There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
The androgen receptor (AR) and the androgen-AR signaling pathway play a significant role in male sexual differentiation and the development and function of male reproductive and non-reproductive organs [7]. ARN-509 is a competitive AR inhibitor (IC50=16 nM) which is fully antagonistic to AR overexpression, a common and important feature of castration-resistant prostate cancer (CRPC). In castration-resistant LNCaP/AR cells, ARN-509 (< 10 μM; 3d) antagonized androgen-mediated induction or repression of mRNA expression-levels for 13 endogenous genes including PSA and TMPRSS2, and ARN-509 (< 10 μM) also antagonized the proliferative effect of R1881 (30pM). Following 17 days of treatment with ARN-509 (10 mg/kg/day) in a model of castration-resistant prostate cancer, androgen-driven luciferase reporter-gene activity was consistently reduced compared to vehicle, indicating AR inhibition by ARN-509 in vivo. In castrate mice bearing LNCaP/AR (cs) xenograft tumors, 8/10 ARN-509-treated (10 mg/kg/day) tumors regressed by >50% (volume) on day 28 [8].
Apalutamide 细胞实验
Cell Line
Concentration
Treated Time
Description
References
Calu-3 cells
10, 25 µM
48 hours
To evaluate the effect of Apalutamide on SARS-CoV-2 infection, results showed that Apalutamide significantly reduced SARS-CoV-2 infection in Calu-3 cells.
Int J Mol Sci. 2023 Feb 7;24(4):3288.
Calu-3 cells
1, 5, 10, 25 µM
72 hours
To evaluate the effect of Apalutamide on TMPRSS2 protein levels, results showed a non-significant modulation of TMPRSS2 protein levels after apalutamide treatment.
Int J Mol Sci. 2023 Feb 7;24(4):3288.
LNCaP
45.48 µM
8 weeks
Establish apalutamide-resistant prostate cancer cell lines and confirm that apalutamide activates the release of calcium ions and endoplasmic reticulum stress to enhance autophagy.
J Transl Med. 2024 Jun 6;22(1):538.
C4-2
20.16 µM
8 weeks
Establish apalutamide-resistant prostate cancer cell lines and confirm that apalutamide activates the release of calcium ions and endoplasmic reticulum stress to enhance autophagy.
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