Hyperforin | TRPC6 Activator | AmBeed-信号通路专用抑制剂

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Hyperforin/贯叶金丝桃素 {[allProObj[0].p_purity_real_show]}

货号：A688823

Hyperforin, a pharmacologically active component of the medicinal plant Hypericum perforatum (St. John's wort), has been shown to be neuroprotective against acute ischemic stroke.

Hyperforin/贯叶金丝桃素化学结构
CAS号：11079-53-1

Hyperforin/贯叶金丝桃素 3D分子结构
CAS号：11079-53-1

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Hyperforin/贯叶金丝桃素纯度/质量文件产品仅供科研

货号：A688823 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]; • Cell, 2025. Ambeed. [ A122167 ]; • Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]; • Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]; • Nat. Nanotechnol., 2025. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]; 更多 >

5-羟色胺受体亚型比较

产品名称	5-HT ↓ ↑	5-HT1 ↓ ↑	5-HT2 ↓ ↑	5-HT3 ↓ ↑	5-HT5 ↓ ↑	5-HT6 ↓ ↑	5-HT7 ↓ ↑	其他靶点	纯度
Desvenlafaxine	++ 5-HT, Ki: 40.2 nM								98%
Lamotrigine	+ 5-HT (rat brain synaptosomes), IC50: 474 μM 5-HT (human platelets), IC50: 240 μM								98%
Venlafaxine	✔								99%
Fluvoxamine maleate	✔								99%
Iloperidone	✔								99%
Ziprasidone HCl	✔								98+%
Atomoxetine HCI	+ 5-HT, Ki: 77 nM								98%
Dapoxetine HCl	✔								97%
Trazodone	✔								98+%
Clomipramine HCl	✔								98%
Mirtazapine	✔								99+%
Escitalopram oxalate	+++ 5-HT, Ki: 0.89 nM								97%
Duloxetine	✔								97%
Sertraline HCl	++ 5-HT, Ki: 13 nM								98%
Citalopram HBr	+++ serotonin reuptake, IC50: 1.8 nM								98%
Latrepirdine 2HCl	✔							GluR	99%
Fluoxetine HCl	✔								99.5%
Paroxetine HCl	✔							AChR	99%
BMY 7378		++ 5-HT1A, pIC50: 6.4 5-HT1D, pIC50: 5.9	+ 5-HT2, pIC50: 5.5						97%
Flibanserin		+++ 5-HT1A, Ki: 1 nM	+ 5-HT2A, Ki: 49 nM						95%
LY310762		+ 5-HT1D, Ki: 249 nM							99%+
Cyclobenzaprine HCI			✔						99%
Blonanserin			+++ 5-HT2, Ki: 3.98 nM						99%
Cyproheptadine HCl			++++ 5-HT2, IC50: 0.6 nM						99+%
Olanzapine			✔						99+%
Pimavanserin hemitartrate			+++ 5-HT2A, pIC50: 8.7						99%
Ketanserin			+++ 5-HT2C (Human), Ki: 2.5 nM 5-HT2C (Rat), Ki: 50 nM						99%+
Loxapine succinate			++ 5-HT2 (human), Ki: 6.8 nM 5-HT2 (bovine), Ki: 6.6 nM						98%
Agomelatine			✔						98%
Clozapine			✔						98%
Amitriptyline			+ 5-HT2, Ki: 235 nM					SERT	99%
PRX-08066 maleate			+++ 5-HT2B, IC50: 3.4 nM						98+%
RS-127445			++++ 5-HT2B, pIC50: 10.4 5-HT2B, pKi: 9.5						99%+
Sarpogrelate HCl			++++ 5-HT2C, Kd: 1.1 nM 5-HT2A, Kd: 2.1 nM						98%
Tropisetron				✔					99%
Ramosetron HCl				++++ 5-HT3 receptor, Ki: 0.091 nM					98%
Ondansetron				✔					99%
Granisetron				✔					98%
Alosetron HCl				✔					98%
Ondansetron HCl dihydrate				✔					98%
VUF10166				++++ 5-HT3A, Ki: 0.04 nM 5-HT3AB, Ki: 22 nM					99%+
Azasetron HCl				++++ 5-HT3, IC50: 0.33 nM					99%
Asenapine maleate		+++ 5-HT1B, pKi: 8.4 5-HT1A, pKi: 8.6	++++ 5-HT2A, pKi: 9.75 5-HT2C, pKi: 10.46		+++ 5-HT5A, pKi: 8.84	++++ 5-HT6, pKi: 9.6	++++ 5-HT7, pKi: 9.94		97%
Risperidone		++ 5-HT1D, Ki: 84.6 nM 5-HT1B, Ki: 14.9 nM	++++ 5-HT2A, Ki: 61.9 nM 5-HT2C, Ki: 12 nM		+ 5-HT5A, Ki: 206 nM		++ 5-HT7, Ki: 6.6 nM		98%
SB 271046 HCl						+++ 5-HT6, pKi: 8.92			99%+
Intepirdine						++++ 5-HT6, pKi: 9.63			99%+
SB-269970 HCl							++ 5-HT7, pKi: 8.3		98+%
BRL 15572		++ 5-HT1D, pKi: 6 5-HT1B, pKi: 6.1	++ 5-HT2A, pKi: 6.6 5-HT2B, pKi: 6.2			+ 5-HT6, pKi: 5.9	+ 5-HT7, pKi: 6.3		95%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Hyperforin/贯叶金丝桃素生物活性

描述	Hyperforin, a pharmacologically active component of the medicinal plant Hypericum perforatum (St. John's wort), has been shown to be neuroprotective against acute ischemic stroke.

Hyperforin/贯叶金丝桃素临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02505191	Healthy	Phase 1	Completed	-	Germany ... 展开 >> Nuvisan GmbH Neu-Ulm, Germany 收起 <<
NCT01726764	Type 2 Diabetes ... 展开 >> Depression 收起 <<	Phase 1	Completed	-	Denmark ... 展开 >> Department of Clinical Pharmacology, Institute of Public Health, University of Southern Denmark Odense, Denmark, DK-5000 收起 <<
NCT01921881	Type 2 Diabetes	Phase 1	Completed	-	Denmark ... 展开 >> Department of Clinical Pharmacology, Institute of Public Health, University of Southern Denmark Odense C, Denmark, DK-5000 收起 <<

Hyperforin/贯叶金丝桃素参考文献

[1]Imreova P, Feruszova J, et al. Hyperforin Exhibits Antigenotoxic Activity on Human and Bacterial Cells. Molecules. 2017 Jan 21;22(1). pii: E167.

[2]Kwon J, Oh KS, et al. Estrogenic Activity of Hyperforin in MCF-7 Human Breast Cancer Cells Transfected with Estrogen Receptor. Planta Med. 2016 Nov;82(16):1425-1430.

Hyperforin/贯叶金丝桃素实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

1.86mL

0.37mL

0.19mL

9.31mL

1.86mL

0.93mL

18.63mL

3.73mL

1.86mL

Hyperforin/贯叶金丝桃素技术信息

CAS号	11079-53-1
分子式	C₃₅H₅₂O₄
分子量	536.79
SMILES Code	O=C1[C@@](C2=O)(CC=C(C)C)C[C@H](CC=C(C)C)[C@](CCC=C(C)C)(C)[C@@]2(C(C(C)C)=O)C(O)=C1CC=C(C)C
MDL No.	MFCD01861497

别名
运输	蓝冰

存储条件	In solvent -20°C: 3-6个月 -80°C: 12个月 Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

Hyperforin/贯叶金丝桃素 {[allProObj[0].p_purity_real_show]}

Hyperforin/贯叶金丝桃素纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

Hyperforin/贯叶金丝桃素质控信息

Hyperforin/贯叶金丝桃素生物活性

Hyperforin/贯叶金丝桃素临床研究

Hyperforin/贯叶金丝桃素参考文献

Hyperforin/贯叶金丝桃素实验方案

Hyperforin/贯叶金丝桃素技术信息

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Hyperforin/贯叶金丝桃素 {[allProObj[0].p_purity_real_show]}

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全球学术期刊中引用的产品

Hyperforin/贯叶金丝桃素 质控信息

Hyperforin/贯叶金丝桃素 生物活性

Hyperforin/贯叶金丝桃素 临床研究

Hyperforin/贯叶金丝桃素 参考文献

Hyperforin/贯叶金丝桃素 实验方案

Hyperforin/贯叶金丝桃素 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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Hyperforin/贯叶金丝桃素纯度/质量文件产品仅供科研

Hyperforin/贯叶金丝桃素质控信息

Hyperforin/贯叶金丝桃素生物活性

Hyperforin/贯叶金丝桃素临床研究

Hyperforin/贯叶金丝桃素参考文献

Hyperforin/贯叶金丝桃素实验方案

Hyperforin/贯叶金丝桃素技术信息