Osthole, a natural coumarin found in traditional Chinese medicinal herbs, has therapeutic potential in the treatment of various diseases. Mice were administered osthole (100 mg/kg/d, ip) for 3 d, then on the fourth day APAP (Acetaminophen) (300 mg/kg, ip) was co-administered with osthole. Compared with the mice treated with APAP alone, osthole pretreatment significantly reduced serum MDA levels and hepatic H2O2 levels, and improved liver GSH levels and the GSSG-to-GSH ratio. In cultured murine primary hepatocytes and Raw264.7 cells, however, osthole (40 μM) did not alleviate APAP-induced cell death, but it significantly suppressed APAP-caused elevation of inflammatory cytokines[3]. Mice were injected with osthole (100 mg/kg, ip) or vehicle, followed by TMX (Tamoxifen, 90 mg/kg, ip) 24 h later. Osthole prevents TMX hepatotoxicity by suppressing p38 activation and subsequently reducing TMX-induced oxidative damage[4]. Pretreatment with osthole (100 mg/kg/d, ip, 3d) significantly ameliorated the clinical scores, colon length shortening, colonic histopathological changes and the expression of inflammatory mediators in TNBS-induced colitis. In mouse peritoneal macrophages, pretreatment with osthole (50 μM) significantly attenuated the LPS-induced elevation of cytokines at the mRNA level[5]. Osthole can be considered as a potential component of the treatment of Osteoarthritis, for it possesses a cartilage protective effect, as well as anti-inflammation, analgesic, and movement improving effects[6].
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