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货号 产品名 纯度
A1061932 GS143

GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 sup­presses NF-κB activation and transcription of target genes and does not inhibit proteasome activity. GS143 has anti-asthma effect .

99%+
A261555 N-Benzoyl-L-leucine/N-苯甲酰-L-亮氨酸

98%
A178450 PS-1145

PS-1145 is an IkappaB kinase (IKK) inhibitor with IC50 of 88 nM.

99%+
A165589 TBK1/IKKε-IN-2

IKKε-IN-1 is a potent IKKε inhibitor. It inhibits the in-situ ΙKΚ ε-mediated phosphorylation of IRF3 with an IC50 value of less than about 100 nM.

98%+
A499215 SC-514

SC514 is a potent, reversible, ATP-competitive and highly selective IKK-β(IKK-2) inhibitor with IC50 value ranging in 3-12 µM.

98%
A493627 Dehydrocostus Lactone/去氢木香内酯

Dehydrocostus Lactone a naturally occuring sesquiterpene lactone in the roots of Saussurea lappa with anti-inflammatory activity.

99%+
A543661 ACHP HCl

ACHP HCl is a potent and selective IKK-2 inhibitor with IC50 of 8.5 nM.

99%+
A277907 MLN120B

MLN120B is a potent and effective IKKbeta inhibitor.

99%+
A724374 IMD-0560

99%+
A901193 BMS-345541 HCl

BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively.

99%+
A375644 BMS-345541

BMS-345541 dose-dependently inhibits the TNF-α-stimulated phosphorylation of IκBα in THP-1 monocytic cells with an IC50 of ~4 μM.

99%+
A377370 TPCA-1

TPCA-1 is a selective and potent IKK-β inhibitor with IC50 value of 17.9 nM.

99%+
A1177218 TBK1/IKKε-IN-5

QUN97653 is a dual TBK1 and IKKε inhibitor, with IC50 values of 1 nM and 5.6 nM for TBK1 and IKKε, respectively.

99%+
A165469 Bardoxolone/巴多索隆

Bardoxolone is a nuclear regulator factor (Nrf-2) activator.

98%+
A606355 WS3

WS3 is an Erb3 binding protein-1 (EBP1) and IκB kinase pathway modulator, it's a non-specific proliferative molecule and promotes β cell proliferation with EC50 of 28 nM.

99%+
A232738 IMD-0354

IMD-0354 is a synthetic selective NF-kB inhibitor and blocks IκBα phosphorylation in NF-κB pathway.

99%+
A608717 MRT67307

MRT67307 is a dual inhibitor of the IKKe and TBK-1.

99%+
A147089 LY2409881 3HCl

LY2409881 3HCl is a selective inhibitor of IKK2 with IC50 of 30 nM and IC50 for IKK1 and other common kinases is at least one log higher.

98+%
A142891 Bardoxolone methyl/甲基巴多索隆

Bardoxolone methyl is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities. It is also a potent Nrf2 activator and nuclear factor-κB (NF-κB) activator.

98%
A107077 BAY 11-7082

BAY 11-7082 is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM in tumor cells. It also inhibits components of the ubiquitin system through inactivating the E2-conjugating enzymes Ubc (ubiquitin conjugating) 13 and UbcH7 and the E3 ligase LUBAC (linear ubiquitin assembly complex).

98%
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