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DMAT {[allProObj[0].p_purity_real_show]}

货号：A767723 同义名： Casein kinase II Inhibitor; CK2 Inhibitor

DMAT是一种特异性的酪蛋白激酶 (CK2) 抑制剂，IC50约为130 nM，用于研究各种酪蛋白激酶相关病理过程。

DMAT 化学结构 CAS号：749234-11-5
DMAT 化学结构
CAS号：749234-11-5
DMAT 3D分子结构
CAS号：749234-11-5
DMAT 化学结构 CAS号：749234-11-5
DMAT 3D分子结构 CAS号：749234-11-5
规格 价格 会员价 库存 数量
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DMAT 纯度/质量文件 产品仅供科研

货号：A767723 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]
• Cell, 2025. Ambeed. [ A122167 ]
• Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]
• Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]
• Nat. Nanotechnol., 2025. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]
更多 >
产品名称 CK1 ↓ CK2 ↓ 其他靶点 纯度
PF-670462 2HCl ++++

CK1ε, IC50: 90 nM

CK1δ, IC50: 13 nM

 		99%+
D4476 ++

CK1 from Schizosaccharomyces pombe, IC50: 200 nM

CK1δ, IC50: 300 nM

 		99%
SR-3029 +++

CK1ε, IC50: 260 nM

CK1δ, IC50: 44 nM

 		99%+
IWP-2 +++

M82FCK1δ, IC50: 40 nM

 		Wnt 99%
LY364947 ++

CK1δ, IC50: 0.22 μM

 		98%
TA-01 ++++

CK1ε, IC50: 6.4 nM

CK1δ, IC50: 6.8 nM

 		p38 MAPK 99%+
IC261 +

CK1, IC50: 16 μM

 		98%
PF-4800567 +++

casein kinase 1 delta, IC50: 711 nM

casein kinase 1 epsilon, IC50: 32 nM

 		99%+
CK1-IN-1 ++++

CK1ε, IC50: 16 nM

CK1δ, IC50: 15 nM

 		99%
Longdaysin +

CKIδ, IC50: 8.8 μM

CKIα, IC50: 5.6 μM

 		99%+
Silmitasertib ++++

CK2, IC50: 1 nM

 		99%+
Ellagic acid (hydrate) +++

CK2, IC50: 0.04 μM

 		PKA 95+%
DMAT +++

CK2, Ki: ~40 nM

 		99%
Hematein ++

CK2, IC50: 0.55 μM

 		40%
Silmitasertib sodium salt ++++

CK2α', IC50: 1 nM

CK2α, IC50: 1 nM

 		99%+
LY294002 +++

CK2, IC50: 98 nM

 		99%+
A-3 HCl +

CK1, Ki: 80 μM

 		++

CK2, Ki: 5.1 μM

 		PKC,MLCK,PKA 98+%
TBB +

CK1, Ki: 47 μM

 		++

CK2, Ki: 0.4 μM

 		98%
TTP 22 ++

CK2, IC50: 100 nM

 		98%+
DRB ✔ 99%+
BioE-1115 +

CK2α, IC50: 10 μM

 		99%+
(E/Z)-GO289 ++++

CK2, IC50: 7 nM

 		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

DMAT 生物活性

靶点

  • CK2

    CK2, Ki:~40 nM
描述 DMAT is a potent and specific CK2 inhibitor with an IC50 value of 130 nM.

DMAT 细胞实验

Cell Line
Concentration Treated Time Description References
GBC 10 µM 72 hours DMAT significantly reduces cell viability and induces apoptosis Int J Biol Sci. 2012;8(1):15-29.
SkChA-1 10 µM 72 hours DMAT significantly reduces cell viability and induces apoptosis Int J Biol Sci. 2012;8(1):15-29.
MzChA-2 10 µM 72 hours DMAT significantly reduces cell viability and induces apoptosis Int J Biol Sci. 2012;8(1):15-29.
MzChA-1 10 µM 72 hours DMAT significantly reduces cell viability and induces apoptosis Int J Biol Sci. 2012;8(1):15-29.
CCSW-1 10 µM 72 hours DMAT significantly reduces cell viability and induces apoptosis Int J Biol Sci. 2012;8(1):15-29.
Human brain microvascular endothelial cells (HBMVEC) 50-100 μM 8 hours DMAT induced dramatic changes in cell shape, including cell retraction and rounding, which were reversible within 8 hours. Mol Cell Biochem. 2011 Mar;349(1-2):125-37.
Human astrocytes (HAST-40) 50-100 μM 6 hours DMAT induced dramatic changes in cell shape, including cell retraction and rounding, which were reversible within 6 hours. Mol Cell Biochem. 2011 Mar;349(1-2):125-37.
TFK 10 µM 72 hours DMAT significantly reduces cell viability and induces apoptosis Int J Biol Sci. 2012;8(1):15-29.
EGI-1 10 µM 72 hours DMAT significantly reduces cell viability and induces apoptosis Int J Biol Sci. 2012;8(1):15-29.
3T3-L1 cells 30 µM Inhibited adipogenesis in 3T3-L1 cells Molecules. 2021 Aug 5;26(16):4747.
BDC 10 µM 72 hours DMAT significantly reduces cell viability and induces apoptosis Int J Biol Sci. 2012;8(1):15-29.
CCLP-1 10 µM 72 hours DMAT significantly reduces cell viability, induces apoptosis, and inhibits Wnt signaling pathway Int J Biol Sci. 2012;8(1):15-29.
UM-SCC-46 10, 20 μM 48 hours Inhibited mRNA expression of CSC marker genes Nanog, Oct4, and Sox2 Neoplasia. 2014 Oct 23;16(10):789-800.
UM-SCC-22A 10, 20 μM 48 hours Inhibited mRNA expression of CSC marker genes Nanog, Oct4, and Sox2 Neoplasia. 2014 Oct 23;16(10):789-800.
H1299 cells 2.5 or 12.5 µM 20 hours Inhibition of CK2 activity, reduction of E1B-55K phosphorylation J Virol. 2012 Mar;86(5):2400-15.
A549 cells 2.5 or 12.5 µM 20 hours Inhibition of CK2 activity, reduction of E1B-55K phosphorylation J Virol. 2012 Mar;86(5):2400-15.
HMDM cells 1μM 15h DMAT significantly stimulated HMDM cells to kill VRE bacteria ACS Infect Dis. 2024 May 10;10(5):1725-1738.
RAW264.7 cells 1μM 15h DMAT significantly stimulated RAW264.7 cells to kill VRE bacteria ACS Infect Dis. 2024 May 10;10(5):1725-1738.

DMAT 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
Mice Wound infection model IP injection 5mg/kg Single dose DMAT significantly reduced VRE bacterial load in wounds ACS Infect Dis. 2024 May 10;10(5):1725-1738.

DMAT 参考文献

[1]Lawnicka H, Kowalewicz-Kulbat M, et al. Anti-neoplastic effect of protein kinase CK2 inhibitor, 2-dimethylamino-4,5,6,7-tetrabromobenzimidazole (DMAT), on growth and hormonal activity of human adrenocortical carcinoma cell line (H295R) in vitro. Cell Tissue Res. 2010 May;340(2):371-9.

[2]Yde CW, Frogne T, et al. Induction of cell death in antiestrogen resistant human breast cancer cells by the protein kinase CK2 inhibitor DMAT. Cancer Lett. 2007 Oct 28;256(2):229-37.

DMAT 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.10mL

0.42mL

0.21mL

10.49mL

2.10mL

1.05mL

20.97mL

4.19mL

2.10mL

DMAT 技术信息

CAS号749234-11-5
分子式C9H7Br4N3
分子量 476.79
SMILES Code CN(C)C1=NC2=C(Br)C(Br)=C(Br)C(Br)=C2N1
MDL No. MFCD08705322
别名 Casein kinase II Inhibitor; CK2 Inhibitor; 2-Dimethylamino-4,5,6,7-tetrabromobenzimidazole; Casein Kinase II Inhibitor II
运输蓝冰
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Sealed in dry, store in freezer, under -20°C
溶解方案

DMSO: 50 mg/mL(104.87 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一

Tags: DMAT | 749234-11-5 | CK2 Inhibitor | Casein kinase II Inhibitor | Casein Kinase Inhibitor | Cell Cycle/DNA Damage | Stem Cell/Wnt | Casein Kinase | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | DMAT 纯度/质量文件 | DMAT 亚型比较 | DMAT 生物活性 | DMAT 参考文献 | DMAT 实验方案 | DMAT 技术信息

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