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/ Resveratrol/白藜芦醇

Resveratrol/白藜芦醇 {[allProObj[0].p_purity_real_show]}

货号：A419526 同义名： trans-Resveratrol; SRT501

Resveratrol是一种多酚化合物，广泛存在于植物中，具有抗氧化、抗炎、抗癌和心血管保护特性。其靶点包括 mTOR、JAK、Nrf2、DNA 聚合酶和 β-淀粉样蛋白，IC50 值分别为 0.8 μM、1 μM、3.3 μM 和 5 μM。Resveratrol 可通过激活 SIRT1 和抑制 NF-κB 改善炎症与衰老相关疾病，并显示出促进一氧化氮 (NO) 产生的潜力。

Resveratrol/白藜芦醇 化学结构 CAS号：501-36-0
Resveratrol/白藜芦醇 化学结构
CAS号：501-36-0
Resveratrol/白藜芦醇 3D分子结构
CAS号：501-36-0
Resveratrol/白藜芦醇 化学结构 CAS号：501-36-0
Resveratrol/白藜芦醇 3D分子结构 CAS号：501-36-0
规格 价格 会员价 库存 数量
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Resveratrol/白藜芦醇 纯度/质量文件 产品仅供科研

货号：A419526 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]
• Cell, 2025. Ambeed. [ A122167 ]
• Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]
• Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]
• Nat. Nanotechnol., 2025. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]
更多 >
产品名称 DNA synthesis ↓ helicase ↓ RdRp ↓ ribonucleotide reductase ↓ tRNA synthetase ↓ YB-1 ↓ 其他靶点 纯度
Fexinidazole ✔ 98%
Daptomycin ✔ 98%
Blasticidin S·HCl ✔ 98%
Metronidazole ✔ 98%
Daunorubicin HCl +++

DNA synthesis, Ki: 20 nM

 		98%
Triglycidyl isocyanurate ✔ p53 98+%
Nedaplatin ✔ 99%+
Oxolinic acid ✔ 98+%
Bendamustine ✔ 98+%
Trifluridine ✔ 98%
Robinetin ✔ 99%+
Carboplatin ✔ 99%
Cidofovir ✔ 99%
Cisplatin ✔ 99%
Cytarabine ++++

DNA synthesis, IC50: 16 nM

 		98%
Acelarin ++++

DNA synthesis, EC50: 0.2 nM

 		99%+
Oxaliplatin ✔ 98%
YK-4-279 ✔ 99%+
ML216 +

BLMfull-length, IC50: 2.98 μM

BLM636-1298, IC50: 0.97 μM

 		99%+
RK-33 ✔ 98%
Brr2-IN-3 ✔ 99%+
Phen-DC3 Trifluoromethanesulfonate ✔ 95%
Favipiravir ✔ 99%
Suramin sodium salt ++

RdRp, IC50: 0.26 μM

 		99%+
Clofarabine ++

Ribonucleotide reductase, IC50: 65 nM

 		97%
Didox ✔ 98%
(E)-3-AP ✔ 99%
Halofuginone +++

prolyl-tRNA synthetase, Ki: 18.3nM

 		99%+
BC-LI-0186 +++

Leucyl-tRNA synthetase, Kd: 42.1 nM

Leucyl-tRNA synthetase, IC50: 46.11 nM

 		98%
SU056 +

YB-1, IC50: 1.73 μM

 		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
产品名称 AC ↓ EPAC1 ↓ EPAC2 ↓ PACAP receptor ↓ 其他靶点 纯度
Bithionol +

sAC, IC50: 4.0 μM

 		98%
SQ22536 ✔ 99%+
ESI-09 ++

EPAC1, IC50: 3.2 μM

 		+++

EPAC2, IC50: 1.4 μM

 		98%
HJC0350 +++

EPAC2, IC50: 0.3 μM

 		99%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
产品名称 NF-κB ↓ 其他靶点 纯度
Ammonium pyrrolidine-1-carbodithioate ✔ 98%
QNZ ++++

NF-κB, IC50: 11 nM

 		99%+
Sodium 4-Aminosalicylate Dihydrate ✔ 98%
Sodium Salicylate ✔ 95%
Parthenolide ✔ p53 97% HPLC
JSH-23 +

NF-κB, IC50: 7.1 μM

 		98%
Phenethyl caffeate ✔ 98%
Andrographolide ✔ 98+%
Curcumin ✔ Nrf2,HDAC 98%
SC75741 +++

NF-κB, EC50: 200 nM

 		99%+
CBL0137 HCl ++

NF-κB, EC50: 0.47 μM

 		p53 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Resveratrol/白藜芦醇 生物活性

靶点

  • SIRT1

  • JNK1

    JNK1, IC50:50 μM
描述 Resveratrol inhibits the activity of Cyclooxygenase, lipooxygenase, PKCs and p56, ERK1, JNK1, p38, IKK β, Src, STAT3, Ribonucleotide Reductase, DNA polymerases α and δ, PKD, PKC α, Quinone reductase 2, and Aromatase with IC50 of 0.035-60 μM. Resveratrol is also an activator of Adenylyl cyclase and AMPK with EC50 of 0.8 μM and 50 μM, respectively. The roles of Resveratrol as inhibitor or activator enable its effects on decreasing cell inflammatory associated behaviors, growth inhibition and induction of apoptosis in cancer cells, reversal of endothelin-1 stimulated cell responses, inhibition of phorbol ester-induced expression of COX-2, inhibition of DNA synthesis in cell, resistance to menadione-induced cell death, and improvement of cell mitochondrial function and glucose/lipid metabolism.
Resveratrol is also an activator of sirtuins. Resveratrol lowers the Michaelis constant of SIRT1 for both the acetylated substrate and NAD, and increases cell survival by stimulating SIRT1-dependent deacetylation of p53. In yeast, Resveratrol mimics calorie restriction by stimulating Sir2, increasing DNA stability and extending lifespan.
Resveratrol is effective at protecting isolated rat hearts against ischemia/reperfusion injury via its antioxidant activity, with improved recovery of developed pressure and aortic flow, reduction of malondialdehyde concentrations and reduction of infarct size.[1][2]

Resveratrol/白藜芦醇 细胞实验

Cell Line
Concentration Treated Time Description References
H460 0-200 μM 24 hours Evaluate the effect of YI-12 on H460 cell viability, showing an IC50 value of 107.9 ± 10.28 μM. Chem Res Toxicol. 2025 Mar 17;38(3):415-432.
A549 0-200 μM 24 hours Evaluate the effect of YI-12 on A549 cell viability, showing an IC50 value of 96.9 ± 8.95 μM. Chem Res Toxicol. 2025 Mar 17;38(3):415-432.
Caco-2 cells 1, 5, 25 µM To observe the inhibitory effect of Resveratrol on SR-B1 and NF-κB-p65, results showed that Resveratrol did not repress SR-B1 or NF-κB-p65 expression in Caco-2 cells. Nat Commun. 2023 May 9;14(1):2656.
Neonatal mouse cardiomyocytes 10 μM 30 min To investigate the protective effects of resveratrol on OGD/R-induced cardiomyocyte apoptosis. Results showed that resveratrol significantly inhibited OGD/R-induced cell apoptosis and LDH leakage. Cardiovasc Diabetol. 2014 Feb 5;13:35.
ectopic endometrial stroma cells (EcESCs) 25 and 50 µM 12 and 24 h inhibited the proliferation, migration, and invasion of endometrial stromal cells Mol Ther Methods Clin Dev. 2020 Sep 28;19:295-306.
Ishikawa cells 25 and 50 µM 24 and 48 h inhibited the migration and invasion of Ishikawa cells Mol Ther Methods Clin Dev. 2020 Sep 28;19:295-306.
H9C2 cells 25 µM 12 h To investigate the ameliorative effect of Resveratrol on autophagic flux under oxidative stress, the results showed that Resveratrol improved autophagic flux and reduced apoptosis in H9C2 cells through a SIRT1-dependent pathway. J Cell Mol Med. 2014 Aug;18(8):1599-611.
SH-SY5Y cells 10 μM 48 h Resveratrol significantly rescued cell survival in OGD-treated SH-SY5Y cells and reduced inflammation and oxidative stress through AMPK signaling. Int J Mol Sci. 2022 Oct 2;23(19):11678.
MCF-7 breast cancer cells 10 μM 7 days To assess the effect of resveratrol on MCF-7 cell proliferation, cells in steroid-depleted media were treated for 7 days with several ER ligands including resveratrol. Unlike E2, resveratrol did not stimulate cell proliferation. Elife. 2014 Apr 25;3:e02057.
HEK293-T cells 10 μM 24 h To evaluate the interaction of Resveratrol with ERα and coactivators SRC1-3 using a mammalian two-hybrid assay, results showed that Resveratrol induced full association of ERα with SRC2, but reduced interaction with SRC1 or SRC3. Elife. 2014 Apr 25;3:e02057.
C2C12 myotubes 50 μM, 100 μM 48 h Assess cytotoxicity, results showed that 50 and 100 μM of resveratrol did not exhibit significant cytotoxicity in C2C12 myotubes. Antioxidants (Basel). 2021 Feb 13;10(2):286.
C2C12 myotubes 50 μM, 100 μM 24 h Assess mitochondrial DNA gene expression, results showed that resveratrol significantly increased the expression of mitochondrial DNA genes in C2C12 myotubes. Antioxidants (Basel). 2021 Feb 13;10(2):286.
C2C12 myotubes 50 μM 24 h Assess mitochondrial content, results showed that resveratrol significantly increased the mitochondrial content in C2C12 myotubes. Antioxidants (Basel). 2021 Feb 13;10(2):286.

Resveratrol/白藜芦醇 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
Tibetan sheep Basal diet + RES (1.5 g/day) + HMB (1250 mg/day) Oral 1.5 g/day Daily for 90 days To investigate the role of DL-Serine in hepatic antioxidant capacity, immune response, and glycolytic activity. Results showed that DL-Serine was negatively correlated with the antioxidant index MDA and positively correlated with the glycolytic indices LDH, SDH, and MDH. Int J Mol Sci. 2024 Sep 12;25(18):9865
Mice High-fat diet-induced obesity model Diet 0.5% in diet 8 weeks To study the metabolic effects of Resveratrol in high-fat diet-induced obese mice, results showed that Resveratrol inhibited intestinal SR-B1 expression, reduced chylomicron secretion, and improved lipid metabolism. Nat Commun. 2023 May 9;14(1):2656.
Mice Pde6aD670G mutant mice Oral 120 mg/L Starting from postnatal day 0 until the end of the experiment To evaluate the neuroprotective effects of resveratrol on the retina of Pde6aD670G mice. The results showed that resveratrol did not have a significant effect on visual function. EBioMedicine. 2020 Feb;52:102636
Mice Ischemia/reperfusion injury model Intraperitoneal injection 10 mg/kg Single dose, 60 minutes To investigate the cardioprotective effects of resveratrol on ischemia/reperfusion injury. Results showed that resveratrol significantly reduced myocardial infarct size and decreased serum LDH and CK activity. Cardiovasc Diabetol. 2014 Feb 5;13:35.
Nude mice Endometriosis model Intraperitoneal injection 25 mg/kg Daily for 4 weeks Inhibited the growth of ectopic endometrium and the expression of MTA1 and ZEB2 Mol Ther Methods Clin Dev. 2020 Sep 28;19:295-306.
C57BL/6J mice Streptozotocin (STZ)-induced diabetic model Dietary administration 60 mg/kg and 300 mg/kg Once daily for 12 weeks To investigate the protective effect of Resveratrol on cardiac function in diabetic mice, the results showed that Resveratrol improved cardiac function, reduced myocardial hypertrophy and fibrosis, and alleviated oxidative stress and apoptosis by regulating autophagic flux. J Cell Mol Med. 2014 Aug;18(8):1599-611.

Resveratrol/白藜芦醇 动物研究

Dose Rat: 10 mg/kg, 100 mg/kg[7] (i.g.) Mice: 1 mg/kg - 5 mg/kg[7] (i.p.), 150 mg/kg[7] (p.o.) Nude Mice: 25 mg/kg[7] (i.p.)
Administration i.g., p.o., i.p.

Resveratrol/白藜芦醇 参考文献

[1]Pirola L, Frojdo S. Resveratrol: one molecule, many targets. IUBMB Life. 2008 May;60(5):323-32.

[2]Howitz KT, Bitterman KJ, et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 2003 Sep 11;425(6954):191-6.

[3]Zunino SJ, Storms DH, et al. Resveratrol given intraperitoneally does not inhibit the growth of high-risk t(4;11) acute lymphoblastic leukemia cells in a NOD/SCID mouse model. Int J Oncol. 2012;40(4):1277-84.

[4]Thirunavukkarasu M, Penumathsa SV, et al. Resveratrol alleviates cardiac dysfunction in streptozotocin-induced diabetes: Role of nitric oxide, thioredoxin, and heme oxygenase. Free Radic Biol Med. 2007;43(5):720-9.

[5]Harper CE, Cook LM, et al. Genistein and resveratrol, alone and in combination, suppress prostate cancer in SV-40 tag rats. Prostate. 2009;69(15):1668-82.

[6]Singh M, Parent S, et al. Resveratrol modulates the expression of PTGS2 and cellular proliferation in the normal rat endometrium in an AKT-dependent manner. Biol Reprod. 2011;84(5):1045-52.

Resveratrol/白藜芦醇 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.38mL

0.88mL

0.44mL

21.91mL

4.38mL

2.19mL

43.81mL

8.76mL

4.38mL

Resveratrol/白藜芦醇 技术信息

CAS号501-36-0
分子式C14H12O3
分子量 228.24
SMILES Code OC1=CC(/C=C/C2=CC=C(O)C=C2)=CC(O)=C1
MDL No. MFCD00133799
别名 trans-Resveratrol; SRT501; Vineatrol 20M; Resvida; CA1201; RM1812; (E)-Resveratrol
运输蓝冰
InChI Key LUKBXSAWLPMMSZ-OWOJBTEDSA-N
Pubchem ID 445154
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Inert atmosphere, store in freezer, under -20°C
溶解方案

DMSO: 105 mg/mL(460.04 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

无水乙醇: 45 mg/mL(197.16 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一
方案 二
方案 三
方案 四
方案 五
方案 六
方案 七
方案 八
配制的工作液建议现用现配，短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。
方案 一
方案 二

Tags: Resveratrol | trans-Resveratrol;SRT501;Vineatrol 20M.;Resvida;CA1201;RM1812;(E)-Resveratrol | Plant Standard | Cyclooxygenase (COX) | Cyclooxygenase (COX) Inhibitor | DNA/RNA Synthesis | NF-κB | IKK | cAMP | AmBeed-信号通路专用抑制剂 | Resveratrol/白藜芦醇 纯度/质量文件 | Resveratrol/白藜芦醇 亚型比较 | Resveratrol/白藜芦醇 生物活性 | Resveratrol/白藜芦醇 动物研究 | Resveratrol/白藜芦醇 参考文献 | Resveratrol/白藜芦醇 实验方案 | Resveratrol/白藜芦醇 技术信息

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