There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Cimetidine is a histamine H2 receptor blocker with Ki and IC50 values of about 0.75 and 0.85 uM, respectively. It inhibits acid release from stomach and is used for gasterointestinal diseases and could inhibit converting hydrogen peroxide (H2O2) in a non-competitive manner. Cimetidine could non-competitively inhibit the liver catalase with high affinity. Binding of cimetidine to the enzyme induced conformational alteration in the enzyme[3]. Cimetidine, an H2-receptor antagonist, has been shown to enhance a variety of immunologic functions both in vivo and in vitro because of its inhibitory effects on suppressor-cell function. Patients receiving cimetidine have been shown to exhibit enhanced cell-mediated immunity as evaluated by increased response to skin-test antigens, restoration of sensitivity following development of acquired tolerance, and increased responses of lymphocytes to mitogen stimulation[4]. The clearance (Cl) of CsA (Cyclosporine) was significantly reduced following treatment with cimetidine when compared to the Cl value obtained in the control group (15.46 versus 10.36 ml/min/kg). Cimetidine is an inhibitor of the mixed function oxidase system enzyme system, it inhibits the metabolism of CsA[5].
Cimetidine/西咪替丁 细胞实验
Cell Line
Concentration
Treated Time
Description
References
HEK293 cells
25 µM
15 min
Evaluate the inhibitory effect of Bictegravir on MATE1-mediated dofetilide transport
Int J Mol Sci. 2022 Aug 3;23(15):8607.
LIM2412
1X10^-10M to 1X10^-6M
24 hours
To study the effect of histamine and cimetidine on the proliferation of LIM2412 cells. Histamine significantly stimulated the proliferation of LIM2412 cells, and cimetidine antagonized this effect.
Gut. 1994 Nov;35(11):1632-6.
C170
1X10^-10M to 1X10^-6M
24 hours
To study the effect of histamine and cimetidine on the proliferation of C170 cells. Histamine significantly stimulated the proliferation of C170 cells, and cimetidine antagonized this effect.
Gut. 1994 Nov;35(11):1632-6.
MKN45G
10^-5 M
3-4 days
Cimetidine reversed histamine-stimulated proliferation of MKN45G cells but had no effect on basal growth.
Gut. 1993 Aug;34(8):1091-6.
MKN45
10^-5 M
3-4 days
Cimetidine reversed histamine-stimulated proliferation of MKN45 cells but had no effect on basal growth.
Gut. 1993 Aug;34(8):1091-6.
Il-1β:GFP reporter cells in zebrafish larval spinal cord injury model
10µM
4 hours pre-incubation followed by 16-18 hours incubation
Cimetidine significantly reduced il-1β expression and decreased inflammatory response
Theranostics. 2023 Apr 23;13(8):2531-2551.
Normal rat kidney cell line (NRK)
0.1 mM
4 hours
To study the protective effect of cimetidine on cisplatin-induced cytotoxicity. Cimetidine, similar to Klotho, inhibits OCT-mediated cisplatin uptake, thereby reducing cytotoxicity.
Kidney Int. 2014 Apr;85(4):855-70.
SKOV-3 cells
1 mM
30 minutes
Evaluate the effect of cimetidine on cisplatin uptake in SKOV-3 cells, results showed cimetidine did not affect cisplatin uptake
Clin Cancer Res. 2010 Aug 15;16(16):4198-206.
293Flp-In cells
1 mM
30 minutes
Evaluate the inhibitory effect of cimetidine on OCT2-mediated TEA transport, results showed cimetidine significantly inhibited OCT2 function
Clin Cancer Res. 2010 Aug 15;16(16):4198-206.
A549 lung adenocarcinoma cells
500µM–3000µM
2 treatments
Evaluated apoptosis by TUNEL assay, showing significant increase in apoptosis after cimetidine treatment
Sci Transl Med. 2011 Aug 17;3(96):96ra77.
A549 lung adenocarcinoma cells
250µM, 500µM, 1,000µM, 1,500µM, 2,000µM
3 treatments
Assessed the inhibitory effect of cimetidine on lung cancer cell growth and proliferation, showing dose-dependent inhibition
Sci Transl Med. 2011 Aug 17;3(96):96ra77.
Cimetidine/西咪替丁 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
C57BL/6J mice
Wild-type and OCT1/2 knockout mice
Intravenous
30 mg/kg BW bolus followed by a maintenance infusion at a rate of 10 mg/kg/BW per h
Continuous infusion for ~45 min after bolus
Cimetidine significantly reduced the secretion fraction from 0.56 to 0.34 in male mice and from 0.44 to 0.23 in female mice, and significantly increased plasma creatinine levels.
Kidney Int. 2010 Mar;77(6):519-26
Balb/c nu/nu mice
Subcutaneous xenograft model
Oral
50-200 mg/kg/day
Daily administration, lasting 21-28 days
To study the effect of cimetidine on the growth of C170 and LIM2412 xenografts. Cimetidine significantly inhibited tumor growth, reducing the final tumor volume of C170 to 44% of controls and LIM2412 to 60% of controls.
Gut. 1994 Nov;35(11):1632-6.
Nude mice
MKN45G xenograft model
Drinking water
100 mg/kg/day
Daily administration until the end of the experiment
Cimetidine reversed histamine-stimulated growth of MKN45G xenografts and inhibited basal growth.
Gut. 1993 Aug;34(8):1091-6.
SCID mice
A549 lung adenocarcinoma xenograft model
Intraperitoneal injection
25 mg/kg/day, 50 mg/kg/day, 100 mg/kg/day
Once daily for 12 days
Assessed the inhibitory effect of cimetidine on tumor growth, showing dose-dependent inhibition with the highest dose approaching the efficacy of the positive control doxorubicin
Sci Transl Med. 2011 Aug 17;3(96):96ra77.
Mice
Mycoplasma pneumonia model
Intraperitoneal injection
40 mg/kg
Daily for 7 days
To evaluate the effect of cimetidine on the inflammatory response in mycoplasma pneumonia. Results showed that cimetidine significantly reduced lung inflammation and the ratio of lung weight to body weight.
J Exp Med. 2006 Dec 25;203(13):2907-17
Mice
Spinal cord contusion model
Intraperitoneal injection
15 mg/kg
Twice daily for 14 days
Cimetidine significantly improved locomotor recovery in mice, reduced tissue loss, and promoted a shift towards a pro-regenerative profile of cytokine gene expression
Theranostics. 2023 Apr 23;13(8):2531-2551.
Adult CD1 mice
Adult mice
Oral
5 mg
1-2 hours before inoculation
Pretreatment with cimetidine increased gastric pH from approximately 3.0 to 3.7, preventing most of the loss of rotavirus infectivity in the adult mouse gastrointestinal tract.
J Clin Invest. 1992 Jun;89(6):1741-5
Mice
Oct1/2(−/−) mice
Intravenous injection
30 mg/kg
Single dose
Evaluate the protective effect of cimetidine on cisplatin-induced nephrotoxicity, results showed cimetidine significantly reduced changes in urinary NAG activity
Clin Cancer Res. 2010 Aug 15;16(16):4198-206.
Mice
Yersinia enterocolitica infection model
Intraperitoneal injection
20 mg/kg body weight
Once daily until the conclusion of the experiment
To investigate the effect of H2 receptor antagonist cimetidine on Yersinia enterocolitica infection. Results showed that cimetidine-treated mice had decreased survival and increased bacterial colonization in PPs and MLNs.
Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9268-73
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