Gamma-Mangostin | γ-Mangostin | 5-HT Receptor Antagonist

Gamma-Mangostin/γ-倒捻子素 {[allProObj[0].p_purity_real_show]}

货号：A207435 同义名： γ-Mangostin

Gamma-Mangostin是一种从山竹果（Garcinia mangostana）果实中提取并纯化的天然产物，具有清除自由基、抗增殖和诱导HepG2细胞凋亡的作用。

Gamma-Mangostin/γ-倒捻子素化学结构
CAS号：31271-07-5

Gamma-Mangostin/γ-倒捻子素 3D分子结构
CAS号：31271-07-5

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Gamma-Mangostin/γ-倒捻子素质控信息

5-羟色胺受体亚型比较

产品名称	5-HT ↓ ↑	5-HT1 ↓ ↑	5-HT2 ↓ ↑	5-HT3 ↓ ↑	5-HT5 ↓ ↑	5-HT6 ↓ ↑	5-HT7 ↓ ↑	其他靶点	纯度
Desvenlafaxine	++ 5-HT, Ki: 40.2 nM								98%
Lamotrigine	+ 5-HT (human platelets), IC50: 240 μM 5-HT (rat brain synaptosomes), IC50: 474 μM								98%
Venlafaxine	✔								99%
Fluvoxamine maleate	✔								99%
Iloperidone	✔								99%
Ziprasidone HCl	✔								98+%
Atomoxetine HCI	+ 5-HT, Ki: 77 nM								98%
Dapoxetine HCl	✔								97%
Trazodone	✔								98+%
Clomipramine HCl	✔								98%
Mirtazapine	✔								99+%
Escitalopram oxalate	+++ 5-HT, Ki: 0.89 nM								97%
Duloxetine	✔								97%
Sertraline HCl	++ 5-HT, Ki: 13 nM								98%
Citalopram HBr	+++ serotonin reuptake, IC50: 1.8 nM								98%
Latrepirdine 2HCl	✔							GluR	99%
Fluoxetine HCl	✔								99.5%
Paroxetine HCl	✔							AChR	99%
BMY 7378		++ 5-HT1A, pIC50: 6.4 5-HT1D, pIC50: 5.9	+ 5-HT2, pIC50: 5.5						97%
Flibanserin		+++ 5-HT1A, Ki: 1 nM	+ 5-HT2A, Ki: 49 nM						95%
LY310762		+ 5-HT1D, Ki: 249 nM							99%+
Cyclobenzaprine HCI			✔						99%
Blonanserin			+++ 5-HT2, Ki: 3.98 nM						99%
Cyproheptadine HCl			++++ 5-HT2, IC50: 0.6 nM						99+%
Olanzapine			✔						99+%
Pimavanserin hemitartrate			+++ 5-HT2A, pIC50: 8.7						99%
Ketanserin			+++ 5-HT2C (Human), Ki: 2.5 nM 5-HT2C (Rat), Ki: 50 nM						99%+
Loxapine succinate			++ 5-HT2 (human), Ki: 6.8 nM 5-HT2 (bovine), Ki: 6.6 nM						98%
Agomelatine			✔						98%
Clozapine			✔						98%
Amitriptyline			+ 5-HT2, Ki: 235 nM					SERT	99%
PRX-08066 maleate			+++ 5-HT2B, IC50: 3.4 nM						98+%
RS-127445			++++ 5-HT2B, pIC50: 10.4 5-HT2B, pKi: 9.5						99%+
Sarpogrelate HCl			++++ 5-HT2C, Kd: 1.1 nM 5-HT2A, Kd: 2.1 nM						98%
Tropisetron				✔					99%
Ramosetron HCl				++++ 5-HT3 receptor, Ki: 0.091 nM					98%
Ondansetron				✔					99%
Granisetron				✔					98%
Alosetron HCl				✔					98%
Ondansetron HCl dihydrate				✔					98%
VUF10166				++++ 5-HT3AB, Ki: 22 nM 5-HT3A, Ki: 0.04 nM					99%+
Azasetron HCl				++++ 5-HT3, IC50: 0.33 nM					99%
Asenapine maleate		+++ 5-HT1B, pKi: 8.4 5-HT1A, pKi: 8.6	++++ 5-HT2A, pKi: 9.75 5-HT2C, pKi: 10.46		+++ 5-HT5A, pKi: 8.84	++++ 5-HT6, pKi: 9.6	++++ 5-HT7, pKi: 9.94		97%
Risperidone		++ 5-HT1D, Ki: 84.6 nM 5-HT1B, Ki: 14.9 nM	++++ 5-HT2C, Ki: 12 nM 5-HT2A, Ki: 61.9 nM		+ 5-HT5A, Ki: 206 nM		++ 5-HT7, Ki: 6.6 nM		98%
SB 271046 HCl						+++ 5-HT6, pKi: 8.92			99%+
Intepirdine						++++ 5-HT6, pKi: 9.63			99%+
SB-269970 HCl							++ 5-HT7, pKi: 8.3		98+%
BRL 15572		++ 5-HT1B, pKi: 6.1 5-HT1D, pKi: 6	++ 5-HT2A, pKi: 6.6 5-HT2B, pKi: 6.2			+ 5-HT6, pKi: 5.9	+ 5-HT7, pKi: 6.3		95%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Gamma-Mangostin/γ-倒捻子素生物活性

描述

gamma-Mangostin, a natural product isolated and purified from the fruits of Garcinia mangostana, has free radical scavenging activity, and antiproliferative and apoptotic activity in HepG2 cells.

Gamma-Mangostin/γ-倒捻子素细胞实验

Cell Line cell-free in vitro assays rat forebrain homogenate rat cortical cells rat cortical cells rat cortical cells rat cortical cells rat cortical cells rat cortical cells MDA-MB-231 cells HT22 hippocampal neuronal cells HT22 hippocampal neuronal cells Mouse brain membranes Mouse brain slices MDA-MB-231 cells Mouse brain slices	Concentration	Treated Time	Description	References
cell-free in vitro assays	0.3-10 μM	2 hours	To evaluate the inhibitory effect of Gamma-Mangostin on β-secretase activity, results showed significant inhibition of β-secretase activity.	Oxid Med Cell Longev. 2019 Mar 24;2019:3640753
rat forebrain homogenate	0.3-30 μM	1 hour	To evaluate the inhibitory effect of Gamma-Mangostin on lipid peroxidation, results showed significant inhibition of lipid peroxidation.	Oxid Med Cell Longev. 2019 Mar 24;2019:3640753
rat cortical cells	3-10 μM	2 hours	To evaluate the inhibitory effect of Gamma-Mangostin on H2O2-induced activation of caspases 3 and 9, results showed significant inhibition of caspase activation.	Oxid Med Cell Longev. 2019 Mar 24;2019:3640753
rat cortical cells	10 μM	2 hours	To evaluate the inhibitory effect of Gamma-Mangostin on H2O2-induced DNA fragmentation, results showed 10 μM Gamma-Mangostin significantly inhibited DNA fragmentation.	Oxid Med Cell Longev. 2019 Mar 24;2019:3640753
rat cortical cells	0.3-10 μM	2 hours	To evaluate the inhibitory effect of Gamma-Mangostin on H2O2-induced ROS generation, results showed 3-10 μM Gamma-Mangostin significantly inhibited ROS production.	Oxid Med Cell Longev. 2019 Mar 24;2019:3640753
rat cortical cells	0.3-10 μM	10 minutes	To evaluate the protective effect of Gamma-Mangostin against X/XO-induced oxidative neurotoxicity, results showed 10 μM Gamma-Mangostin completely reversed X/XO-induced cell death.	Oxid Med Cell Longev. 2019 Mar 24;2019:3640753
rat cortical cells	0.3-10 μM	5 minutes	To evaluate the protective effect of Gamma-Mangostin against H2O2-induced oxidative neurotoxicity, results showed 10 μM Gamma-Mangostin completely reversed H2O2-induced cell death.	Oxid Med Cell Longev. 2019 Mar 24;2019:3640753
rat cortical cells	0.3-10 μM	24 hours	To evaluate the effect of Gamma-Mangostin on neuronal cell viability, results showed no cytotoxicity at 0.3-10 μM.	Oxid Med Cell Longev. 2019 Mar 24;2019:3640753
MDA-MB-231 cells	10 µM	24 hours	Increased intracellular ROS levels	Oncotarget. 2019 Sep 24;10(54):5576-5591
HT22 hippocampal neuronal cells	2.5, 5, 10 μM	8 hours	To determine the effect of γ-mangostin on glutamate-induced intracellular reactive oxygen species (ROS) accumulation. Results showed that γ-mangostin significantly reduced glutamate-induced ROS accumulation.	Biomolecules. 2021 Jan 27;11(2):170
HT22 hippocampal neuronal cells	3.1, 6.2, 12.5 μM	24 hours	To investigate the protective effect of γ-mangostin against glutamate-induced apoptosis in HT22 cells. Results showed that γ-mangostin significantly inhibited glutamate-induced HT22 cell death, with effects similar to the positive control N-acetyl cysteine.	Biomolecules. 2021 Jan 27;11(2):170
Mouse brain membranes	3, 10, and 30 μM	60 minutes	Competitively inhibited [3H]-spiperone binding to 5-HT2A receptors	Biomolecules. 2025 May 7;15(5):681
Mouse brain slices	10-100 nM	15 minutes	Inhibited 5-HT-induced inositol phosphates accumulation	Biomolecules. 2025 May 7;15(5):681
MDA-MB-231 cells	10 µM	24 hours	Increased intracellular ROS levels	Iran J Pharm Res. 2023 Nov 10;22(1):e138856
Mouse brain slices	10-100 nM	15 minutes	Inhibited 5-HT-induced inositol phosphates accumulation	Br J Pharmacol. 1998 Mar;123(5):855-62

Cell Line

Concentration

Treated Time

Description

References

cell-free in vitro assays

0.3-10 μM

2 hours

To evaluate the inhibitory effect of Gamma-Mangostin on β-secretase activity, results showed significant inhibition of β-secretase activity.

Oxid Med Cell Longev. 2019 Mar 24;2019:3640753

rat forebrain homogenate

0.3-30 μM

1 hour

To evaluate the inhibitory effect of Gamma-Mangostin on lipid peroxidation, results showed significant inhibition of lipid peroxidation.

Oxid Med Cell Longev. 2019 Mar 24;2019:3640753

rat cortical cells

3-10 μM

2 hours

To evaluate the inhibitory effect of Gamma-Mangostin on H2O2-induced activation of caspases 3 and 9, results showed significant inhibition of caspase activation.

Oxid Med Cell Longev. 2019 Mar 24;2019:3640753

rat cortical cells

10 μM

2 hours

To evaluate the inhibitory effect of Gamma-Mangostin on H2O2-induced DNA fragmentation, results showed 10 μM Gamma-Mangostin significantly inhibited DNA fragmentation.

Oxid Med Cell Longev. 2019 Mar 24;2019:3640753

rat cortical cells

0.3-10 μM

2 hours

To evaluate the inhibitory effect of Gamma-Mangostin on H2O2-induced ROS generation, results showed 3-10 μM Gamma-Mangostin significantly inhibited ROS production.

Oxid Med Cell Longev. 2019 Mar 24;2019:3640753

rat cortical cells

0.3-10 μM

10 minutes

To evaluate the protective effect of Gamma-Mangostin against X/XO-induced oxidative neurotoxicity, results showed 10 μM Gamma-Mangostin completely reversed X/XO-induced cell death.

Oxid Med Cell Longev. 2019 Mar 24;2019:3640753

rat cortical cells

0.3-10 μM

5 minutes

To evaluate the protective effect of Gamma-Mangostin against H2O2-induced oxidative neurotoxicity, results showed 10 μM Gamma-Mangostin completely reversed H2O2-induced cell death.

Oxid Med Cell Longev. 2019 Mar 24;2019:3640753

rat cortical cells

0.3-10 μM

24 hours

To evaluate the effect of Gamma-Mangostin on neuronal cell viability, results showed no cytotoxicity at 0.3-10 μM.

Oxid Med Cell Longev. 2019 Mar 24;2019:3640753

MDA-MB-231 cells

10 µM

24 hours

Increased intracellular ROS levels

Oncotarget. 2019 Sep 24;10(54):5576-5591

HT22 hippocampal neuronal cells

2.5, 5, 10 μM

8 hours

To determine the effect of γ-mangostin on glutamate-induced intracellular reactive oxygen species (ROS) accumulation. Results showed that γ-mangostin significantly reduced glutamate-induced ROS accumulation.

Biomolecules. 2021 Jan 27;11(2):170

HT22 hippocampal neuronal cells

3.1, 6.2, 12.5 μM

24 hours

To investigate the protective effect of γ-mangostin against glutamate-induced apoptosis in HT22 cells. Results showed that γ-mangostin significantly inhibited glutamate-induced HT22 cell death, with effects similar to the positive control N-acetyl cysteine.

Biomolecules. 2021 Jan 27;11(2):170

Mouse brain membranes

3, 10, and 30 μM

60 minutes

Competitively inhibited [3H]-spiperone binding to 5-HT2A receptors

Biomolecules. 2025 May 7;15(5):681

Mouse brain slices

10-100 nM

15 minutes

Inhibited 5-HT-induced inositol phosphates accumulation

Biomolecules. 2025 May 7;15(5):681

MDA-MB-231 cells

10 µM

24 hours

Increased intracellular ROS levels

Iran J Pharm Res. 2023 Nov 10;22(1):e138856

Mouse brain slices

10-100 nM

15 minutes

Inhibited 5-HT-induced inositol phosphates accumulation

Br J Pharmacol. 1998 Mar;123(5):855-62

Gamma-Mangostin/γ-倒捻子素动物实验

Species ICR mice DdY mice DdY mice	Animal Model Scopolamine-induced memory impairment model 5-FMT-induced head-twitch response model 5-FMT-induced head-twitch response model	Administration	Dosage	Frequency	Description	References
ICR mice	Scopolamine-induced memory impairment model	Oral	10 and 30 mg/kg	Single administration	To evaluate the improving effect of Gamma-Mangostin on scopolamine-induced memory impairment, results showed 10 and 30 mg/kg doses significantly improved memory impairment.	Oxid Med Cell Longev. 2019 Mar 24;2019:3640753
DdY mice	5-FMT-induced head-twitch response model	Intracerebroventricular injection	10-40 nmol/mouse	Single injection, observed for 90 minutes	Inhibited 5-FMT-induced head-twitch response by blocking 5-HT2A receptors	Biomolecules. 2025 May 7;15(5):681
DdY mice	5-FMT-induced head-twitch response model	Intracerebroventricular injection	10-40 nmol/mouse	Single injection, observed for 90 minutes	Inhibited 5-FMT-induced head-twitch response by blocking 5-HT2A receptors	Br J Pharmacol. 1998 Mar;123(5):855-62

Species

ICR mice DdY mice DdY mice

Animal Model

Scopolamine-induced memory impairment model 5-FMT-induced head-twitch response model 5-FMT-induced head-twitch response model

Administration

Dosage

Frequency

Description

References

ICR mice

Scopolamine-induced memory impairment model

Oral

10 and 30 mg/kg

Single administration

To evaluate the improving effect of Gamma-Mangostin on scopolamine-induced memory impairment, results showed 10 and 30 mg/kg doses significantly improved memory impairment.

Oxid Med Cell Longev. 2019 Mar 24;2019:3640753

DdY mice

5-FMT-induced head-twitch response model

Intracerebroventricular injection

10-40 nmol/mouse

Single injection, observed for 90 minutes

Inhibited 5-FMT-induced head-twitch response by blocking 5-HT2A receptors

Biomolecules. 2025 May 7;15(5):681

DdY mice

5-FMT-induced head-twitch response model

Intracerebroventricular injection

10-40 nmol/mouse

Single injection, observed for 90 minutes

Inhibited 5-FMT-induced head-twitch response by blocking 5-HT2A receptors

Br J Pharmacol. 1998 Mar;123(5):855-62

Gamma-Mangostin/γ-倒捻子素参考文献

Gamma-Mangostin/γ-倒捻子素实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.52mL

0.50mL

0.25mL

12.61mL

2.52mL

1.26mL

25.23mL

5.05mL

2.52mL

Gamma-Mangostin/γ-倒捻子素技术信息

CAS号	31271-07-5
分子式	C₂₃H₂₄O₆
分子量	396.43
SMILES Code	O=C1C2=C(OC3=C1C(CC=C(C)C)=C(O)C(O)=C3)C=C(O)C(CC=C(C)C)=C2O
MDL No.	MFCD00951752

别名	γ-Mangostin
运输	蓝冰

存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Keep in dark place, sealed in dry, 2-8°C

溶解方案

细胞实验：

DMSO: 105 mg/mL(264.86 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验：请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用；以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

方案二

方案三

Gamma-Mangostin/γ-倒捻子素 {[allProObj[0].p_purity_real_show]}

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