TBB
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货号：A133565
TBB是一种高度选择性的ATP/GTP竞争性Casein kinase-2（CK2）抑制剂，对于大鼠肝脏和人类重组CK2的IC50分别为0.9和1.6 μM。
TBB 3D分子结构
规格
价格
会员价
库存
数量
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现货
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TBB 纯度/质量文件 产品仅供科研
货号：A133565
标准纯度：
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产品说明书
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TBB 质控信息
PF-670462 2HCl
++++
CK1ε, IC50: 90 nM
CK1δ, IC50: 13 nM
99%+
D4476
++
CK1 from Schizosaccharomyces pombe, IC50: 200 nM
CK1δ, IC50: 300 nM
99%
SR-3029
+++
CK1ε, IC50: 260 nM
CK1δ, IC50: 44 nM
99%+
IWP-2
+++
Wnt
99%
LY364947
++
98%
TA-01
++++
CK1ε, IC50: 6.4 nM
CK1δ, IC50: 6.8 nM
p38 MAPK
99%+
IC261
+
98%
PF-4800567
+++
casein kinase 1 delta, IC50: 711 nM
casein kinase 1 epsilon, IC50: 32 nM
99%+
CK1-IN-1
++++
CK1ε, IC50: 16 nM
CK1δ, IC50: 15 nM
99%
Longdaysin
+
CKIδ, IC50: 8.8 μM
CKIα, IC50: 5.6 μM
99%+
Silmitasertib
++++
99%+
Ellagic acid (hydrate)
+++
PKA
95+%
DMAT
+++
99%
Hematein
++
40%
Silmitasertib sodium salt
++++
CK2α', IC50: 1 nM
CK2α, IC50: 1 nM
99%+
LY294002
+++
99%+
A-3 HCl
+
++
PKC,MLCK,PKA
98+%
TBB
+
++
98%
TTP 22
++
98%+
DRB
✔
99%+
BioE-1115
+
99%+
(E/Z)-GO289
++++
99%+
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
TBB 生物活性
靶点
CK2
CK2, Ki:0.4 μM
CK1
CK1, Ki:47 μM
描述
The inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) is a selective inhibitor for the protein kinase CK2 (IC50 1.6 micro m)[3] [4] [5]
TBB 细胞实验
Cell Line
Concentration
Treated Time
Description
References
Jurkat cells
30 µM
15 hours
TBB induces apoptosis in Jurkat cells, leading to PARP protein degradation, cytochrome c release, and DNA fragmentation.
Biochem J. 2002 May 15;364(Pt 1):41-7.
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TBB 参考文献
[1] Orzechowska E, Kozlowska E, et al. Time schedule-dependent effect of the CK2 inhibitor TBB on PC-3 human prostate cancer cell viability. Oncol Rep. 2012 Jan;27(1):281-5.
[2] De Moliner E, Brown NR, Johnson LN. Alternative binding modes of an inhibitor to two different kinases. Eur J Biochem. 2003 Aug;270(15):3174-81.
[3] De Moliner E, Brown NR, Johnson LN. Alternative binding modes of an inhibitor to two different kinases. Eur J Biochem. 2003 Aug;270(15):3174-81
[4] Sarno S, Reddy H, Meggio F, Ruzzene M, Davies SP, Donella-Deana A, Shugar D, Pinna LA. Selectivity of 4,5,6,7-tetrabromobenzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ('casein kinase-2'). FEBS Lett. 2001 May 4;496(1):44-8
[5] Orzechowska E, Kozłowska E, Staroń K, Trzcińska-Danielewicz J. Time schedule-dependent effect of the CK2 inhibitor TBB on PC-3 human prostate cancer cell viability. Oncol Rep. 2012 Jan;27(1):281-5
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TBB 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.30mL
0.46mL
0.23mL
11.50mL
2.30mL
1.15mL
23.00mL
4.60mL
2.30mL
TBB 技术信息
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