739 μM	SANGER
MZ2-MEL	Growth Inhibition Assay	IC50=14.1488 μM	SANGER
MZ7-mel	Growth Inhibition Assay	IC50=15.1067 μM	SANGER
NB10	Growth Inhibition Assay	IC50=26.234 μM	SANGER
NB13	Growth Inhibition Assay	IC50=25.5898 μM	SANGER
NB14	Growth Inhibition Assay	IC50=6.79761 μM	SANGER
NB5	Growth Inhibition Assay	IC50=10.7559 μM	SANGER
NB69	Growth Inhibition Assay	IC50=5.3242 μM	SANGER
NB7	Growth Inhibition Assay	IC50=1.24745 μM	SANGER
NBsusSR	Growth Inhibition Assay	IC50=6.82502 μM	SANGER
NCI-H1048	Growth Inhibition Assay	IC50=21.2258 μM	SANGER
NCI-H1092	Growth Inhibition Assay	IC50=13.7475 μM	SANGER
NCI-H1155	Growth Inhibition Assay	IC50=10.8376 μM	SANGER
NCI-H1299	Growth Inhibition Assay	IC50=48.7248 μM	SANGER
NCI-H1304	Growth Inhibition Assay	IC50=15.8928 μM	SANGER
NCI-H1355	Growth Inhibition Assay	IC50=5.296 μM	SANGER
NCI-H1395	Growth Inhibition Assay	IC50=34.0799 μM	SANGER
NCI-H1437	Growth Inhibition Assay	IC50=10.5725 μM	SANGER
NCI-H1563	Growth Inhibition Assay	IC50=11.1011 μM	SANGER
NCI-H1703	Growth Inhibition Assay	IC50=31.0905 μM	SANGER
NCI-H1755	Growth Inhibition Assay	IC50=10.2428 μM	SANGER
NCI-H1770	Growth Inhibition Assay	IC50=0.02143 μM	SANGER
NCI-H1793	Growth Inhibition Assay	IC50=1.4584 μM	SANGER
NCI-H2030	Growth Inhibition Assay	IC50=13.2062 μM	SANGER
NCI-H2228	Growth Inhibition Assay	IC50=31.4651 μM	SANGER
NCI-H2291	Growth Inhibition Assay	IC50=18.4345 μM	SANGER
NCI-H2347	Growth Inhibition Assay	IC50=6.93213 μM	SANGER
NCI-H2452	Growth Inhibition Assay	IC50=21.8647 μM	SANGER
NCI-H28	Growth Inhibition Assay	IC50=8.16962 μM	SANGER
NCI-H292	Growth Inhibition Assay	IC50=1.74013 μM	SANGER
NCI-H358	Growth Inhibition Assay	IC50=44.0304 μM	SANGER
NCI-H520	Growth Inhibition Assay	IC50=36.7541 μM	SANGER
NCI-H522	Growth Inhibition Assay	IC50=22.8431 μM	SANGER
NCI-H526	Growth Inhibition Assay	IC50=0.28407 μM	SANGER
NCI-H596	Growth Inhibition Assay	IC50=19.6391 μM	SANGER
NCI-H630	Growth Inhibition Assay	IC50=22.0296 μM	SANGER
NCI-H650	Growth Inhibition Assay	IC50=11.8961 μM	SANGER
NCI-H727	Growth Inhibition Assay	IC50=22.735 μM	SANGER
NCI-H82	Growth Inhibition Assay	IC50=7.26659 μM	SANGER
NCI-SNU-1	Growth Inhibition Assay	IC50=0.60994 μM	SANGER
NEC8	Growth Inhibition Assay	IC50=1.5535 μM	SANGER
NKM-1	Growth Inhibition Assay	IC50=7.74955 μM	SANGER
NOMO-1	Growth Inhibition Assay	IC50=37.8089 μM	SANGER
NOS-1	Growth Inhibition Assay	IC50=3.65312 μM	SANGER
NTERA-S-cl-D1	Growth Inhibition Assay	IC50=32.0739 μM	SANGER
NUGC-3	Growth Inhibition Assay	IC50=15.6245 μM	SANGER
NY	Growth Inhibition Assay	IC50=3.45022 μM	SANGER
OAW-42	Growth Inhibition Assay	IC50=8.95964 μM	SANGER
OE33	Growth Inhibition Assay	IC50=47.1429 μM	SANGER
OS-RC-2	Growth Inhibition Assay	IC50=11.0559 μM	SANGER
OVCAR-4	Growth Inhibition Assay	IC50=7.31328 μM	SANGER
OVCAR-8	Growth Inhibition Assay	IC50=45.3564 μM	SANGER
P12-ICHIKAWA	Growth Inhibition Assay	IC50=44.6112 μM	SANGER
P30-OHK	Growth Inhibition Assay	IC50=29.3048 μM	SANGER
PA-1	Growth Inhibition Assay	IC50=1.58294 μM	SANGER
PANC-03-27	Growth Inhibition Assay	IC50=16.7662 μM	SANGER
PANC-08-13	Growth Inhibition Assay	IC50=3.41278 μM	SANGER
PC-3	Growth Inhibition Assay	IC50=8.27392 μM	SANGER
PFSK-1	Growth Inhibition Assay	IC50=5.62194 μM	SANGER
QIMR-WIL	Growth Inhibition Assay	IC50=3.41341 μM	SANGER
Ramos-2G6-4C10	Growth Inhibition Assay	IC50=2.19909 μM	SANGER
RCC10RGB	Growth Inhibition Assay	IC50=20.6719 μM	SANGER
RD	Growth Inhibition Assay	IC50=22.7518 μM	SANGER
RH-1	Growth Inhibition Assay	IC50=16.825 μM	SANGER
RH-18	Growth Inhibition Assay	IC50=4.44953 μM	SANGER
RMG-I	Growth Inhibition Assay	IC50=27.2029 μM	SANGER
RO82-W-1	Growth Inhibition Assay	IC50=7.74533 μM	SANGER
RPMI-7951	Growth Inhibition Assay	IC50=28.2456 μM	SANGER
RPMI-8226	Growth Inhibition Assay	IC50=38.9519 μM	SANGER
RPMI-8866	Growth Inhibition Assay	IC50=17.0699 μM	SANGER
RS4-11	Growth Inhibition Assay	IC50=2.56023 μM	SANGER
RT-112	Growth Inhibition Assay	IC50=29.4611 μM	SANGER
RVH-421	Growth Inhibition Assay	IC50=6.07338 μM	SANGER
RXF393	Growth Inhibition Assay	IC50=29.2906 μM	SANGER
SCC-4	Growth Inhibition Assay	IC50=31.9181 μM	SANGER
SF126	Growth Inhibition Assay	IC50=4.60715 μM	SANGER
SF295	Growth Inhibition Assay	IC50=40.8066 μM	SANGER
SJSA-1	Growth Inhibition Assay	IC50=20.5688 μM	SANGER
SKG-IIIa	Growth Inhibition Assay	IC50=13.0554 μM	SANGER
SK-LMS-1	Growth Inhibition Assay	IC50=27.0704 μM	SANGER
SK-LU-1	Growth Inhibition Assay	IC50=23.4683 μM	SANGER
SK-MEL-1	Growth Inhibition Assay	IC50=1.79479 μM	SANGER
SK-MEL-2	Growth Inhibition Assay	IC50=20.1559 μM	SANGER
SK-MEL-28	Growth Inhibition Assay	IC50=10.8202 μM	SANGER
SK-MEL-3	Growth Inhibition Assay	IC50=2.1649 μM	SANGER
SK-MEL-30	Growth Inhibition Assay	IC50=3.42598 μM	SANGER
SK-MES-1	Growth Inhibition Assay	IC50=24.0161 μM	SANGER
SK-N-AS	Growth Inhibition Assay	IC50=0.62216 μM	SANGER
SK-NEP-1	Growth Inhibition Assay	IC50=2.38783 μM	SANGER
SK-OV-3	Growth Inhibition Assay	IC50=27.7593 μM	SANGER
SK-PN-DW	Growth Inhibition Assay	IC50=12.1902 μM	SANGER
SK-UT-1	Growth Inhibition Assay	IC50=3.1531 μM	SANGER
SN12C	Growth Inhibition Assay	IC50=4.71898 μM	SANGER
SNB75	Growth Inhibition Assay	IC50=48.1874 μM	SANGER
SNU-423	Growth Inhibition Assay	IC50=13.381 μM	SANGER
SNU-449	Growth Inhibition Assay	IC50=8.2793 μM	SANGER
SNU-C2B	Growth Inhibition Assay	IC50=44.7903 μM	SANGER
SW1088	Growth Inhibition Assay	IC50=27.5042 μM	SANGER
SW13	Growth Inhibition Assay	IC50=40.519 μM	SANGER
SW1573	Growth Inhibition Assay	IC50=27.11 μM	SANGER
SW1783	Growth Inhibition Assay	IC50=16.0993 μM	SANGER
SW684	Growth Inhibition Assay	IC50=17.0154 μM	SANGER
SW900	Growth Inhibition Assay	IC50=44.0758 μM	SANGER
SW962	Growth Inhibition Assay	IC50=3.20352 μM	SANGER
SW982	Growth Inhibition Assay	IC50=7.30203 μM	SANGER
T47D	Growth Inhibition Assay	IC50=18.488 μM	SANGER
TCCSUP	Growth Inhibition Assay	IC50=47.6264 μM	SANGER
TE-1	Growth Inhibition Assay	IC50=41.8714 μM	SANGER
TE-11	Growth Inhibition Assay	IC50=11.9315 μM	SANGER
TE-12	Growth Inhibition Assay	IC50=39.2448 μM	SANGER
TE-5	Growth Inhibition Assay	IC50=15.2333 μM	SANGER
TE-6	Growth Inhibition Assay	IC50=38.124 μM	SANGER
TE-8	Growth Inhibition Assay	IC50=44.5658 μM	SANGER
TE-9	Growth Inhibition Assay	IC50=30.8737 μM	SANGER
TGBC11TKB	Growth Inhibition Assay	IC50=22.049 μM	SANGER
TI-73	Growth Inhibition Assay	IC50=16.9408 μM	SANGER
TK10	Growth Inhibition Assay	IC50=17.0079 μM	SANGER
TYK-nu	Growth Inhibition Assay	IC50=4.80128 μM	SANGER
U031	Growth Inhibition Assay	IC50=3.59368 μM	SANGER
U-118-MG	Growth Inhibition Assay	IC50=26.0808 μM	SANGER
U251	Growth Inhibition Assay	IC50=39.0124 μM	SANGER
U-87-MG	Growth Inhibition Assay	IC50=45.1022 μM	SANGER
UM-UC-3	Growth Inhibition Assay	IC50=6.64334 μM	SANGER
VA-ES-BJ	Growth Inhibition Assay	IC50=8.34686 μM	SANGER
VM-CUB-1	Growth Inhibition Assay	IC50=10.6164 μM	SANGER
VMRC-RCZ	Growth Inhibition Assay	IC50=2.77328 μM	SANGER
WM-115	Growth Inhibition Assay	IC50=11.6824 μM	SANGER
YH-13	Growth Inhibition Assay	IC50=3.87189 μM	SANGER
YKG-1	Growth Inhibition Assay	IC50=44.781 μM	SANGER
ZR-75-30	Growth Inhibition Assay	IC50=16.9361 μM	SANGER

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