WYE-132 | WYE-125132 | mTORC1/mTORC2 Inhibitor | AmBeed-信号通路专用抑制剂

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WYE-132 {[allProObj[0].p_purity_real_show]}

货号：A686362 同义名： WYE-125132

WYE-132是一种高效的、ATP 竞争性特异性 mTOR 激酶抑制剂，IC50 为 0.19 nM，对 mTOR 比对 PI3K 或 PI3K 相关激酶 hSMG1 和 ATR 更具选择性。

WYE-132 化学结构
CAS号：1144068-46-1

WYE-132 3D分子结构
CAS号：1144068-46-1

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WYE-132 纯度/质量文件产品仅供科研

货号：A686362 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]; • Cell, 2025. Ambeed. [ A122167 ]; • Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]; • Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]; • Nat. Nanotechnol., 2025. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]; 更多 >

mTOR 亚型比较

产品名称	mTOR ↓ ↑	mTORC1 ↓ ↑	mTORC2 ↓ ↑	其他靶点	纯度
AZD-8055	++++ mTOR (truncated), IC50: 0.13 nM mTOR (full length), IC50: 0.8 nM				99%+
Gedatolisib	++++ mTOR, IC50: 1.6 nM				99%
GSK1059615	++ mTOR, IC50: 12 nM				98%
Vistusertib	+++ mTOR, IC50: 2.8 nM				99%+
Torin 1	+++ mTOR, IC50: 4.32 nM	+++ mTORC1, IC50: 2 nM	++ mTORC2, IC50: 10 nM	DNA-PK	99%+
Dactolisib	+++ mTOR (p70S6K), IC50: 6 nM				98+%
PI-103	+ mTOR, IC50: 30 nM				99%+
WAY-600	++ mTOR, IC50: 9 nM				99%
Voxtalisib	+ mTOR, IC50: 157 nM				99%+
PF-04691502	++ mTOR, Ki: 16 nM				98+%
Onatasertib	++ mTOR, IC50: 16 nM			DNA-PK	99%+
Chrysophanol	✔			EGFR	98%
Samotolisib	✔			DNA-PK	99%+
Torkinib	+++ mTOR, IC50: 8 nM			PDGFR,DNA-PK	99%+
Everolimus					99%+
WYE-354	+++ mTOR, IC50: 5 nM				98%
Tacrolimus	✔				98%
PP121	++ mTOR, IC50: 13 nM			VEGFR,PDGFR	99%+
Torin 2	++++ mTOR, IC50: 0.25 nM			DNA-PK	99%+
Rapamycin	++++ mTOR, IC50: ~0.1 nM				98%
GDC-0349	+++ mTOR, Ki: 3.8 nM				98%
XL388	++ mTOR, IC50: 9.9 nM	+++ mTORC1, IC50: 8 nM	+ mTORC2, IC50: 166 nM		99%+
WYE-687	+++ mTOR, IC50: 7 nM				98%
Apitolisib	+ mTOR, Ki app: 17 nM				98%+
WYE-132	++++ mTOR, IC50: 0.19 nM				99%+
Sapanisertib	++++ mTOR, Ki: 1.4 nM				99%+
BGT226 maleate	✔				99%+
ETP-46464	++++ mTOR, IC50: 0.6 nM			DNA-PK	98%
PI3K-IN-1	+ mTOR, IC50: 157 nM				98+%
Zotarolimus	+++ FKBP-12, IC50: 2.8 nM				98%
OSI-027	+++ mTOR, IC50: 4 nM	+ mTORC1, IC50: 22 nM	+ mTORC2, IC50: 65 nM		99%+
Ridaforolimus	++++ mTOR, IC50: 0.2 nM				99%+
Temsirolimus	+ mTOR, IC50: 1.76 μM				95%
CZ415	++ mTOR, pIC50: 8.07				99%+
SF2523	+ mTOR, IC50: 280 nM			DNA-PK	99%+
KU-0063794		++ mTORC1, IC50: ~10 nM	++ mTORC2, IC50: ~10 nM		99%+
Omipalisib		++++ mTORC1, Ki: 0.18 nM	++++ mTORC2, Ki: 0.3 nM		99%+
Palomid 529		✔			99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

WYE-132 生物活性

靶点	mTOR mTOR, IC50:0.19 nM
描述	WYE-125132 is a highly potent, ATP-competitive and specific mTOR kinase inhibitor with an IC50 of 0.19 nM, highly selective for mTOR versus PI3Ks or PI3K-related kinases hSMG1 and ATR.

WYE-132 细胞实验

Cell Line Human foreskin fibroblast cells (HFF) African green monkey kidney cells (Vero) HEK293 MG63	Concentration	Treated Time	Description	References
Human foreskin fibroblast cells (HFF)	5 µM	20 hours	WYE-132 significantly inhibited parasite growth and caused abnormal localization of TgGST2	Parasit Vectors. 2022 Dec 12;15(1):461.
African green monkey kidney cells (Vero)	5 µM	20 hours	WYE-132 significantly inhibited parasite growth and caused abnormal localization of TgGST2	Parasit Vectors. 2022 Dec 12;15(1):461.
HEK293	0.5 µM	3 hours	Measure the level of tRNA precursors, WYE-132 significantly reduced pre-tRNA levels	J Biol Chem. 2010 May 14;285(20):15380-15392.
MG63	0.5 µM	3 hours	Measure the level of tRNA precursors, WYE-132 significantly reduced pre-tRNA levels	J Biol Chem. 2010 May 14;285(20):15380-15392.

WYE-132 动物实验

Species Arabidopsis thaliana Drosophila melanogaster	Animal Model A. thaliana WT and TOR/tor-1 heterozygotes Y w male Drosophila	Administration	Dosage	Frequency	Description	References
Arabidopsis thaliana	A. thaliana WT and TOR/tor-1 heterozygotes	Solid medium	0.01-1 μM	Single administration, lasting 6 days	WYE-132 inhibited Arabidopsis root growth, and TOR/tor-1 heterozygotes were twice as sensitive to WYE-132 as WT.	J Exp Bot. 2013 Nov;64(14):4361-74
Drosophila melanogaster	Y w male Drosophila	Dietary supplementation	10 pM to 1 µM	Lifelong supplementation	Testing the effect of WYE-132 on lifespan; a slight increase (5-6%) at the lowest dose (10 pM), but no significant effect at other doses	Int J Mol Sci. 2024 Oct 26;25(21):11504

WYE-132 参考文献

[1]Yu K, Shi C, et al. Beyond rapalog therapy: preclinical pharmacology and antitumor activity of WYE-125132, an ATP-competitive and specific inhibitor of mTORC1 and mTORC2. Cancer Res. 2010 Jan 15;70(2):621-31.

[2]Shor B, Wu J, et al. Requirement of the mTOR kinase for the regulation of Maf1 phosphorylation and control of RNA polymerase III-dependent transcription in cancer cells. J Biol Chem. 2010 May 14;285(20):15380-92.

WYE-132 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

1.92mL

0.38mL

0.19mL

9.62mL

1.92mL

0.96mL

19.25mL

3.85mL

1.92mL

WYE-132 技术信息

CAS号	1144068-46-1
分子式	C₂₇H₃₃N₇O₄
分子量	519.6
SMILES Code	O=C(NC)NC1=CC=C(C2=NC(N3CC(O4)CCC4C3)=C5C(N(C(CC6)CCC76OCCO7)N=C5)=N2)C=C1
MDL No.	MFCD22420813

别名	WYE-125132
运输	蓝冰

存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Sealed in dry, store in freezer, under -20°C

溶解方案

细胞实验：

DMSO: 25 mg/mL(48.11 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验：请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用；以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

WYE-132 {[allProObj[0].p_purity_real_show]}

WYE-132 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

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WYE-132 生物活性

WYE-132 细胞实验

WYE-132 动物实验

WYE-132 参考文献

WYE-132 实验方案

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WYE-132 {[allProObj[0].p_purity_real_show]}

WYE-132 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

WYE-132 质控信息

WYE-132 生物活性

WYE-132 细胞实验

WYE-132 动物实验

WYE-132 参考文献

WYE-132 实验方案

WYE-132 技术信息

最近浏览的产品

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WYE-132 纯度/质量文件产品仅供科研