CAY10602 is a SIRT1 activator that dose-dependently inhibits the NF-κB-dependent induction of TNF-α by LPS in THP-1 cells at concentrations ranging from 20 to 60 μM. CAY10602 has a significant effect on fat mobilisation in differentiated adipocytes and possesses anti-obesity and/or antidiabetic properties[1].
CAY10602 细胞实验
Cell Line
Concentration
Treated Time
Description
References
HT22 neuronal cells
10 μM
24 h
To evaluate the effect of CAY10602 on ammonia-induced neurotoxicity, results showed that CAY10602 reduced ammonia-induced apoptosis and ROS levels in HT22 cells.
Oxid Med Cell Longev. 2021 Oct 12;2021:5522708
BV2 microglial cells
10 μM
To evaluate the effect of CAY10602 on NLRP3 inflammasome activation, results showed that CAY10602 inhibited LPS and ATP-induced NLRP3 inflammasome activation.
Oxid Med Cell Longev. 2021 Oct 12;2021:5522708
BV2 microglial cells
1, 4, 8, 10 μM
8 h
To evaluate the activation effect of CAY10602 on SIRT1, results showed that CAY10602 upregulated the protein expression of SIRT1 in a dose-dependent manner.
Oxid Med Cell Longev. 2021 Oct 12;2021:5522708
vascular smooth muscle cells (VSMCs)
10 µmol·L−1
24 h
To verify the effect of SIRT1 activator CAY10602 on PA-induced mitochondrial dysfunction, the results showed that CAY10602 could further promote the effect of Deh on SIRT1 expression and inhibit Drp1 expression and mitochondrial dysfunction.
Lipids Health Dis. 2025 May 24;24(1):187
HepG2 cells
20 μM
2 h
CAY10602, as a SIRT-1 activator, reversed the OA-induced decrease in HepG2 cell viability, reduced apoptosis and lipid accumulation, and alleviated ROS production.
Lipids Health Dis. 2021 Apr 26;20(1):40
CAY10602 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Wistar rats
Thioacetamide (TAA)-induced hepatic encephalopathy model
Intraperitoneal injection
5 mg/kg
Once daily for 3 days
To evaluate the therapeutic effect of CAY10602 on hepatic encephalopathy, results showed that CAY10602 alleviated liver injury, improved neurological decline, reduced microglial activation and brain oxidative stress, and improved the survival rates of HE rats.
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