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货号 产品名 纯度
A124996 现货 Tenuifolin/细叶远志皂苷

Tenuifolin是从远志中提取的三萜类化合物,具有口服活性和神经保护作用。天茄草皂苷通过抑制 β-分泌酶减少 Aβ 蛋白分泌,抑制 Aβ25-35 诱导的凋亡以及 caspase-3caspase-9 激活。

98%
A943144 现货 LY2886721

LY2886721是一种有效的、选择性的、口服活性的β-位淀粉样前体蛋白裂解酶1(BACE1)抑制剂,对重组人BACE1的IC50为20.3 nM。LY2886721对BACE1具有选择性,但对组织蛋白D、胃蛋白酶和肾素缺乏选择性(IC50为10.2 nM)。LY2886721可穿过血脑屏障,可用于阿尔茨海默病研究。

99%+
A306723 现货 RO4929097

RO4929097(RG-4733)是一种γ分泌酶抑制剂,IC50为4 nM,抑制Aβ40和Notch的细胞加工,EC50分别为14 nM和5 nM。

99%+
A140795 现货 LY-411575

LY-411575是一种高效的 γ-分泌酶抑制剂,其 IC50 值分别为 0.078 nM 和 0.082 nM(膜/细胞基质),并且还以 IC50 为 0.39 nM 抑制 Notch S3 切割。

99%+
A294210 现货 PF-06751979

PF-06751979 is a potent, brain penetrant, β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 7.3 nM in BACE1 binding assay.

99%+
A246701 现货 Verubecestat TFA

99%+
A790356 现货 E 2012

E 2012 is a potent γ-secretase modulator.

98%
A1226355 现货 LY 2886721 HCl

LY 2886721 hydrochloride is the first oral inhibitor of human β-secretase (BACE-1) with the potential to treat Alzheimer's Disease.

98%+
A282700 现货 Sophoflavescenol/槐苦参醇

Sophoflavescenol is a prenylated flavonol, which shows great inhibitory activity with IC50 of 13 nM against phosphodiesterase 5 (PDE5), and also inhibits RLAR, HRAR, AGE, BACE1, AChE and BChE with IC50s of 0.30 μM, 0.17 μM, 17.89 μg/mL, 10.98 μM, 8.37 μM and 8.21 μM, respectively.

98%
A631906 现货 Z-LLNle-CHO

95%
A1549567 现货 PF-06648671

98%+
A1516314 现货 Fosciclopirox

95%
A701939 现货 Eicosapentaenoic acid methyl ester/二十碳五烯酸甲酯

98% GC
A259411 现货 Eslicarbazepine/艾司利卡西平

98%
A1145931 现货 Isorubrofusarin-6-O-β-gentiobioside

99%+
A262054 现货 Verubecestat/维罗司他

Verubecestat is a BACE1 inhibitor. MK-8931 binds significantly to β-secretase.

99%+
A1145654 现货 Compound E

Compound E is an inhibitor of γ-Secretase.

99%+
A886914 现货 AZD3839

AZD3839 is an inhibitor of BACE1 with IC50 of 23.6 uM.

99%+
A604632 现货 Scoulerine

Scoulerine, a natural product isolated and purified from the herbs of Corydalis dubia., shows significant cytotoxic effects against both two cancer cell lines (Caco-2 and Hep-G2 cancer cells), with IC50 values 6.44 ± 0.87 and 4.57 ± 0.42, respectively.

98%
A423338 现货 LY2811376

LY2811376 is the first orally available non-peptidic β-secretase (BACE1) inhibitor with IC50 of 239 nM-249 nM, that acts to decrease Aβ secretion with EC50 of 300 nM, and demonstrates to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin.

99%+
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