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/ Linderalactone/乌药内酯

Linderalactone/乌药内酯 {[allProObj[0].p_purity_real_show]}

货号：A572163

Linderalactone是一种从 Lindera aggregata 中提取的倍半萜烯内酯，IC50 为 15 µM，可抑制肺癌细胞增殖并诱导凋亡。

Linderalactone/乌药内酯 化学结构 CAS号：728-61-0
Linderalactone/乌药内酯 化学结构
CAS号：728-61-0
Linderalactone/乌药内酯 3D分子结构
CAS号：728-61-0
Linderalactone/乌药内酯 化学结构 CAS号：728-61-0
Linderalactone/乌药内酯 3D分子结构 CAS号：728-61-0
规格 价格 会员价 库存 数量
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Linderalactone/乌药内酯 纯度/质量文件 产品仅供科研

货号：A572163 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 H1 receptor ↓ H2 receptor ↓ H3 receptor ↓ H4 receptor ↓ Histamine receptor ↓ 其他靶点 纯度
Hydroxyzine 2HCl 99+%
Cyclizine ✔ 97%
Loratadine +

B(0)AT2, IC50: 4 μM

 		98%
Desloratadine ++

Histamine H1 receptor, IC50: 51 nM

 		98%
Doxylamine succinate ✔ 99%
Ebastine ✔ 98%
Tripelennamine HCl +

H1 receptor, IC50: 30 μM

 		98%
Meclizine 2HCl ✔ 98%
Chlorpheniramine maleate +++

Histamine H1 receptor, IC50: 12 nM

 		99%
Diphenhydramine HCl ✔ 99%
Alcaftadine ++++

H1 receptor, pKi: 8.5

 		++

H2 receptor, pKi: 7.2

 		99%+
Fexofenadine HCl ++

Histamine H1 receptor, IC50: 246 nM

 		99%+
Bilastine +++

H1 receptor, Ki: 44.15 nM

 		98%
Pemirolast potassium ✔ 98%
Bepotastine besilate +

Histamine H1 receptor, pIC50: 5.7

 		98%
Mizolastine +++

Histamine H1 receptor, IC50: 47 nM

 		98%
Brompheniramine maleate ✔ 98%
Carbinoxamine maleate salt ✔ 99+%
Clemastine fumarate ++++

Histamine H1 receptor, IC50: 3 nM

 		98%
Ketotifen fumarate salt ✔ 95%
Rupatadine Fumarate ++

Histamine H1 receptor, Ki: 102 nM

 		PAFR 98%
Famotidine ✔ 97%
Roxatidine Acetate HCl +

Histamine H2 receptor, IC50: 3.2 μM

 		98%
Lafutidine ✔ 99%
Cimetidine ✔ 98%
Nizatidine ++++

Histamine H2 receptor, IC50: 0.9 nM

 		AChE 98%
Ranitidine ✔ 96%
Betahistine +

Histamine H3 receptor, IC50: 1.9 μM

 		99%
Ciproxifan maleate +++

Histamine H3 receptor, IC50: 9.2 nM

 		99%+
S 38093 ++

human H3 receptor, Ki: 1.2 μM

rat H3 receptor, Ki: 1.44 μM

 		98%
JNJ-7777120 ++++

Histamine H4 receptor, Ki: 4.5 nM

 		99%
Azelastine HCl ✔ 98%
Epinastine HCl ✔ 99%
Levodropropizine ✔ 97%
Cyproheptadine HCl ✔ 98%
Hesperetin ✔ 97%
Olopatadine HCl ✔ 98%
Mianserin HCl ✔ 99+%
Buclizine 2HCl ✔ 95%
Latrepirdine 2HCl ✔ GluR 99%
Cetirizine 2HCl ✔ 98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Linderalactone/乌药内酯 生物活性

描述 Linderalactone, a natural product isolated and purified from the roots of Lindera aggregata, shows significant inhibitory effects on superoxide anion generation by human neutrophils in response to fMLP/CB, values of IC50 is 8.48 µg/mL.

Linderalactone/乌药内酯 细胞实验

Cell Line
Concentration Treated Time Description References
SW-1990 0, 30, 40, 50, 60, 70, 80, 90, and 100 μM 0, 24, and 48h Linderalactone inhibited pancreatic cancer cell activity in a time- and dose-dependent manner. J Oncol. 2022 Aug 4;2022:8675096.
CFPAC-1 0, 30, 40, 50, 60, 70, 80, 90, and 100 μM 0, 24, and 48h Linderalactone inhibited pancreatic cancer cell activity in a time- and dose-dependent manner. J Oncol. 2022 Aug 4;2022:8675096.
BXPC-3 0, 30, 40, 50, 60, 70, 80, 90, and 100 μM 0, 24, and 48h Linderalactone inhibited pancreatic cancer cell activity in a time- and dose-dependent manner. J Oncol. 2022 Aug 4;2022:8675096.
ASPC-1 0, 30, 40, 50, 60, 70, 80, 90, and 100 μM 0, 24, and 48h Linderalactone inhibited pancreatic cancer cell activity in a time- and dose-dependent manner. J Oncol. 2022 Aug 4;2022:8675096.
LX-2 cells 10 μM 24 h To evaluate the effect of LIN on fibrogenic gene expression in LX-2 cells, results showed that LIN significantly reduced the expression of ACTA2, VIM, TGF-β, FN1, DES, and COL1A1. Front Pharmacol. 2023 Feb 9;14:1098463.

Linderalactone/乌药内酯 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
BALB/c nude mice Pancreatic cancer xenograft model Intraperitoneal injection 25mg/kg and 50mg/kg Every three days for three weeks Linderalactone inhibited tumor growth without obvious chemical toxicity. J Oncol. 2022 Aug 4;2022:8675096.
C57BL/6 mice DSS-induced colitis model Oral gavage 0.5, 1, 2 g/kg Once daily for 14 days Improved colitis symptoms, reduced intestinal permeability, modulated Th17/Treg cell balance Front Pharmacol. 2021 May 13;12:615506
C57BL/6 mice CCl4-induced liver fibrosis model Intragastric administration 20 and 40 mg/kg Once daily for 4 weeks To evaluate the therapeutic effect of LIN on CCl4-induced liver fibrosis, results showed that LIN significantly reduced serum AST/ALT levels, liver hydroxyproline content, and collagen deposition, ameliorating liver fibrosis. Front Pharmacol. 2023 Feb 9;14:1098463.

Linderalactone/乌药内酯 参考文献

[1]Chang WA, Lin ES, et al. Isolinderalactone inhibits proliferation of A549 human non‑small cell lung cancer cells by arresting the cell cycle at the G0/G1 phase and inducing a Fas receptor and soluble Fas ligand-mediated apoptotic pathway. Mol Med Rep. 2014 May;9(5):1653-9.

[2]Gan LS, Zheng YL, et al. Sesquiterpene lactones from the root tubers of Lindera aggregata. J Nat Prod. 2009 Aug;72(8):1497-501.

Linderalactone/乌药内酯 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.09mL

0.82mL

0.41mL

20.47mL

4.09mL

2.05mL

40.93mL

8.19mL

4.09mL

Linderalactone/乌药内酯 技术信息

CAS号728-61-0
分子式C15H16O3
分子量 244.29
SMILES Code O=C1C2=C[C@@](C3=C(OC=C3C)C/C(C)=C/CC2)([H])O1
MDL No. MFCD12031632
别名
运输蓝冰
InChI Key LWCKQMHMTSRRAA-QGQQYVBWSA-N
Pubchem ID 6450191
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Keep in dark place, sealed in dry, store in freezer, under -20°C
溶解方案

DMSO: 35 mg/mL(143.27 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一
方案 二

Tags: Linderalactone | 728-61-0 | Apoptosis Inducer | Apoptosis | Apoptosis | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Linderalactone/乌药内酯 纯度/质量文件 | Linderalactone/乌药内酯 亚型比较 | Linderalactone/乌药内酯 生物活性 | Linderalactone/乌药内酯 参考文献 | Linderalactone/乌药内酯 实验方案 | Linderalactone/乌药内酯 技术信息

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