AZD3514是一种强效的口服雄激素受体下调剂，Ki 为 2.2 μM，具有减少 AR 蛋白表达的能力。
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Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
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Accessible (Haz class 3, 4, 5 or 8), Domestic
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Accessible (Haz class 3, 4, 5 or 8), International
AZD3514 is a potent and oral androgen receptor downregulator with Ki of 2.2 μM and has ability of reducing AR protein expression.
AZD3514 细胞实验
Cell Line
Concentration
Treated Time
Description
References
LAPC4 cells
10 µM
To evaluate the inhibitory effect of AZD3514 on DHT-driven proliferation of LAPC4 cells, results showed 10 µM AZD3514 inhibited cell proliferation
Mol Cancer Ther. 2013 Sep;12(9):1715-27
LNCaP cells
10 µM
7 days
To evaluate the inhibitory effect of AZD3514 on DHT-driven proliferation of LNCaP cells, results showed AZD3514 inhibited cell proliferation in a dose-dependent manner
Mol Cancer Ther. 2013 Sep;12(9):1715-27
AZD3514 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Male Hans Wistar rats
Intact rat model
Oral gavage
50 mg/kg
Once daily for 6 days
To evaluate the inhibitory effect of AZD3514 on seminal vesicle development in intact male rats, results showed AZD3514 significantly reduced seminal vesicle weight
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