DMAT

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Chemical Structure| 749234-11-5 同义名 : Casein kinase II Inhibitor; CK2 Inhibitor; 2-Dimethylamino-4,5,6,7-tetrabromobenzimidazole; Casein Kinase II Inhibitor II
CAS号 : 749234-11-5
货号 : A767723
分子式 : C9H7Br4N3
纯度 : 99%
分子量 : 476.79
MDL号 : MFCD08705322
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(104.87 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • CK2

    CK2, Ki:~40 nM
描述 DMAT is a potent and specific CK2 inhibitor with an IC50 value of 130 nM.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.10mL

0.42mL

0.21mL

10.49mL

2.10mL

1.05mL

20.97mL

4.19mL

2.10mL
参考文献

[1]Lawnicka H, Kowalewicz-Kulbat M, et al. Anti-neoplastic effect of protein kinase CK2 inhibitor, 2-dimethylamino-4,5,6,7-tetrabromobenzimidazole (DMAT), on growth and hormonal activity of human adrenocortical carcinoma cell line (H295R) in vitro. Cell Tissue Res. 2010 May;340(2):371-9.

[2]Yde CW, Frogne T, et al. Induction of cell death in antiestrogen resistant human breast cancer cells by the protein kinase CK2 inhibitor DMAT. Cancer Lett. 2007 Oct 28;256(2):229-37.