Isoliquiritigenin | GU17;ISL;GU 17, Isoliquiritigenin;4,2',4'-Trihydroxychalcone;ILQ;SJ000286237;Isoliquiritigen | Plant Standard | Sirtuin | Aldose Reductase

Isoliquiritigenin/异甘草素 {[allProObj[0].p_purity_real_show]}

货号：A289179 同义名： GU17; ISL

Isoliquiritigenin是一种从甘草根中提取的抗肿瘤黄酮类化合物，以 320 nM 的 IC50 抑制醛糖还原酶，并以 24.7 μM 的 EC50 抑制流感病毒复制。

Isoliquiritigenin/异甘草素化学结构
CAS号：961-29-5

Isoliquiritigenin/异甘草素 3D分子结构
CAS号：961-29-5

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Sirtuin 亚型比较

产品名称	SIRT1 ↓ ↑	SIRT2 ↓ ↑	SIRT3 ↓ ↑	SIRT5 ↓ ↑	SIRT6 ↓ ↑	SIRT7 ↓ ↑	Sirtuin ↓ ↑	其他靶点	纯度
Selisistat	++++ SIRT1, IC50: 38 nM								99%+
Resveratrol	✔								98%
Inauhzin	✔							p53	99%+
Suramin sodium salt	+++ SirT1, IC50: 297 nM			++ SirT5, IC50: 22 μM					99%+
Salermide	✔								99%
Quercetin Dihydrate	✔								95%
Sirtinol	+ SIRT1, IC50: 131 μM	++ SIRT2, IC50: 38 μM							98%+
AGK2		+++ SIRT2, IC50: 3.5 μM							99%+
Tenovin-3		✔						p53	99%+
3-TYP	++++ SIRT1, IC50: 88 nM	++++ SIRT2, IC50: 92 nM	++++ SIRT3, IC50: 16 nM						95%
Tenovin-6	++ SIRT1, IC50: 21 μM	++ SIRT2, IC50: 10 μM	+ SIRT3, IC50: 67 μM					p53	99%+
SirReal2		+++ SIRT2, IC50: 140 nM							99%+
Thiomyristoyl		++++ SIRT2, IC50: 28 nM							99%+
Et-29				✔					98%
OSS_128167	+ SIRT1, IC50: 1578 μM	+ SIRT2, IC50: 751 μM			+ SIRT6, IC50: 89 μM				98%
SIRT7 inhibitor 97491						+++ SIRT7, IC50: 325 nM			97%
Nicotinamide							✔		99+%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Isoliquiritigenin/异甘草素生物活性

描述

Isoliquiritigenin (ISL), a simple chalcone-type flavonoid, is derived from licorice compounds and is mainly present in foods, beverages, and tobacco^[3]. Isoliquiritigenin inhibited rat lens aldose reductase with an IC50 of 3.2 x 10(-7) M, using DL-glyceraldehyde as a substrate. It inhibited sorbitol accumulation in human red blood cells, with an IC50 of 2.0 x 10(-6) M^[4]. Isoliquiritigenin treatment markedly ameliorated cardiomyocytes contractile dysfunction caused by hypoxia. Moreover, Isoliquiritigenin reduced the mitochondrial potential (Δψ) of isolated mouse cardiomyocytes^[3]. Isoliquiritigenin also showed the most potent inhibition of mouse rectal contraction induced by CCh(carbamylcholine) with an IC50 value of 1.70+/-0.07 microM^[5].

Isoliquiritigenin/异甘草素细胞实验

Cell Line NOZ cells SGC-996 cells HiBECs cells L-2F7 cells U87 cells SHG44 cells Mouse primary bone marrow-derived macrophages (BMMs)	Concentration	Treated Time	Description	References
NOZ cells	0–100 mM	24 hours, 48 hours, 72 hours	ISL significantly inhibited the proliferation of NOZ cells, with IC50 values of 151.3 mmol/L at 24 h, 59.5 mmol/L at 48 h, and 54.2 mmol/L at 72 h.	Chin Med J (Engl). 2023 Sep 20;136(18):2210-2220.
SGC-996 cells	0–100 mM	24 hours, 48 hours, 72 hours	ISL significantly inhibited the proliferation of SGC-996 cells, with IC50 values of 210.1 mmol/L at 24 h, 72.9 mmol/L at 48 h, and 51.9 mmol/L at 72 h.	Chin Med J (Engl). 2023 Sep 20;136(18):2210-2220.
HiBECs cells	50 mM, 70 mM	48 hours	ISL at 50 mmol/L and 70 mmol/L did not significantly alter the growth of HiBECs cells.	Chin Med J (Engl). 2023 Sep 20;136(18):2210-2220.
L-2F7 cells	50 mM, 70 mM	48 hours	ISL at 50 mmol/L and 70 mmol/L did not significantly alter the growth of L-2F7 cells.	Chin Med J (Engl). 2023 Sep 20;136(18):2210-2220.
U87 cells	5 µM	48 hours	To investigate the effects of ISL on circRNA expression, it was found that ISL significantly downregulated circ0030018 expression	MedComm (2020). 2023 May 26;4(3):e282.
SHG44 cells	5 µM	48 hours	To investigate the effects of ISL on circ0030018 expression, it was found that ISL significantly downregulated circ0030018 expression	MedComm (2020). 2023 May 26;4(3):e282.
Mouse primary bone marrow-derived macrophages (BMMs)	16 or 64 μg/mL	5 days	MSNs-ISL significantly inhibited RANKL-induced osteoclast generation, decreased the size and quantity of sealing zones, and reduced the osteolytic capacity of osteoclasts in vitro.	Theranostics. 2019 Jul 9;9(18):5183-5199.

Cell Line

NOZ cells SGC-996 cells HiBECs cells L-2F7 cells U87 cells SHG44 cells Mouse primary bone marrow-derived macrophages (BMMs)

Concentration

Treated Time

Description

References

NOZ cells

0–100 mM

24 hours, 48 hours, 72 hours

ISL significantly inhibited the proliferation of NOZ cells, with IC50 values of 151.3 mmol/L at 24 h, 59.5 mmol/L at 48 h, and 54.2 mmol/L at 72 h.

Chin Med J (Engl). 2023 Sep 20;136(18):2210-2220.

SGC-996 cells

0–100 mM

24 hours, 48 hours, 72 hours

ISL significantly inhibited the proliferation of SGC-996 cells, with IC50 values of 210.1 mmol/L at 24 h, 72.9 mmol/L at 48 h, and 51.9 mmol/L at 72 h.

Chin Med J (Engl). 2023 Sep 20;136(18):2210-2220.

HiBECs cells

50 mM, 70 mM

48 hours

ISL at 50 mmol/L and 70 mmol/L did not significantly alter the growth of HiBECs cells.

Chin Med J (Engl). 2023 Sep 20;136(18):2210-2220.

L-2F7 cells

50 mM, 70 mM

48 hours

ISL at 50 mmol/L and 70 mmol/L did not significantly alter the growth of L-2F7 cells.

Chin Med J (Engl). 2023 Sep 20;136(18):2210-2220.

U87 cells

5 µM

48 hours

To investigate the effects of ISL on circRNA expression, it was found that ISL significantly downregulated circ0030018 expression

MedComm (2020). 2023 May 26;4(3):e282.

SHG44 cells

5 µM

48 hours

To investigate the effects of ISL on circ0030018 expression, it was found that ISL significantly downregulated circ0030018 expression

MedComm (2020). 2023 May 26;4(3):e282.

Mouse primary bone marrow-derived macrophages (BMMs)

16 or 64 μg/mL

5 days

MSNs-ISL significantly inhibited RANKL-induced osteoclast generation, decreased the size and quantity of sealing zones, and reduced the osteolytic capacity of osteoclasts in vitro.

Theranostics. 2019 Jul 9;9(18):5183-5199.

Isoliquiritigenin/异甘草素动物实验

Species C57/BL6 mice BALB/c Nude mice	Animal Model LPS-mediated calvarial bone erosion model NOZ cell xenograft model	Administration	Dosage	Frequency	Description	References
C57/BL6 mice	LPS-mediated calvarial bone erosion model	Subcutaneous injection	50 mg/kg	Once every 2 days for 7 days	MSNs-ISL could block osteoclast activity, relieve inflammation-related calvarial bone destruction in vivo, and suppress c-Fos, NFATc1, and cathepsin K expression levels.	Theranostics. 2019 Jul 9;9(18):5183-5199.
BALB/c Nude mice	NOZ cell xenograft model	Gavage	50 mg/kg	Every 2 days for 28 days	ISL significantly inhibited tumor growth in the NOZ cell xenograft model, reducing tumor volume to less than 10% of the control group. HMOX1-deficient or GPX4-overexpressing NOZ cells partially reversed the inhibitory effect of ISL.	Chin Med J (Engl). 2023 Sep 20;136(18):2210-2220.

Species

C57/BL6 mice BALB/c Nude mice

Animal Model

LPS-mediated calvarial bone erosion model NOZ cell xenograft model

Administration

Dosage

Frequency

Description

References

C57/BL6 mice

LPS-mediated calvarial bone erosion model

Subcutaneous injection

50 mg/kg

Once every 2 days for 7 days

MSNs-ISL could block osteoclast activity, relieve inflammation-related calvarial bone destruction in vivo, and suppress c-Fos, NFATc1, and cathepsin K expression levels.

Theranostics. 2019 Jul 9;9(18):5183-5199.

BALB/c Nude mice

NOZ cell xenograft model

Gavage

50 mg/kg

Every 2 days for 28 days

ISL significantly inhibited tumor growth in the NOZ cell xenograft model, reducing tumor volume to less than 10% of the control group. HMOX1-deficient or GPX4-overexpressing NOZ cells partially reversed the inhibitory effect of ISL.

Chin Med J (Engl). 2023 Sep 20;136(18):2210-2220.

Isoliquiritigenin/异甘草素参考文献

Isoliquiritigenin/异甘草素实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.90mL

0.78mL

0.39mL

19.51mL

3.90mL

1.95mL

39.02mL

7.80mL

3.90mL

Isoliquiritigenin/异甘草素技术信息

CAS号	961-29-5
分子式	C₁₅H₁₂O₄
分子量	256.25
SMILES Code	O=C(C1=CC=C(O)C=C1O)/C=C/C2=CC=C(O)C=C2
MDL No.	MFCD00075907

别名	GU17; ISL; GU 17, Isoliquiritigenin; 4,2',4'-Trihydroxychalcone; ILQ; SJ000286237; Isoliquiritigen
运输	蓝冰
InChI Key	DXDRHHKMWQZJHT-FPYGCLRLSA-N
Pubchem ID	638278

存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Keep in dark place, inert atmosphere, 2-8°C

溶解方案

细胞实验：

DMSO: 105 mg/mL(409.75 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

无水乙醇: 100 mg/mL(390.24 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇

动物实验：请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用；以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

方案二

方案三

方案四

方案五

方案六

细胞研究

细胞系	浓度	检测类型	检测时间	活性说明	数据源

CHO cells		Cytotoxicity assay		Cytotoxicity against CHO cells by MTT assay, IC50=45.9 μM	19572738
colon 26-L5 cells		Cytotoxicity assay	72 h	Cytotoxicity against mouse colon 26-L5 cells after 72 hrs by MTT assay, IC50=21.8 μM	18440233
dog MDCK cells	20 ug/mL	Function assay	1 h	Antiviral activity against Influenza virus A/Puerto Rico/8/34 H1N1 infected in dog MDCK cells assessed as inhibition of viral replication at 20 ug/mL incubated at 1 hr post-infection measured after 24 hrs by hemagglutininating unit assay relative to control	22743086
dog MDCK cells		Function assay	8 h	Inhibition of PKC/p38MAPK-mediated nuclear-cytoplasmic viral ribonucleoprotein export in dog MDCK cells infected with Influenza virus A/Puerto Rico/8/34 H1N1 measured at 8 hrs post-infection by inmmunofluorescence	22743086
dog MDCK cells		Function assay		Restoration of GSH level in dog MDCK cells infected with Influenza virus A/Puerto Rico/8/34 H1N1 measured at 24 hrs post-infection by DTNB-based colometric assay	22743086
Hepa lclc7 cells		Cytotoxicity assay		Cytotoxicity against mouse Hepa lclc7 cells, IC50=39 μM	18076142
Hepa lclc7 cells		Function assay		Induction of mouse quinone reductase in mouse Hepa lclc7 cells assessed as concentration required to double enzyme activity	18076142
Hepa-1c1c7 cells		Function assay		Induction of quinone reductase activity in mouse Hepa-1c1c7 cells assessed as drug level required to double enzyme activity	12762787
human T47D cells		Function assay	96 h	Estrogenic activity in human T47D cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol after 96 hrs by alamar blue assay	19928832
HUVEC		Cytotoxicity assay	48 h	Toxicity against HUVEC incubated for 48 hrs by MTT assay, IC50=41.17 μM	25590864
J774.1 cells		Function assay	24 h	Inhibition of LPS-induced NO production in mouse J774.1 cells after 24 hrs by Griess reagent assay, IC50=29.3 μM	15974608
K562 cells		Cytotoxicity assay	48 h	Antitumor activity against human K562 cells incubated for 48 hrs by MTT assay, IC50=29.27 μM	25590864
KB cells		Growth inhibition assay		Compound concentration required to reduce the exponential growth of KB cells by 50%, CC50=12 μM	9767632
MCF7 cells	25-150 μM	Cytotoxicity assay	72 h	Cytotoxicity against human MCF7 cells at 25 to 150 uM after 72 hrs by MTT assay	18603336
MCF7 cells		Function assay	96 h	Estrogenic activity in human MCF7 cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol after 96 hrs by alamar blue assay	19928832
MCF7 cells		Function assay		Estrogenic activity in luciferase transfected human MCF7 cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol by luciferase reporter gene assay	19928832
mouse NIH3T3 cells		Function assay	8 h	Inhibition of cobalt chloride-induced HIF-1 activation expressed in mouse NIH3T3 cells after 8 hrs by luciferase reporter gene assay, IC50=4.8 μM	21112783
MT-4 cells		Growth inhibition assay		Compound concentration required to reduce the exponential growth of MT-4 cells by 50%, CC50=7.4 μM	9767632
NCI-H292 cells		Function assay		Inhibition of PKC-mediated PKD phosphorylation in human NCI-H292 cells infected with Influenza virus A/Puerto Rico/8/34 H1N1 measured at 6 hrs post-infection by immunoblotting analysis	22743086
NCI-H292 cells		Function assay		Inhibition of PKC-mediated p38MAPK phosphorylation in human NCI-H292 cells infected with Influenza virus A/Puerto Rico/8/34 H1N1 measured at 6 hrs post-infection by immunoblotting analysis	22743086
NCI-H292 cells		Function assay		Inhibition of PKC-mediated JNK phosphorylation in human NCI-H292 cells infected with Influenza virus A/Puerto Rico/8/34 H1N1 measured at 6 hrs post-infection by immunoblotting analysis	22743086
OE21 cells		Cytotoxicity assay	72 h	Cytotoxicity against human OE21 cells after 72 hrs by MTT assay, IC50=48 μM	21696954
PC3 cells		Cytotoxicity assay		Cytotoxicity against human PC3 cells, IC50=46.4 μM	16441066
RBL-1 cells		Function assay		In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined, IC50=35 μM	8254620
U937 cells	5 ug/ml	Function assay	24 h	Antiinflammatory activity in human U937 cells assessed as inhibition of LPS-induced CCL5 secretion at 5 ug/ml after 24 hrs by ELISA relative to control	21866899
U937 cells	5 ug/ml	Function assay		Inhibition of LPS-induced AP-1 activation in human U937 cells at 5 ug/ml after 1 hr relative to control	21866899

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