Anacardic acid is a potent inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases, which also has antibacterial activity, antimicrobial activity,prostaglandin synthase inhibition, and tyrosinase and lipoxygenase inhibition.
Anacardic Acid/漆树酸 细胞实验
Cell Line
Concentration
Treated Time
Description
References
LNCaP cells
0, 5, 25, 125 µM
0, 4, 24, 48 hours
To investigate the effects of AA on LNCaP cell proliferation, it was found that AA significantly inhibited LNCaP cell proliferation, with the optimal concentration being 125 μmol/L and the optimal exposure time being 24 hours.
Chin J Cancer Res. 2012 Dec;24(4):275-83.
A375
0.2 to 50 µM
48 and 72 hours
To evaluate the cytotoxicity of Anacardic Acid on melanoma cell lines, results showed that Anacardic Acid significantly enhanced the cytotoxicity of liposomal Mitoxantrone.
Int J Nanomedicine. 2014 Jan 23;9:653-68.
Hs294T
0.2 to 50 µM
48 and 72 hours
To evaluate the cytotoxicity of Anacardic Acid on melanoma cell lines, results showed that Anacardic Acid significantly enhanced the cytotoxicity of liposomal Mitoxantrone.
Int J Nanomedicine. 2014 Jan 23;9:653-68.
NHDF
0.2 to 50 µM
48 and 72 hours
To evaluate the cytotoxicity of Anacardic Acid on normal cells, results showed that vitamin C had a protective effect on normal cells.
Int J Nanomedicine. 2014 Jan 23;9:653-68.
MCF-7
1 nM – 100 µM
48 hours
To evaluate the inhibitory effect of AnAc 24:1ω5 on the proliferation of MCF-7 cells
Mol Cancer Ther. 2010 Mar;9(3):594-605.
LCC9
1 nM – 100 µM
48 hours
To evaluate the inhibitory effect of AnAc 24:1ω5 on the proliferation of LCC9 cells
Mol Cancer Ther. 2010 Mar;9(3):594-605.
LY2
1 nM – 100 µM
48 hours
To evaluate the inhibitory effect of AnAc 24:1ω5 on the proliferation of LY2 cells
Mol Cancer Ther. 2010 Mar;9(3):594-605.
MCF-10A
1 nM – 100 µM
48 hours
To evaluate the inhibitory effect of AnAc 24:1ω5 on the proliferation of MCF-10A cells
Mol Cancer Ther. 2010 Mar;9(3):594-605.
MDA-MB-231
1 nM – 100 µM
48 hours
To evaluate the inhibitory effect of AnAc 24:1ω5 on the proliferation of MDA-MB-231 cells
Mol Cancer Ther. 2010 Mar;9(3):594-605.
Vero-E6 cells
15 µM
48 hours
To evaluate the antiviral potency of Anacardic Acid against SARS-CoV-2 in vitro, the results showed significant reduction in virus plaque formation at non-toxic concentrations.
Cell Biosci. 2021 Feb 28;11(1):45.
Rat oligodendrocyte precursor cells (OPCs)
10 µM
Anacardic acid induced the expression of myelin basic protein (MBP) and increased the expression of genes involved in the transcription of myelin proteins.
Proc Natl Acad Sci U S A. 2020 Sep 1;117(35):21527-21535.
Rat oligodendrocyte precursor cells (OPCs)
5.0 µM
Anacardic acid increased the mRNA expression of Mbp, Sp1, Sox10, and Purα.
Proc Natl Acad Sci U S A. 2020 Sep 1;117(35):21527-21535.
Rat oligodendrocyte precursor cells (OPCs)
2.5 µM
Anacardic acid increased the mRNA expression of IL-33.
Proc Natl Acad Sci U S A. 2020 Sep 1;117(35):21527-21535.
Anacardic Acid/漆树酸 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
C57/B6 mice
Experimental allergic encephalitis (EAE) and cuprizone-induced demyelination model
0.025 mg/kg to 2.5 mg/kg
Daily administration for 9 weeks
Anacardic acid improved pathological scores in EAE and cuprizone models and promoted remyelination.
Proc Natl Acad Sci U S A. 2020 Sep 1;117(35):21527-21535.
Cytotoxicity against human HCT116 cells after 72 hrs by luciferase reporter gene assay, IC50=0.38 μM
23245311
Hi5 cells
Function assay
Non-competitive inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells
23245311
Hi5 cells
Function assay
Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells assessed as ADP formation incubated for 20 mins proir to substrate addition measured after 90 mins by NADH coupled assay, IC50=0.024 μM
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