3-bromo-5-phenyl Salicylic Acid is a cell-permeable salicylic acid compound that acts as a highly potent, active-site directed and substrate competitive AKR1C1 inhibitor (Ki = 4 nM) with moderate to excellent selectivity over AKR1C2, AKR1C3 and AKR1C4 (Ki = 0.087, 4.2 and 18.2 µM, respectively).

Alrestatin is an inhibitor of aldose reductase, an enzyme involved in the pathogenesis of complications of diabetes mellitus, including diabetic neuropathy.

Aldose reductase-IN-1 is an inhibitor of aldose reductase with IC50 of 28.9 pM.

Nodakenetin is a natural product isolated and purified from the herbs of Peucedanum decursivum Maxim. with clinical efficacy.

AT-007 is a central nervous system (CNS) penetrant Aldose Reductase inhibitor (ARI) in Phase 1/2 development for treatment of Galactosemia.

Calceolarioside B 是从五叶地锦叶中分离得到的天然产物。它以 23.99 μM 的 IC50 显著抑制大鼠晶状体醛糖还原酶 (RLAR)。Calceolarioside B 以 94.60 μM 的 IC50 有效抑制 DPPH 自由基清除活性。

Poliumoside is a natural compound which exhibit significant inhibition of advanced glycation end product formation with IC50 values of 4.6-25.7 μM

ALR2-IN-1是一种高效、选择性的醛糖还原酶 (ALR2) 抑制剂，IC₅₀ 为 1.42 μM，具有抗氧化和抗糖化特性，适用于糖尿病并发症的研究。

Ganoderic acid C2是灵芝中的一种三萜，具有抗肿瘤活性，以及抗组胺、抗衰老和细胞毒性作用，并对大鼠晶状体醛糖还原酶 (RLAR) 具有显著抑制活性，IC50 值为 3.8 μM。

Imirestat (AL 1576) 是一种醛糖还原酶抑制剂，用于糖尿病研究。

Statil is a selective and noncompetitive aldose reductase 2 inhibitor with Ki value of 7.7nM.

Epalrestat is an aldose reductase inhibitor with IC50 of 72 nM, and used for the treatment of diabetic neuropathy.

Fidarestat is an inhibitor of aldose reductase, with IC50s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively; Fidarestat has the potential to treat diabetic disease.

Isoliquiritigenin是一种从甘草根中提取的抗肿瘤黄酮类化合物，以 320 nM 的 IC50 抑制醛糖还原酶，并以 24.7 μM 的 EC50 抑制流感病毒复制。

Byakangelicin, a main furanocoumarin constituent isolated and characterized as an aldose reductase inhibitor from the roots of Angelica dahurica, is an aldose reductase inhibitor and induces cytochrome P450 3A4 expression via transactivation of pregnane X receptors in human hepatocytes.

Ganoderic acid C6是一种具有抑制醛糖还原酶活性的化合物，适用于糖尿病及并发症的研究，尤其在抗氧化应激相关疾病中具有潜在的应用。

Soyasaponin Ba是从大豆中提取的天然产物，能够抑制醛糖还原酶 (ARI)，在糖尿病并发症的研究中显示出潜在的预防作用。

Soyasaponin Bb, a triterpenoid saponin that has been found in soy, selectively inhibits human recombinant renin (IC50 = 30 μg/ml). It can also inhibit the mouse brain sialyltransferase ST3GAL1 (Ki = 2.1 μM).

6-Methoxytricin是从艾蒿 (Artemisia iwayomogi) 中分离的一种类黄酮，能够抑制醛糖还原酶 (AR) 和晚期糖基化终产物 (AGE)，其 IC50 值分别为 30.29 μM 和 134.88 μM，具有潜在的抗糖尿病并发症作用。

Myrciacetin是一种黄酮类化合物，能够抑制大鼠晶状体醛糖还原酶，IC₅₀ 为 13 μM，适用于糖尿病并发症及其他代谢性疾病的研究。