Rhyncholphylline

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Chemical Structure| 76-66-4 同义名 : Rhynchophylline; Mitrinermine
CAS号 : 76-66-4
货号 : A324112
分子式 : C22H28N2O4
纯度 : 98%
分子量 : 384.47
MDL号 : MFCD00221748
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(65.02 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Rhynchophylline (Rhy) is a plant-derived indole alkaloid isolated from Uncaria species[3]. Rhy effectively obstructs the expansive signaling pathways of degenerative diseases, including Alzheimer disease, Parkinson disease, epilepsy and amyotrophic lateral sclerosis, and stimulates neurogenesis. Rhy altered expression level of BM-MSC proliferation/differentiation-related transcription genes[4]. Rhy can protect the neuronal cultures against MA (methamphetamine) exposure and promptly attenuate intracellular calcium overload triggered by MA challenge[5]. Rhy, which is blood-brain barrier permeable, is beneficial to amyloid pathology and regulates multiple molecular pathways[6]. Rhynchophylline can alleviate asthma through suppressing autophagy in asthma, and that JAK2/STAT3 signal was involved in this effect of rhynchophylline[7]. Rhy ameliorated MI/R (myocardial ischemia‑reperfusion) injury through the modulation of mitochondrial mechanisms[8].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.60mL

0.52mL

0.26mL

13.00mL

2.60mL

1.30mL

26.01mL

5.20mL

2.60mL
参考文献

[1]He Y, Zeng SY, et al. Effects of rhynchophylline on GluN1 and GluN2B expressions in primary cultured hippocampal neurons. Fitoterapia. 2014 Oct;98:166-73.

[2]Li J, Liu W, Peng Q, et al. Effect of rhynchophylline on conditioned place preference on expression of NR2B in methamphetamine-dependent mice. Biochem Biophys Res Commun. 2014 Sep 26;452(3):695-700.

[3]Geetha RG, Ramachandran S. Recent Advances in the Anti-Inflammatory Activity of Plant-Derived Alkaloid Rhynchophylline in Neurological and Cardiovascular Diseases. Pharmaceutics. 2021 Jul 29;13(8):1170

[4]Kaneko Y, Coats AB, Tuazon JP, Jo M, Borlongan CV. Rhynchophylline promotes stem cell autonomous metabolic homeostasis. Cytotherapy. 2020 Feb;22(2):106-113

[5]Xu DD, Hoeven R, Rong R, Cho WC. Rhynchophylline Protects Cultured Rat Neurons against Methamphetamine Cytotoxicity. Evid Based Complement Alternat Med. 2012;2012:636091

[6]Fu WY, Hung KW, Lau SF, Butt B, Yuen VW, Fu G, Chan IC, Ip FCF, Fu AKY, Ip NY. Rhynchophylline Administration Ameliorates Amyloid-β Pathology and Inflammation in an Alzheimer's Disease Transgenic Mouse Model. ACS Chem Neurosci. 2021 Nov 17;12(22):4249-4256

[7]Li H, Bi Q, Cui H, Lv C, Wang M. Suppression of autophagy through JAK2/STAT3 contributes to the therapeutic action of rhynchophylline on asthma. BMC Complement Med Ther. 2021 Jan 7;21(1):21

[8]Qin QJ, Cui LQ, Li P, Wang YB, Zhang XZ, Guo ML. Rhynchophylline ameliorates myocardial ischemia/reperfusion injury through the modulation of mitochondrial mechanisms to mediate myocardial apoptosis. Mol Med Rep. 2019 Apr;19(4):2581-2590