There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Thiomyristoyl is an effective and specific inhibitor of SIRT2, exhibiting broad anti-cancer activity with minimal effects on non-cancerous cells. The inhibition of SIRT2 by Thiomyristoyl promotes ubiquitination and degradation of c-Myc, indicating potential therapeutic value against certain c-Myc-driven cancers. Thiomyristoyl inhibits SIRT2 with an IC50 of 28 nM, while it inhibits SIRT1 with an IC50 of 98 μM, and does not inhibit SIRT3 even at 200 μM. Thiomyristoyl has been shown to inhibit three human breast cancer cell lines: MCF-7, MDA-MB-468, and MDA-MB-231[1].
Thiomyristoyl/硫肉豆蔻酰 细胞实验
Cell Line
Concentration
Treated Time
Description
References
MDA-MB-231
25 µM
72 h
To evaluate the effect of TM on the viability of MDA-MB-231 cells, the results showed that TM significantly inhibited the viability of MDA-MB-231 cells.
Cancer Cell. 2016 Mar 14;29(3):297-310.
MDA-MB-468
25 µM
72 h
To evaluate the effect of TM on the viability of MDA-MB-468 cells, the results showed that TM significantly inhibited the viability of MDA-MB-468 cells.
Cancer Cell. 2016 Mar 14;29(3):297-310.
MCF-7
25 µM
72 h
To evaluate the effect of TM on the viability of MCF-7 cells, the results showed that TM significantly inhibited the viability of MCF-7 cells.
Cancer Cell. 2016 Mar 14;29(3):297-310.
HEK293T cells
0, 5, 10, 50, 100, 200 μM
To test the effect of different concentrations of BHJH-TM3 on TNF α fatty acylation levels. Results showed that the fluorescent labelling of TNF α increased significantly with increasing concentrations of BHJH-TM3, indicating effective inhibition of Sirt6 in cells.
Org Biomol Chem. 2014 Oct 14;12(38):7498-502.
HEK293T cells
200 μM
To test the inhibitory effect of Thiomyristoyl peptides on Sirt6 and the impact on TNF α fatty acylation levels. Results showed that Thiomyristoyl peptides significantly increased the fatty acylation level of TNF α, indicating effective inhibition of Sirt6 in cells.
Org Biomol Chem. 2014 Oct 14;12(38):7498-502.
Thiomyristoyl/硫肉豆蔻酰 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Mice
MDA-MB-231 xenograft model
Intraperitoneal injection
1.5 mg
Daily for 30 days
To evaluate the anti-tumor effect of TM in the MDA-MB-231 xenograft model, the results showed that TM significantly inhibited tumor growth.
Cancer Cell. 2016 Mar 14;29(3):297-310.
Thiomyristoyl/硫肉豆蔻酰 动物研究
Animal study
In a mouse model of breast cancer, Thiomyristoyl significantly suppresses tumor growth without apparent toxicity to the mice, as no significant weight loss was observed in mice treated with TM. Compared to control-treated mice, Thiomyristoyl-treated mice showed a moderate but statistically significant increase in acetylated-α-tubulin levels in tumors, confirming the in vivo inhibition of SIRT2 by Thiomyristoyl[1].
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