There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
To study the effect of MSC on PI3-K activity, results showed that MSC reduced PI3-K activity by 73% and 84% at 16 and 24 hours, respectively.
Breast Cancer Res. 2005;7(5):R699-707
TM6 mouse mammary epithelial tumor cells
50 µM
16 hours
To study the effect of MSC on DNA synthesis, results showed that MSC inhibited 33% of DNA synthesis at 16 hours.
Breast Cancer Res. 2005;7(5):R699-707
Human neuroblastoma SH-SY5Y cells
1 µM
24 hours
To investigate the effect of MSC on apoptosis in Clu-knockdown SH-SY5Y cells. Results showed that 1 μM MSC could reverse the decrease in antioxidative capacity, Bcl-2/Bax ratio, and increase in caspase-8 activity caused by Clu-knockdown, thereby inhibiting apoptosis and maintaining cell viability.
Int J Mol Sci. 2014 Nov 18;15(11):21331-47
Mouse neuroblastoma N2a cells
1 µM
24 hours
To investigate the effect of MSC on apoptosis in Clu-knockdown N2a cells. Results showed that 1 μM MSC could reverse the decrease in antioxidative capacity, Bcl-2/Bax ratio, and increase in caspase-8 activity caused by Clu-knockdown, thereby inhibiting apoptosis and maintaining cell viability.
Int J Mol Sci. 2014 Nov 18;15(11):21331-47
A549 lung adenocarcinoma cells
50-200 µM
24-48 hours
SeMC inhibited A549 cell growth in a dose-dependent manner
Cell Prolif. 2021 May;54(5):e13038
Primary human hepatocytes
1218 ± 364 µM (IC50)
72 hours
Evaluate the cytotoxicity of MSC on primary human hepatocytes, the IC50 value was 1218 ± 364 µM
Antioxidants (Basel). 2021 Jul 7;10(7):1094
Huh7 cells
1294 ± 336 µM (IC50)
72 hours
Evaluate the cytotoxicity of MSC on HCC cell lines, the IC50 value of Huh7 cells was 1294 ± 336 µM
Antioxidants (Basel). 2021 Jul 7;10(7):1094
Hep3B cells
1875 ± 171 µM (IC50)
72 hours
Evaluate the cytotoxicity of MSC on HCC cell lines, the IC50 value of Hep3B cells was 1875 ± 171 µM
Antioxidants (Basel). 2021 Jul 7;10(7):1094
HEPG2 cells
1152 ± 188 µM (IC50)
72 hours
Evaluate the cytotoxicity of MSC on HCC cell lines, the IC50 value of HEPG2 cells was 1152 ± 188 µM
Antioxidants (Basel). 2021 Jul 7;10(7):1094
Se-Methylselenocysteine HCl/L-硒甲基硒代半胱氨酸 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Nude mice
FaDu and A253 head and neck squamous cell carcinoma xenograft models
Oral
0.2 mg/mouse/day
Daily administration for 7 days (before chemotherapy) and 7 days (after chemotherapy)
Se-methylselenocysteine significantly protected against organ-specific toxicity induced by lethal doses of cyclophosphamide, cisplatin, oxaliplatin, and irinotecan, including diarrhoea, stomatitis, alopecia, bladder, kidney, and bone marrow toxicities. Protection from lethal toxicity by MSC was associated with enhanced antitumour activity in rats bearing advanced Ward colorectal carcinoma and in nude mice bearing human squamous cell carcinoma of the head and neck, FaDu, and A253xenografts.
Antioxidants (Basel). 2019 Jul 5;8(7):207
Fischer 344/N rats
Ward colorectal carcinoma model
Oral
0.25 to 1.25 mg/rat/day
Daily administration for 14 days (before chemotherapy) and 7 days (after chemotherapy)
Se-methylselenocysteine significantly protected against organ-specific toxicity induced by lethal doses of cyclophosphamide, cisplatin, oxaliplatin, and irinotecan, including diarrhoea, stomatitis, alopecia, bladder, kidney, and bone marrow toxicities. Protection from lethal toxicity by MSC was associated with enhanced antitumour activity in rats bearing advanced Ward colorectal carcinoma and in nude mice bearing human squamous cell carcinoma of the head and neck, FaDu, and A253xenografts.
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