3-TYP further aggravated LPS-induced PDHA1 hyperacetylation and PDH inactivation, and promoted lactate production.
Cell Death Dis. 2023 Jul 21;14(7):457.
Primary mouse hippocampal neurons
50 μM
1 h
3-TYP, as a SIRT3 inhibitor, was used to study its effect on the protective role of HKL in the hippocampal neuronal AD model. The results showed that 3-TYP treatment reversed the protective effect of HKL on the hippocampal neuronal AD model and inhibited the activation of mitochondrial autophagy.
CNS Neurosci Ther. 2024 Aug;30(8):e14878.
H9c2 cells
50 μM
12 h
3-TYP was used to inhibit SIRT3 activity to verify the role of SIRT3 in the regulation of mitochondrial homeostasis by omentin1. The results showed that 3-TYP treatment significantly reduced the expression of SIRT3 and inhibited the improvement effects of omentin1 on mitochondrial function, mitochondrial fusion-fission dynamics, and mitophagy.
J Transl Med. 2022 Oct 4;20(1):447.
3T3-L1 preadipocytes
50 µM and 100 µM
3-TYP inhibited adipogenesis in 3T3-L1 preadipocytes, reducing adipogenesis compared to the control.
Int J Mol Sci. 2022 Mar 29;23(7):3740.
BMDMs
50 µM
1 h
To investigate the inhibitory effect of 3-TYP on SIRT3 and its impact on XBP1s expression. The results showed that 3-TYP significantly increased the production of XBP1s.
Front Immunol. 2023 May 19;14:1128543.
THP-1 cells
10 to 200 μM
Suppressed IFNβ and CXCL10 expression after VSV infection
Proc Natl Acad Sci U S A. 2024 Apr 23;121(17):e2314201121.
A549 cells
10 to 200 μM
Suppressed IFNβ, CXCL10, and ISG15 expression after VSV infection
Proc Natl Acad Sci U S A. 2024 Apr 23;121(17):e2314201121.
H1299 cells
10 to 200 μM
Suppressed IFNβ and CXCL10 expression after poly(I:C) LMW transfection
Proc Natl Acad Sci U S A. 2024 Apr 23;121(17):e2314201121.
3-TYP 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
C57BL/6 mice
Cecal ligation and puncture (CLP) model
Intraperitoneal injection
5 mg/kg
Single dose, 0.5 h before CLP
Pretreatment with 3-TYP significantly increased CLP-induced PDHA1 hyperacetylation and PDH inactivation, and exacerbated the elevation of renal lactate levels.
Cell Death Dis. 2023 Jul 21;14(7):457.
Mice
APP/PS1 mouse AD model
Intraperitoneal injection
50 mg/kg
Once daily for 5 days
3-TYP, as a SIRT3 inhibitor, was used to study its effect on the protective role of HKL in the AD mouse model. The results showed that 3-TYP treatment reversed the protective effect of HKL on the AD mouse model and inhibited the activation of hippocampal mitochondrial autophagy.
CNS Neurosci Ther. 2024 Aug;30(8):e14878.
C57BL/6N mice
Sepsis model
Intraperitoneal injection
5 mg/kg
Once daily for 3 days
To investigate the effect of 3-TYP on sepsis-associated acute lung injury, the results showed that 3-TYP reversed the protective effect of MK-4 on sepsis by inhibiting Sirt3 activity
J Inflamm Res. 2024 Oct 24;17:7675-7685
C57BL/6 mice
IMQ-induced psoriasis-like mouse model
Intraperitoneal injection
50 mg/kg
Every 2 days for 7 days
To investigate the effect of 3-TYP on IMQ-induced psoriasis-like skin inflammation. The results showed that the 3-TYP group displayed accelerated psoriasis-like skin lesions.
Front Immunol. 2023 May 19;14:1128543.
BALB/c mice
786-O cell subcutaneous xenograft model
Intraperitoneal injection
25 mg/kg
Every other day for 12 days
To verify the effect of MLT on RCC cell growth in vivo, the results showed that MLT significantly inhibited tumor growth in mice without affecting.
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