AZD8330

产品说明书

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Chemical Structure| 869357-68-6 同义名 : ARRY-424704; ARRY-704
CAS号 : 869357-68-6
货号 : A473635
分子式 : C16H17FIN3O4
纯度 : 99%+
分子量 : 461.23
MDL号 : MFCD18384989
存储条件：

Pure form Keep in dark place, sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(227.65 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • MEK1/2

    MEK1/2, IC50:7 nM
描述 AZD8330 is a selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.17mL

0.43mL

0.22mL

10.84mL

2.17mL

1.08mL

21.68mL

4.34mL

2.17mL
参考文献

[1]Wallace EM, Lyssikatos JP, et al. Progress towards therapeutic small molecule MEK inhibitors for use in cancer therapy. Curr Top Med Chem. 2005;5(2):215-29.

[2]Yeh TC, Marsh V, et al. Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitor. Clin Cancer Res. 2007 Mar 1;13(5):1576-83.