AZD8330 | ARRY-424704 | MEK Inhibitor | AmBeed-信号通路专用抑制剂

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AZD8330 {[allProObj[0].p_purity_real_show]}

货号：A473635 同义名： ARRY-424704; ARRY-704

AZD8330 is a selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM.

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

AZD8330 化学结构
CAS号：869357-68-6

AZD8330 3D分子结构
CAS号：869357-68-6

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AZD8330 纯度/质量文件产品仅供科研

货号：A473635 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]; • Cell, 2025. Ambeed. [ A122167 ]; • Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]; • Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]; • Nat. Nanotechnol., 2025. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]; 更多 >

MEK 亚型比较

产品名称	MEK ↓ ↑	MEK1 ↓ ↑	MEK1/2 ↓ ↑	MEK2 ↓ ↑	MEK5 ↓ ↑	其他靶点	纯度
Honokiol	✔						98%
Mirdametinib	++++ MEK, IC50: 0.33 nM						99%+
Binimetinib	+++ MEK, IC50: 12 nM						99%+
BI-847325		++ MEK1, IC50: 25 nM		+++ MEK2, IC50: 4 nM			99%+
U0126-EtOH		+ MEK1, IC50: 0.07 μM		++ MEK2, IC50: 0.06 μM			98%
GDC-0623		++++ MEK1, IC50: 0.13 nM					99%+
TAK-733		++++ MEK1, IC50: 3.2 nM					99%+
Trametinib		++++ MEK1, IC50: 0.92 nM		++++ MEK2, IC50: 1.8 nM			99%+
Selumetinib		+++ MEK1, IC50: 14 nM MEK1, Kd: 99 nM		+ MEK2, Kd: 530 nM			99%+
CI-1040		++ MEK1, IC50: 17 nM		++ MEK2, IC50: 17 nM			99%+
Myricetin		✔					98%
Refametinib		++ MEK1, IC50: 19 nM		++ MEK2, IC50: 47 nM			99%+
Cobimetinib		+++ MEK1, IC50: 4.2 nM					99%+
PD98059		+ MEK1, IC50: 2 μM					99%+
SL327		+ MEK1, IC50: 0.18 μM		+ MEK2, IC50: 0.22 μM		AP-1	98+%
PD318088			✔				99%
AZD8330			+++ MEK1/2, IC50: 7 nM				99%+
Pimasertib							98%
(E/Z)-BIX02189					++++ MEK5, IC50: 1.5 nM		99%+
(E/Z)-BIX02188					+++ MEK5, IC50: 4.3 nM		99%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

AZD8330 生物活性

靶点	MEK1/2 MEK1/2, IC50:7 nM
描述	AZD8330 is a selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM.

AZD8330 细胞实验

Cell Line Raji cells	Concentration	Treated Time	Description	References
Raji cells	50nM	24 h	To validate the inhibitory effect of AZD8330 on the Ras/MEK/ERK pathway, results showed that AZD8330 significantly inhibited the phosphorylation levels of MEK and ERK	Onco Targets Ther. 2020 Jun 18;13:5795-5805

AZD8330 动物实验

Species Caenorhabditis elegans	Animal Model ST65 (ncIs13) strain	Administration	Dosage	Frequency	Description	References
Caenorhabditis elegans	ST65 (ncIs13) strain	Liquid culture	50 μM	5 days	AZD8330 significantly inhibited vulva formation in C. elegans at 50 μmol/L, with only 3.8% of individuals forming a vulva. This experiment validated the inhibitory effect of AZD8330 as a MEK inhibitor on the MAPK/ERK signaling pathway in vivo.	Cancer Res Commun. 2024 Sep 1;4(9):2454-2462

AZD8330 参考文献

[1]Wallace EM, Lyssikatos JP, et al. Progress towards therapeutic small molecule MEK inhibitors for use in cancer therapy. Curr Top Med Chem. 2005;5(2):215-29.

[2]Yeh TC, Marsh V, et al. Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitor. Clin Cancer Res. 2007 Mar 1;13(5):1576-83.

AZD8330 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.17mL

0.43mL

0.22mL

10.84mL

2.17mL

1.08mL

21.68mL

4.34mL

2.17mL

AZD8330 技术信息

CAS号	869357-68-6
分子式	C₁₆H₁₇FIN₃O₄
分子量	461.23
SMILES Code	O=C(C(C=C1C)=C(NC2=CC=C(I)C=C2F)N(C)C1=O)NOCCO
MDL No.	MFCD18384989

别名	ARRY-424704; ARRY-704
运输	蓝冰
InChI Key	RWEVIPRMPFNTLO-UHFFFAOYSA-N
Pubchem ID	16666708

存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Keep in dark place, sealed in dry, store in freezer, under -20°C

溶解方案

细胞实验：

DMSO: 105 mg/mL(227.65 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验：请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用；以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

方案二

方案三

AZD8330 {[allProObj[0].p_purity_real_show]}

AZD8330 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

AZD8330 质控信息

AZD8330 生物活性

AZD8330 细胞实验

AZD8330 动物实验

AZD8330 参考文献

AZD8330 实验方案

AZD8330 技术信息

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AZD8330 {[allProObj[0].p_purity_real_show]}

AZD8330 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

AZD8330 质控信息

AZD8330 生物活性

AZD8330 细胞实验

AZD8330 动物实验

AZD8330 参考文献

AZD8330 实验方案

AZD8330 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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AZD8330 纯度/质量文件产品仅供科研