Bithionol/硫氯酚
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货号：A138799
同义名：
硫双二氯酚
/ CP 3438; Actamer
Bithionol是一种抗寄生虫药和可溶性腺苷酸环化酶抑制剂，IC50 为 4 μM，可用于抑制实体肿瘤生长以及细菌、真菌和原生动物感染的治疗。
Bithionol/硫氯酚 化学结构
Bithionol/硫氯酚 3D分子结构
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Bithionol/硫氯酚 纯度/质量文件 产品仅供科研
货号：A138799
标准纯度：
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Bithionol/硫氯酚 质控信息
Bithionol/硫氯酚 生物活性
靶点
描述
Bithionol is a potent sAC-specific inhibitor with IC50 value of 4μM[3] [4]
作用机制
Bithionol binds to the sAC-specific, allosteric binding site for the physiological activator. It induces rearrangements of substrate binding residues and of Arg176, a trigger between the active site and allosteric site.[3]
Bithionol/硫氯酚 动物研究
Dose
Horse: 5 mg/kg, 10 mg/kgEvaluation of Anthelmintic Efficacy of Bithionol Paste against Tapeworms Naturally Infected in Horses, by Fecal Examination and Necropsy[3] [4]
Administration
p.o.
Bithionol/硫氯酚 参考文献
[1] Kleinboelting S, Ramos-Espiritu L, et al. Bithionol Potently Inhibits Human Soluble Adenylyl Cyclase through Binding to the Allosteric Activator Site. J Biol Chem. 2016 Apr 29;291(18):9776-84.
[2] Jakobsen E, Lange SC, et al. The inhibitors of soluble adenylate cyclase 2-OHE, KH7, and bithionol compromise mitochondrial ATP production by distinct mechanisms. Biochem Pharmacol. 2018 Sep;155:92-101.
[3] Kleinboelting S, Ramos-Espiritu L, Buck H, Colis L, van den Heuvel J, Glickman JF, Levin LR, Buck J, Steegborn C. Bithionol Potently Inhibits Human Soluble Adenylyl Cyclase through Binding to the Allosteric Activator Site. J Biol Chem. 2016 Apr 29;291(18):9776-84. doi: 10.1074/jbc.M115.708255. Epub 2016 Mar 9. PMID: 26961873; PMCID: PMC4850313.
[4] Jakobsen E, Lange SC, Andersen JV, Desler C, Kihl HF, Hohnholt MC, Stridh MH, Rasmussen LJ, Waagepetersen HS, Bak LK. The inhibitors of soluble adenylate cyclase 2-OHE, KH7, and bithionol compromise mitochondrial ATP production by distinct mechanisms. Biochem Pharmacol. 2018 Sep;155:92-101. doi: 10.1016/j.bcp.2018.06.023. Epub 2018 Jun 22. PMID: 29940175.
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Bithionol/硫氯酚 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
2.81mL
0.56mL
0.28mL
14.04mL
2.81mL
1.40mL
28.09mL
5.62mL
2.81mL
Bithionol/硫氯酚 技术信息
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