Rhyncholphylline是从钩藤（Uncaria rhynchophylla）中分离和纯化的生物碱，具有保护作用，可防止缺血性损伤和谷氨酸诱导的神经元死亡，并抑制培养神经元中的 MA 损伤作用，是一种钙通道阻滞剂。
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Rhynchophylline (Rhy) is a plant-derived indole alkaloid isolated from Uncaria species[3]. Rhy effectively obstructs the expansive signaling pathways of degenerative diseases, including Alzheimer disease, Parkinson disease, epilepsy and amyotrophic lateral sclerosis, and stimulates neurogenesis. Rhy altered expression level of BM-MSC proliferation/differentiation-related transcription genes[4]. Rhy can protect the neuronal cultures against MA (methamphetamine) exposure and promptly attenuate intracellular calcium overload triggered by MA challenge[5]. Rhy, which is blood-brain barrier permeable, is beneficial to amyloid pathology and regulates multiple molecular pathways[6]. Rhynchophylline can alleviate asthma through suppressing autophagy in asthma, and that JAK2/STAT3 signal was involved in this effect of rhynchophylline[7]. Rhy ameliorated MI/R (myocardial ischemia‑reperfusion) injury through the modulation of mitochondrial mechanisms[8].
Rhyncholphylline/钩藤碱 细胞实验
Cell Line
Concentration
Treated Time
Description
References
Rat hippocampal neurons
500 nM
2 hours
To investigate the effect of Aβ on EphA4 tyrosine phosphorylation, results showed that Aβ increased EphA4 tyrosine phosphorylation
Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9959-64.
Human lung fibroblast (HFL1) cells
0, 50, 100, 200, 400 ng/mL
48 hours
To evaluate the effect of Rhynchophylline on TGF-β1-induced expression of fibrotic markers. Results showed that Rhynchophylline decreased the TGF-β1-induced abnormal overexpression of fibronectin (FN), collagen I (Col I), and α-smooth muscle actin (α-SMA) in a dose-dependent manner.
Transl Lung Cancer Res. 2023 Mar 31;12(3):427-445.
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